Unlock instant, AI-driven research and patent intelligence for your innovation.

Cefradine lipidosome for injection and preparation method thereof

A technology for cephradine and injection, which is applied in the field of cephradine liposome for injection and its preparation, can solve the problems of low stability of cephradine, high drug toxicity and side effects, and poor patient compliance, and achieve convenient transportation and storage, small side effects, The effect of improving compliance

Inactive Publication Date: 2012-04-04
傅苗青
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the low stability of cephradine and the high side effects of the drug, especially the pain of intravenous injection, the patient's compliance is poor, which affects the therapeutic effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cefradine lipidosome for injection and preparation method thereof
  • Cefradine lipidosome for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Cephradine liposome for injection, comprises following raw material and content in every 1000 bottles of cephradine liposome for injection:

[0027] Cephradine (sterile) 500g;

[0028] Sodium carbonate 20g;

[0029] Soy lecithin 1500g;

[0030] Cholesterol 500g;

[0031] Vitamin E 20g;

[0032] DSPE-PEG 125g.

[0033] The method for preparing above-mentioned cephradine liposome for injection comprises the following steps:

[0034] (1) Dissolve soybean lecithin, cholesterol, vitamin E, and DSPE-PEG in chloroform organic solvent according to the above ratio, heat and stir to disperse evenly, remove the organic solvent under reduced pressure on a rotary thin film evaporator to obtain a phospholipid film, and then Add an appropriate amount of citric acid-buffer solution with a pH value of 5.6 and stir to dissolve to obtain a blank liposome solution;

[0035] (2) Dissolve the prescribed amount of cephradine (sterile) and sodium carbonate in 3000ml of water for injectio...

Embodiment 2

[0038] Cephradine liposome for injection, comprises following raw material and content in every 1000 bottles of cephradine liposome for injection:

[0039] Cephradine (sterile) 1000g;

[0040] Sodium carbonate 40g;

[0041] Soy lecithin 3000g;

[0042] Cholesterol 1000g;

[0043] Vitamin E 40g;

[0044] DSPE-PEG 250g.

[0045] The method for preparing above-mentioned cephradine liposome for injection comprises the following steps:

[0046] (1) Dissolve soybean lecithin, cholesterol, vitamin E, and DSPE-PEG in chloroform organic solvent according to the above ratio, heat and stir to disperse evenly, remove the organic solvent under reduced pressure on a rotary thin film evaporator to obtain a phospholipid film, and then Add an appropriate amount of citric acid-buffer solution with a pH value of 5.6 and stir to dissolve to obtain a blank liposome solution;

[0047] (2) Dissolve the prescribed amount of cephradine (sterile) and sodium carbonate in 6000ml of water for inject...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of medical technology and discloses cefradine lipidosome for injection and a preparation method thereof. The cefradine lipidosome comprises the following raw materials in parts by weight: 1 part of cefradine lipidosome (aseptic), 0.03-0.1 part of sodium carbonate, 3-5 parts of soybean lecithin, 0.8-2 parts of cholesterol, 0.03-0.1 part of vitamin E and 0.2-0.3 part of DSPE-PEG (Dipalmitoylphosphatidylethanolamine-Polyethylene Glycol). The product has the advantages of high stability, small side effect, effective reduction in the toxic and side effects of a medicament, reduction in the dosage of the medicament, relieving in the injection pain and contribution to enhancing the treatment compliance of a patient. Cracking caused by dehydration, fusion, crystal generation and the like does not occur in the freeze drying process, high envelop rate can be kept after water freezing, and convenience is brought to product transportation and storage.

Description

Technical field [0001] The present invention involves the field of pharmaceutical technology, and especially involves a cephalia lipid body and their preparation methods for injection. Background technique [0002] The main ingredient of cephalosporin in injection is cephalosporin, and its chemical name is (6R, 7R) -7 [(R) -2-amino-2- (1,4-cyclonelcene) acetyl amino group] -3-methyl-8-Oxygen-5-sulfur miscellaneous-1-nitrogen miscellaneous two-ring (4.2.0) Xin-2-olene-2-carboxylic acid, molecular type C 16 H 19 N 3 O 4 S, molecular weight is 349.40; this product is the first generation of cephalosporin, non -producing penicillin enzymes and penicillininase methacinobacteria, coagulanticase -negative bacteria, hemolytic links in group A, pneumonia, and straw green splin bacteria, etc.Some strains of Lan -positive bacteria have good antibacterial effects.The anaerobic Gram -positive bacteria are more sensitive to this product, and the fragile bacteria are resistant to this product.P...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/127A61K31/545A61P31/04
Inventor 傅苗青傅妙英
Owner 傅苗青