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Negative pressure treatment wound surface patch containing metal ion antibacterial agent and preparation method for patch

A metal ion, negative pressure treatment technology, applied in the field of medical supplies, can solve the problems of lack of wound covering materials, refractory wound effect, poor self-healing ability, etc. Effect

Inactive Publication Date: 2012-05-02
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The deficiency that exists at present mainly is: the negative pressure therapy dressing that uses only contains medical sponge and drainage tube, lacks good wound covering material, thereby can only utilize the mechanical attraction effect of negative pressure on the treatment mechanism, and effect is comparatively single; Complicated, difficult-to-heal wounds with infection and poor self-healing ability have limited effect

Method used

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  • Negative pressure treatment wound surface patch containing metal ion antibacterial agent and preparation method for patch
  • Negative pressure treatment wound surface patch containing metal ion antibacterial agent and preparation method for patch

Examples

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Effect test

Embodiment 1

[0036] Hydrophobic zinc-containing chitosan non-woven fabric, using chitosan non-woven fabric with medium molecular weight (60000) and deacetylation degree of 50% as raw material, adopts propylene polymerization (polymerization rate 300%) to carry out the adsorption of zinc ions, so that The zinc adsorption amount reaches 150mg / g; the hydrophobic zinc-containing chitosan nonwoven fabric is composed of 5 layers, and its thickness is about 3mm, which ensures that the zinc release amount remains at 1.7μmol / cm when in use 2 ; The hydrophilic polyurethane is used to absorb the wound exudate absorbed by the chitosan non-woven fabric, the thickness of which is 12mm, and the porosity is 50%.

Embodiment 2

[0038] Hydrophobic zinc-containing chitosan non-woven fabric, using chitosan non-woven fabric with medium molecular weight (45000) and deacetylation degree of 60% as raw material, adopts propylene polymerization (polymerization rate 200%) to carry out the adsorption of zinc ions, so that The zinc adsorption capacity reaches 100mg / g; the hydrophobic zinc-containing chitosan non-woven fabric is composed of 10 layers, and its thickness is about 7mm, which ensures that the zinc release rate remains at 1.2μmol / cm when in use 2 ; The hydrophilic polyurethane is used to absorb the wound exudate absorbed by the chitosan non-woven fabric, the thickness of which is 15mm, and the porosity is 60%.

Embodiment 3

[0040] Hydrophobic zinc-containing chitosan non-woven fabric, using chitosan non-woven fabric with medium molecular weight (30000) and deacetylation degree of 70% as raw material, adopts propylene polymerization (polymerization rate 100%) to carry out the adsorption of zinc ions, so that The zinc adsorption amount reaches 50mg / g; the hydrophobic zinc-containing chitosan nonwoven fabric is composed of 15 layers, and its thickness is about 10mm, which ensures that the zinc release amount remains at 0.8μmol / cm 2 ; The hydrophilic polyurethane is used to absorb the wound exudate absorbed by the chitosan non-woven fabric, the thickness of which is 18mm, and the porosity is 80%.

[0041] If the chitosan containing metal ion antibacterial agent is chitosan containing copper ions, the technical solution provided by the present invention is described in detail as follows: hydrophobic copper-containing chitosan non-woven fabric, using medium molecular weight (30000~60000), desorbed Chit...

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Abstract

The invention relates to a wound surface patch which contains a metal ion antibacterial agent, is used for closed negative pressure treatment of a wound surface and has antibacterial and tissue repair promoting effects, and a preparation method for the patch. The wound surface patch comprises a sponge layer, a negative pressure suction tube which stretches into the sponge layer, and a non-woven fabric combined with the sponge layer. The invention provides the negative pressure treatment wound surface patch which contains the metal ion antibacterial agent and ensures that negative pressure drainage is effectively implemented and antibacterial and tissue healing promoting comprehensive treatment effects are achieved simultaneously so as to improve the treatment effect of chronic and refractory wound surfaces such as diabetic ulcer and the like, and the preparation method for the patch.

Description

technical field [0001] The invention belongs to the field of medical supplies, and relates to a wound patch for treating wounds, in particular to a wound patch containing a metal ion antibacterial agent and used for sealing negative pressure treatment wounds, which has both antibacterial and tissue repair functions and a preparation method thereof. Background technique [0002] Chitosan (chitosan, CS) is a water-soluble polyglucosamine obtained by deacetylating chitin as a raw material in concentrated alkali. It is completely derived from natural materials, which is convenient to obtain and low in cost. In terms of physical and chemical properties, chitosan has good biocompatibility, is non-toxic to the human body, is biodegradable, and also has hemostatic, antibacterial and film-forming properties, so it is widely used in food, medicine, textile, printing and dyeing, cosmetics and environmental protection. and other fields have a wide range of uses. [0003] The medical a...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44A61F13/02D06M14/06D06M11/00D06M101/10
Inventor 李靖洪涛李跃军荀文兴李望舟蒋立
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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