Brassinolide water dispersible granule/tablet and preparation method thereof

A technology of brassinolide and dispersible granules, which is applied in botany equipment and methods, biocides, animal repellents, etc., and can solve problems such as environmentally unfriendly organic solvents, inconvenient transportation of emulsifiable concentrates, and inaccurate use and measurement , to achieve the effects of less drug damage, good storage stability, and fast disintegration speed

Inactive Publication Date: 2012-05-16
安阳全丰生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the small size of the powder, it is easy to drift and the measurement is inaccurate, which brings many adverse effects to the operator and the surrounding environment during production and use.
The emulsifiable concentrate generally has problems such as inconvenient transportation, inaccurate usage measurement, and a large amount of organic solvents that are not friendly to the environment.

Method used

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  • Brassinolide water dispersible granule/tablet and preparation method thereof
  • Brassinolide water dispersible granule/tablet and preparation method thereof
  • Brassinolide water dispersible granule/tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1001

[0030] The preparation of embodiment 10.01% brassinolide water-dispersible granules

[0031] The selection and ratio of original drug and auxiliary agent are: 95% brassinolide original drug 0.011% (0.01%), the dispersant is sodium methylene dimethyl naphthalene sulfonate 2.0%, calcium lignosulfonate 4.0%, wetting agent sodium lauryl sulfate 2.0%, disintegrating agent is sodium carboxymethyl starch 9.0%, binder is dextrin 5.0%, filler is attapulgite to make up 100%

[0032] According to the above proportions, the dosage of each component is calculated, weighed, and mixed evenly; the formula is granulated by ultrafine / jet milling, dried, granulated, and selected. Product testing is carried out according to the quality control indicators of water-dispersible granules, including the content of active ingredients, wetting time, disintegration rate, suspension rate, foaming property, sieve analysis, shedding rate, pH range and thermal storage stability, etc. The specific method is ...

Embodiment 1

[0038] The brassinolide water-dispersible granule performance index prepared by embodiment 1 is: brassinolide content 0.0102%, wettability qualified (18 seconds), disintegration (46 seconds), foaming property qualified (22 milliliters ), moisture 1.5%, pH value 6.6, suspension rate 88%, shedding rate 0.8%, sieve analysis 99%, thermal storage stability qualified, active ingredient decomposition rate 0.3%.

Embodiment 2001

[0039] The preparation of embodiment 20.01% brassinolide water-dispersible tablet

[0040] The selection and ratio of the original drug and the auxiliary agent are: 0.011% (0.01%) of the original drug of 95% brassinolide, the dispersant is 3.0% of naphthalene sulfonate formaldehyde condensate, 3.0% of calcium lignosulfonate, The wetting agent is sodium lauryl sulfate 2.0%, the disintegrant is sodium carboxymethyl starch 13.0%, the binder is polyvinyl alcohol 5.0%, and the filler is talcum powder to make up 100%.

[0041] According to the above proportions, the dosage of each component is calculated, weighed, and mixed evenly; the formula is granulated by ultrafine / jet milling, dried, pressed into tablets, and selected. Product testing is carried out according to the quality control indicators of water-dispersible tablets, including the content of active ingredients, disintegration time limit, suspension rate, foaming property, sieve analysis, powder and fragment rate, pH range...

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Abstract

The invention discloses a brassinolide water dispersible granule/tablet and a preparation method thereof. The brassinolide water dispersible granule/tablet comprises the following raw materials by weight percent: 0.001-1% of brassinolide, 0.5-15% of dispersing agent, 0.5-8% of wetting agent, 0.1-30% of disintegrating agent, 0-10% of binder and the balance of filler. The preparation method comprises the following steps of: mixing the raw materials used for preparing the brassinolide water dispersible granule/tablet, pelleting after ultramicro/air jet pulverization, drying, carrying out granule-straightening/tabletting, selecting, and detecting to obtain the product. The brassinolide water dispersible granule/tablet in the invention is safe to environment, people and livestock and other beneficial organisms, has small possibility of generating phytotoxicity, can be metered accurately, and is convenient to use; and the disintegration speed is fast, the storing stability is excellent, the preparation process is simple and the brassinolide water dispersible granule/tablet is suitable for industrial production and promotion and application in a large area in agriculture.

Description

Technical field: [0001] The invention relates to a water-dispersible granule / or tablet of a plant growth regulator and a preparation method thereof, in particular to a brassinolide water-dispersible granule / or tablet and a preparation method thereof. Background technique: [0002] Brassinolide has multiple functions such as strong rooting, promoting growth, raising seedlings, strengthening seedlings, preserving seedlings, promoting fruit expansion and early maturity, reducing disease and phytotoxicity, coordinating nutritional balance, drought and cold resistance, and enhancing crop stress resistance. It has a remarkable effect on the phenomenon of dead seedlings, rotten roots, standing dry, and damping caused by heavy cropping, disease, pesticide damage, freezing damage and other reasons. It is suitable for food crops, economic crops, vegetables and fruits, etc., to promote growth, increase yield and improve quality. [0003] Structural formula: [0004] Molecular formu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/22A01N25/14A01N25/34A01P21/00
CPCY02A40/10
Inventor 徐雪松杨晓庆闫振领张廷琴万小瑞马彦芳
Owner 安阳全丰生物科技有限公司
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