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Preparation method for medical metal implant material porous niobium

An implant material and a technology of porous niobium, which is applied in the field of preparation of porous niobium implant materials, can solve the problems of insufficient purity of finished products, reduced biological safety, carbon skeleton residues, etc., and achieve reduced impurity content, improved purity, and easy decomposition Effect

Inactive Publication Date: 2013-09-18
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitations of its preparation method, the purity of the obtained finished product is not enough, and there are carbon skeleton residues, resulting in a decrease in biological safety

Method used

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  • Preparation method for medical metal implant material porous niobium
  • Preparation method for medical metal implant material porous niobium
  • Preparation method for medical metal implant material porous niobium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Weigh 8 g of ethyl cellulose and put it into a container containing 240 ml of absolute ethanol; place it on an electric stove to heat and stir to make it an ethyl cellulose ethanol solution. Use a 200g balance to weigh 60g of niobium powder with an average particle size of less than 43 microns and an oxygen content of less than 0.1% and 4g of starch, add 15ml of cooled ethyl cellulose ethanol solution, stir and mix evenly to make a mixed slurry. Use 10×10×30mm porous polyurethane foam (average pore diameter is 0.48mm, density 0.025g / cm 3 , hardness 50°) into it and pour until the pores of the polyurethane foam are filled with slurry, then use clips to take out the polyurethane foam that has absorbed the slurry and put it into a porcelain plate. Dry in a vacuum drying oven at a drying temperature of 60° C., a drying time of 6 hours, and a vacuum degree of 1 Pa. Degreasing treatment: the vacuum degree is lower than 1×10 -3 Pa, temperature 600°C, holding time ...

Embodiment 2

[0034] Example 2: Weigh 6 g of ethyl cellulose and put it into a container containing 200 ml of absolute ethanol; place it on an electric stove to heat and stir to make it an ethyl cellulose ethanol solution. Use a 200g balance to weigh 40g of niobium powder with an average particle size of less than 43μm and an oxygen content of less than 0.1% and 2.15g of starch, add 10ml of ethyl cellulose ethanol solution, stir and mix evenly to make a mixed slurry. Use 10×10×25mm porous polyurethane foam (average pore diameter is 0.56mm, density 0.030g / cm 3 , hardness 60 0 ) into it and pour until the pores of the polyurethane foam are filled with slurry, then use a clamp to take out the polyurethane foam that has absorbed the slurry and put it into a porcelain plate. Dry in a vacuum drying oven at a drying temperature of 70°C, a drying time of 4 hours, and a vacuum degree of 1×10 -2 Pa. Degreasing treatment: the vacuum degree is lower than 1×10 -3 Pa, temperature 800°C, holding time ...

Embodiment 3

[0037] Example 3: Weigh 9 g of ethyl cellulose and put it into a container containing 220 ml of absolute ethanol; place it on an electric stove to heat and stir to make it an ethyl cellulose ethanol solution. Use a 200g balance to weigh 45g of niobium powder with an average particle size of less than 43μm and an oxygen content of less than 0.1% and 2.5g of starch, add 12ml of ethyl cellulose ethanol solution, stir and mix evenly to make a mixed slurry. Use 8×8×25mm porous polyurethane foam (average pore size is 0.70mm, density 0.035g / cm 3 , hardness 70°) into it and pour until the pores of the polyurethane foam are filled with slurry, then use a clamp to take out the polyurethane foam filled with niobium powder slurry and put it into a porcelain plate. Dry in a vacuum drying oven, the drying temperature is 68 ° C, the drying time is 6 hours, and the vacuum degree is kept at 1×10 -1 Pa. Degreasing treatment: the vacuum degree is lower than 1×10 -3 Pa, temperature 700°C, hold...

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Abstract

The invention provides a preparation method for a medical metal implant material porous niobium. According to the invention, a solution prepared from ethyl cellulose which is used as an organic binder and anhydrous ethanol which is used as a dispersant and mixed powder prepared from starch and niobium powder which has an average particle size of less than 43 mu m and oxygen content of less than 0.1% are used to prepare niobium powder slurry which is casted and dipped into an organic foam; the organic foam is dried and then is subjected to degreasing under the protection of an inert gas atmosphere and to sintering in vacuum so as to prepare a porous sintered body, sintered niobium powder particles mutually have a sintering neck structure, and after annealing in vacuum and normal post-treatment, porous niobium is prepared; wherein, the content of starch in the mixed powder of metallic niobium powder and starch is 5 to 10%. The medical metal implant material porous niobium prepared in the invention has excellent bio-compatibility and bio-safety; meanwhile, the porous niobium has a sintering neck structure, which enables mechanical properties of the porous niobium like ductility, etc., to be improved; the invention provides a good method for convenient and effective application of porous niobium in the field of medical metal implantation.

Description

technical field [0001] The invention relates to a preparation method of porous niobium as a medical implant material, in particular to a preparation method of a porous niobium implant material suitable for light-bearing parts of a human body. Background technique [0002] Porous medical metal implant materials have important and special purposes such as treating bone tissue trauma and femoral tissue necrosis. The common materials of this type include porous metal stainless steel and porous metal titanium. As a porous implant material used in the treatment of bone tissue trauma and femoral tissue necrosis, its porosity should reach 30-80%, and the pores should be all connected and uniformly distributed, or partially connected and uniformly distributed according to the needs, so that it can be connected with The growth of bone tissue in the human body is consistent, and the weight of the material itself is reduced, so that it is suitable for human implantation. [0003] The r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/56B22F3/11
Inventor 阮建明叶雷谢健全节云峰王志强冯华周健
Owner CHONGQING RUNZE PHARM CO LTD
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