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Gamma-polyglutamic acid/hydroxyapatite composite material and preparation method thereof

A technology of hydroxyapatite and polyglutamic acid, which is applied in the field of biomedicine, can solve the problems of not preparing γ-polyglutamic acid/hydroxyapatite composite materials, etc., and achieve the improvement of osseointegration ability, mechanical properties, The effect of promoting repair

Active Publication Date: 2013-06-19
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] There is no report on the preparation of γ-polyglutamic acid / hydroxyapatite composites

Method used

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  • Gamma-polyglutamic acid/hydroxyapatite composite material and preparation method thereof

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Experimental program
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Embodiment 1

[0017] According to the amount of calcium ions and phosphorus ions in the chemical formula of hydroxyapatite, that is, the molar ratio of Ca: P=5: 3, calcium chloride and sodium dihydrogen phosphate are selected to prepare calcium ion solutions with a concentration of 10 mol / L and a concentration of 6mol / L phosphorus ion solution. The mass fraction is 2.0% gamma-polyglutamic acid aqueous solution, the molar ratio of carboxyl and calcium ion in the gamma-polyglutamic acid solution is the ratio of 6: 1, the gamma-polyglutamic acid aqueous solution is added to the calcium ion solution, the reaction was stirred at room temperature for 5 hours. In the reaction solution of γ-polyglutamic acid and calcium ions, add phosphorus ion solution of the same volume as the calcium ion solution drop by drop, stir while adding, control the reaction pH value to 8.5-10, after the dropwise addition is completed, then Stir for 24 hours, then age for two days, that is, stand at room temperature, so...

Embodiment 2

[0019] According to the amount of calcium ions and phosphorus ions in the chemical formula of hydroxyapatite, i.e. the molar ratio of Ca:P=5:3, choose calcium carbonate and potassium dihydrogen phosphate to prepare calcium ion solutions with a concentration of 40mol / L and a concentration of 24mol respectively. / L of phosphorus ion solution. The mass fraction is 2.0% gamma-polyglutamic acid aqueous solution, the molar ratio of carboxyl and calcium ion in the gamma-polyglutamic acid solution is the ratio of 4:1, the gamma-polyglutamic acid aqueous solution is added to the calcium ion solution, the reaction was stirred at room temperature for 4 hours. In the reaction solution of γ-polyglutamic acid and calcium ions, add phosphorus ion solution of the same volume as the calcium ion solution drop by drop, stir while adding, control the reaction pH value to 8.5-10, after the dropwise addition is completed, then Stir for 24 hours, then age for two days to obtain a γ-polyglutamic aci...

Embodiment 3

[0021] According to the amount of calcium ions and phosphorus ions in the chemical formula of hydroxyapatite, i.e. the molar ratio of Ca:P=5:3, choose calcium hydroxide and dipotassium hydrogen phosphate to configure the calcium ion solution and concentration of 60mol / L respectively 36mol / L phosphorus ion solution. The mass fraction is 6.0% gamma-polyglutamic acid aqueous solution, the molar ratio of carboxyl and calcium ion in the gamma-polyglutamic acid solution is the ratio of 2: 1, the gamma-polyglutamic acid aqueous solution is added to the calcium ion solution, the reaction was stirred at room temperature for 3 hours. In the reaction solution of γ-polyglutamic acid and calcium ions, add phosphorus ion solution of the same volume as the calcium ion solution drop by drop, stir while adding, control the reaction pH value to 8.5-10, after the dropwise addition is completed, then Stir for 24 hours, then age for two days to obtain a γ-polyglutamic acid / hydroxyapatite solution...

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Abstract

The invention provides a novel gamma-polyglutamic acid / hydroxyapatite composite material and a preparation method thereof. The method comprises the following steps of: preparing calcium ion and phosphorous ion solutions; adding a gamma-polyglutamic acid solution into the calcium ion solution to react; dropwise adding the phosphorous ion solution; and preparing the composite material by virtue of stirring, aging, compression molding and lyophilizing. The invention is a novel method of preparing the novel gamma-polyglutamic acid / hydroxyapatite composite material by adding gamma-polyglutamic acid into hydroxyapatite by virtue of an in-situ polymerization method. The novel gamma-polyglutamic acid / hydroxyapatite composite material prepared by the method of the invention is transparent oyster white with bending strength of 135.0MPa and remarkably improved mechanical performance. The composite can guarantee that: calcium ions and phosphorus ions in the hydroxyapatite in a bone repairing process are released from the gamma-polyglutamic acid constantly, smoothly and slowly, the bone bonding capability of the hydroxyapatite composite material can be improved, and bone defect repairing is promoted.

Description

Technical field: [0001] The invention belongs to the field of biomedicine, and in particular relates to a novel γ-polyglutamic acid / hydroxyapatite composite material and a preparation method thereof. Background technique: [0002] γ-polyglutamic acid (γ-PGA) is an amino acid polymer that can be biosynthesized by microorganisms in large quantities. It is composed of D-type or L-type glutamic acid linked by γ-amide bonds. Usually it is composed of about 5,000 glutamic acid monomers, and its relative molecular mass is generally between 100,000 and 1 million. As a water-soluble, biodegradable, non-toxic and biocompatible polymer, γ-polyglutamic acid has the functions of thickening, emulsifying, gelling, film forming, moisturizing and bonding, and can be used with Other materials are aggregated to form new composite materials. In the field of biomedicine, they can be used as drug carriers, hemostatic agents, biological adhesives, and tissue repair, and have great application pro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L77/02C08K3/32A61L27/18A61L27/12
Inventor 疏秀林施庆珊冯劲欧阳友生陈仪本
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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