Glimepiride orally disintegrating medicine composition
A technology of oral disintegration and glimepiride, which is applied in the field of pharmaceuticals in the field of medicine, can solve the problems of low dissolution rate and poor water solubility, and achieve high bioavailability, stable quality and good taste
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Embodiment 1
[0084] The orally disintegrating pharmaceutical composition of glimepiride described in every 1000 tablets is composed of:
[0085] Glimepiride 2g
[0086] Polyacrylic resin S100 6g
[0087] 95% ethanol 60ml
[0088] Mannitol 40g
[0089] Ethylcellulose 5g
[0090] Croscarmellose Sodium 8g
[0091] 10% pregelatinized starch solution appropriate amount
[0092] Croscarmellose Sodium 4g
[0093] Magnesium Stearate 1g
[0094] Preparation Process:
[0095] 1) Disperse polyacrylic acid resin S100 in 95% ethanol of prescription quantity;
[0096] 2) Dissolve the prescribed amount of glimepiride in step 1), and stir for 30 minutes to completely dissolve;
[0097] 3) Rotate the sample in step 2) at 60±2°C for about 3 hours to obtain the inclusion compound of glimepiride;
[0098] 4) Measure the content of glimepiride inclusion compound, and convert the dosage of glimepiride inclusion compound;
[0099] 5) Weigh the inclusion compound of glimepiride, mannitol, ethyl cellulo...
Embodiment 2
[0107] The orally disintegrating pharmaceutical composition of glimepiride described in every 1000 tablets, its formula consists of:
[0108] Glimepiride 4g
[0109] Polyacrylic resin S100 12g
[0110] 95% ethanol 120ml
[0111] Mannitol 40g
[0112] Ethylcellulose 5g
[0113] Croscarmellose Sodium 8g
[0114] 10% pregelatinized starch solution appropriate amount
[0115] Croscarmellose Sodium 4g
[0116] Magnesium Stearate 1g
[0117] Preparation process: with embodiment 1.
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