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Glimepiride orally disintegrating medicine composition

A technology of oral disintegration and glimepiride, which is applied in the field of pharmaceuticals in the field of medicine, can solve the problems of low dissolution rate and poor water solubility, and achieve high bioavailability, stable quality and good taste

Inactive Publication Date: 2013-06-12
JIANGSU GAOSHIDA ELECTRIC TOOL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The invention with application number CN200510200565.5 provides a glimepiride dispersible tablet and its preparation method; it acts on pancreatic β-cells, blocks ATP-sensitive potassium channels, and stimulates insulin secretion; it can be used alone to control diet, Patients with ineffective exercise can also be used together with other hypoglycemic drugs or insulin. It has the characteristics of high efficiency, safety, low dose, and low toxicity. The dispersible tablet preparation provided by the invention solves the problems of the existing glimepiride ordinary tablet The problem of poor water solubility and low dissolution rate has the characteristics of rapid onset and remarkable curative effect

Method used

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  • Glimepiride orally disintegrating medicine composition
  • Glimepiride orally disintegrating medicine composition
  • Glimepiride orally disintegrating medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] The orally disintegrating pharmaceutical composition of glimepiride described in every 1000 tablets is composed of:

[0085] Glimepiride 2g

[0086] Polyacrylic resin S100 6g

[0087] 95% ethanol 60ml

[0088] Mannitol 40g

[0089] Ethylcellulose 5g

[0090] Croscarmellose Sodium 8g

[0091] 10% pregelatinized starch solution appropriate amount

[0092] Croscarmellose Sodium 4g

[0093] Magnesium Stearate 1g

[0094] Preparation Process:

[0095] 1) Disperse polyacrylic acid resin S100 in 95% ethanol of prescription quantity;

[0096] 2) Dissolve the prescribed amount of glimepiride in step 1), and stir for 30 minutes to completely dissolve;

[0097] 3) Rotate the sample in step 2) at 60±2°C for about 3 hours to obtain the inclusion compound of glimepiride;

[0098] 4) Measure the content of glimepiride inclusion compound, and convert the dosage of glimepiride inclusion compound;

[0099] 5) Weigh the inclusion compound of glimepiride, mannitol, ethyl cellulo...

Embodiment 2

[0107] The orally disintegrating pharmaceutical composition of glimepiride described in every 1000 tablets, its formula consists of:

[0108] Glimepiride 4g

[0109] Polyacrylic resin S100 12g

[0110] 95% ethanol 120ml

[0111] Mannitol 40g

[0112] Ethylcellulose 5g

[0113] Croscarmellose Sodium 8g

[0114] 10% pregelatinized starch solution appropriate amount

[0115] Croscarmellose Sodium 4g

[0116] Magnesium Stearate 1g

[0117] Preparation process: with embodiment 1.

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Abstract

The invention provides glimepiride orally disintegrating tablets. The orally disintegrating tablets are prepared by an inclusion technology, effectively solve the problems about the taste and disintegration of a main medicine, are convenient to operate, transport and store, have broad application range, and are suitable for large-scale production.

Description

technical field [0001] The invention relates to medicines in the field of medicine, in particular to a glimepiride orally disintegrating pharmaceutical composition and a preparation method thereof. Background technique [0002] Sulfonylureas were first used in the treatment of type 2 diabetes 50 years ago. Until now, although they have undergone two generations of updates, they are still the most commonly used drugs to treat type 2 diabetes. Glyburide, glipizide, and glimepiride are the latest generation of sulfonylurea hypoglycemic drugs, which have similar hypoglycemic effects to the first generation of sulfonylureas. And the effect is stronger, the tolerance is better, and the side effects are smaller. It has been reported in the literature that they have different binding abilities to sulfonylurea receptors on islet β cells, and glimepiride has a protective effect on myocardial ischemic preconditioning. Clinical studies have shown that 1-8mg of glimepiride per day can...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/64A61K47/38A61K47/32A61P3/10
Inventor 张昊
Owner JIANGSU GAOSHIDA ELECTRIC TOOL CO LTD
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