Kit for screening and checking glucose-6-phosphate dehydrogenase (G6PD) deficiency of neonates and preparation method for kit

A hexaphosphate dehydrogenase and glucose technology, which is applied to a kit for screening neonatal glucose hexaphosphate dehydrogenase deficiency and its preparation field, can solve the problems of high false positive rate and low accuracy rate of blood samples, and achieves The effect of reducing false positive rate, high accuracy and low cost
CN102519925AActive Publication Date: 2012-06-27GUANGZHOU FENGHUA BIOENG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGZHOU FENGHUA BIOENG
Publication Date
2012-06-27

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Abstract

The invention discloses a kit for screening and checking glucose-6-phosphate dehydrogenase (G6PD) deficiency of neonates and a preparation method for the kit. The kit for screening and checking the glucose-6-phosphate dehydrogenase (G6PD) deficiency of the neonates consists of substrate reagent dry powder, a substrate redissolved reagent, a copper reagent, a reaction board and filter paper dried blood spot quality control material. The detection result of the kit is high in accuracy and sensitivity, and the kit has the advantages of high stability, economy, simplicity, high efficiency and thelike; when the kit is applied to screening and checking for the neonates, the relevance ratio of heterozygote is improved; and the judgment accuracy is improved.
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Description

technical field

[0001] The invention relates to the field of detection kits, in particular to a kit for screening neonatal glucose-6-phosphate dehydrogenase deficiency and a preparation method thereof. Background technique

[0002] Glucose-6-phosphate dehydrogenase deficiency is a group of heterogeneous diseases caused by a significant deficiency of erythrocyte glucose-6-phosphate dehydrogenase (G6PD), commonly known as "faba bean disease", and is the most common inherited enzyme deficiency disease. Glucose-6-phosphate dehydrogenase deficiency (Glucose-6-phosphate dehydrogenase G6PD) is one of the important housekeeping enzymes of almost all high and low organisms, with a molecular weight of 59kDa, and its active form consists of 2 or 4 subunits, each Each subunit contains 515 amino acids. The enzyme catalyzes the rate-limiting step of the hexose phosphate bypass pathway in the process of cellular energy metabolism, and in the process reduces NADP (coenzyme Ⅱ) to NADPH, whi...

Claims

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