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Method for preparing medical titanium material with high anti-cancer and antibacterial properties

A kind of titanium material, good technology, applied in the field of preparation of functionalized titanium material, can solve the problems of inability to achieve antibacterial effect, looseness, etc., achieve good anticancer and antibacterial performance, low cost, and simple operation

Inactive Publication Date: 2014-04-30
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there may still be cancer cells that have not been completely removed near the bone implant implanted after surgery, and the inflammatory response caused by bacteria can easily lead to loosening after implantation, therefore, it is desirable to develop a bone implant with good anticancer and antibacterial properties. Implant material is very important
[0003] Previous research results have shown that appropriate nanotube diameter and tube length can promote cell function; titanium dioxide nanotubes can be used as drug carriers, and titanium dioxide nanotubes loaded with antibiotics have shown good antibacterial properties by freeze-vacuum drying method, but due to Rapid release of antibiotics, cannot achieve long-lasting antibacterial effect

Method used

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  • Method for preparing medical titanium material with high anti-cancer and antibacterial properties
  • Method for preparing medical titanium material with high anti-cancer and antibacterial properties
  • Method for preparing medical titanium material with high anti-cancer and antibacterial properties

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1. Preparation of medical titanium material with good anticancer and antibacterial properties

[0027] a. Pretreatment of titanium materials: ultrasonically clean the titanium materials with acetone, isopropanol and methanol for 20 minutes, then wash with deionized water for 3 times, dry at 40°C, and set aside;

[0028] b. Construction of titanium dioxide nanotube arrays: dissolving ammonium fluoride with a glycerol-water mixture with a volume ratio of 1:1 to make a solution with a concentration of 0.27mol / L as the electrolyte; use the titanium material obtained in step a as The anode, platinum as the cathode, is placed in the above-mentioned ammonium fluoride electrolyte, and the anodic oxidation reaction is carried out at a constant voltage of 30V for 30 minutes; the treated titanium material is washed 5 times with deionized water, dried at 40°C, and used for later use; the obtained titanium material is referred to as is "titanium dioxide nanotubes"; ...

Embodiment 2

[0032] Embodiment 2. Preparation of medical titanium material with good anticancer and antibacterial properties

[0033] a. Pretreatment of titanium materials: ultrasonically clean the titanium materials with acetone, isopropanol and methanol for 20 minutes, then wash with deionized water for 3 times, dry at 40°C, and set aside;

[0034] b. Construction of titanium dioxide nanotube arrays: dissolving ammonium fluoride with a glycerol-water mixture with a volume ratio of 1:1 to make a solution with a concentration of 0.25mol / L as the electrolyte; use the titanium material obtained in step a as Anode, platinum as cathode, placed in the above-mentioned ammonium fluoride electrolyte, anodic oxidation reaction at a constant voltage of 30V for 45 minutes; the treated titanium material was washed 5 times with deionized water, dried at 40°C, and used for later use; the obtained titanium material is referred to as is "titanium dioxide nanotubes";

[0035]c. Loading of selenium n...

Embodiment 3

[0037] Embodiment 3. Preparation of medical titanium material with good anticancer and antibacterial properties

[0038] a. Pretreatment of titanium materials: ultrasonically clean the titanium materials with acetone, isopropanol and methanol for 20 minutes, then wash with deionized water for 3 times, dry at 40°C, and set aside;

[0039] b. Construction of titanium dioxide nanotube arrays: dissolving ammonium fluoride with a glycerol-water mixture with a volume ratio of 1:1 to make a solution with a concentration of 0.30 mol / L as the electrolyte; use the titanium material obtained in step a as Anode, platinum as cathode, placed in the above-mentioned ammonium fluoride electrolyte, anodic oxidation reaction at a constant voltage of 30V for 60 minutes; the treated titanium material was washed 5 times with deionized water, dried at 40°C, and used for later use; the obtained titanium material is referred to as is "titanium dioxide nanotubes";

[0040] c. Loading of selenium...

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Abstract

The invention relates to a method for preparing a medical titanium material with high anti-cancer and antibacterial properties. The method comprises the following steps of: firstly, generating highly regular and ordered titanium dioxide nanotube arrays on the surface of the titanium material by an anodic oxidation method; secondly, generating selenium nanoparticles in titanium dioxide nanotubes in situ by an electrochemical deposition method; and finally, modifying multi-layer chitosan on the surface of the titanium material by a spin-coating method to obtain the medical titanium material with high anti-cancer and antibacterial properties. The method is easy to operate and low in cost, special equipment is not needed, and tests prove that the obtained product can inhibit the growth of bone tumor cells for a long time and promote the growth of normal osteoblasts simultaneously and has high antibacterial property.

Description

technical field [0001] The invention belongs to the field of medical materials and relates to a preparation method of a functionalized titanium material. Background technique [0002] Titanium and titanium alloys are commonly used medical metal materials. Because of their elastic modulus similar to that of human bone, excellent corrosion resistance, good biocompatibility and processing performance, they have been used in dental implants and teeth since the 1970s. It is widely used in stents, bone implants and artificial joints. The clinical treatment of bone cancer is usually to replace the cancerous bone with bone implants. Since there may still be cancer cells that have not been completely removed near the bone implant implanted after surgery, and the inflammatory response caused by bacteria can easily lead to loosening after implantation, therefore, it is desirable to develop a bone implant with good anticancer and antibacterial properties. Implant material is very impo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C25D11/26C25D9/08B05C11/08A61L27/34A61L27/06
Inventor 蔡开勇陈秀勇方佳佳来敏
Owner CHONGQING UNIV
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