Hollow polyphosphazenes microsphere with magnetic particles embedded in casing layer and preparation method thereof

A magnetic particle and polyphosphazene technology, which is applied in the field of biomaterials and new materials, can solve the problems of dispersing inside the hollow ball and destroying the outer polymer structure, etc., and achieves controllable inner diameter, highly cross-linked chemical structure, and easy operation Effect

Inactive Publication Date: 2012-07-18
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although magnetic composite microspheres with a sandwich structure can theoretically obtain magnetic hollow polymer microspheres by removing the inner polymer, the structure of the outer polymer is often destroyed when the inner polymer is removed during actual operation. Moreover, the magnetic particles in the obtained magnetic hollow polymer microspheres are dispersed inside the hollow spheres, rather than embedded in the shell polymer matrix.

Method used

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  • Hollow polyphosphazenes microsphere with magnetic particles embedded in casing layer and preparation method thereof
  • Hollow polyphosphazenes microsphere with magnetic particles embedded in casing layer and preparation method thereof
  • Hollow polyphosphazenes microsphere with magnetic particles embedded in casing layer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Add 0.04 g of polystyrene microspheres with an average particle size of 600 nm into a single-mouth bottle containing 60 mL of absolute ethanol, and place the single-mouth bottle in an ultrasonic reactor for 10 minutes to make the polystyrene microspheres dissolve in absolute ethanol. disperse evenly; then add 0.08 g hexachlorocyclotriphosphazene, 0.176 g 4,4′-dihydroxydiphenyl sulfone and 0.01 g Fe 3 o 4 (average particle size 10nm), disperse uniformly under ultrasonic conditions (100 W, 40 kHz), and finally add acid-binding agent 4 mL triethylamine, and ultrasonically react for 10 h at 40 °C. After the reaction, it was separated by centrifugation, washed twice with ethanol and deionized water, and vacuum-dried at 50°C for 24 hours to obtain composite microspheres with polystyrene as the core and polyphosphazene with embedded magnetic particles as the shell.

[0027] (2) Add the above-obtained composite microspheres with a core-shell structure into a container cont...

Embodiment 2

[0035] (1) Add 0.02 g of polystyrene microspheres with an average particle size of 400 nm into a single-mouth bottle containing 30 mL of absolute ethanol, and place the single-mouth bottle in an ultrasonic reactor for 10 minutes to make the polystyrene microspheres dissolve in absolute ethanol. disperse evenly; then add 0.01 g hexachlorocyclotriphosphazene, 0.02 g 4,4′-dihydroxydiphenyl sulfone and 0.005 g Fe 3 o 4 (average particle size 5nm), disperse uniformly under ultrasonic conditions (100 W, 40 kHz), and finally add acid-binding agent 1mL triethylamine, and ultrasonically react at 20°C for 10 h. After the reaction, it was separated by centrifugation, washed twice with ethanol and deionized water, and vacuum-dried at 70°C for 20 hours to obtain composite microspheres with polystyrene as the core and polyphosphazene with embedded magnetic particles as the shell.

[0036] (2) Add the above-obtained composite microspheres with a core-shell structure into a container contain...

Embodiment 3

[0039] (1) Add 0.1 g of polystyrene microspheres with an average particle size of 900 nm into a single-mouth bottle containing 300 mL of absolute ethanol, and place the single-mouth bottle in an ultrasonic reactor for 10 minutes to make the polystyrene microspheres dissolve in absolute ethanol. disperse evenly; then add 0.1 g hexachlorocyclotriphosphazene, 0.2 g 4,4′-dihydroxydiphenyl sulfone and 0.025 g Fe 3 o 4 (average particle size 50nm), disperse uniformly under ultrasonic conditions (100 W, 40 kHz), and finally add acid-binding agent 10mL triethylamine, and ultrasonically react at 60°C for 3 h. After the reaction, it was separated by centrifugation, washed twice with ethanol and deionized water, and vacuum-dried at 80°C for 12 hours to obtain composite microspheres with polystyrene as the core and polyphosphazene with embedded magnetic particles as the shell.

[0040] (2) Add the composite microspheres with a core-shell structure obtained above into a container containi...

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Abstract

The invention belongs to the technical field of new materials and biological materials and discloses a hollow polyphosphazenes microsphere with magnetic particles embedded in a casing layer and a preparation method thereof. The method comprises dispersing 0.02-0.1g of polystyrene microspheres into 30-300mL of ethanol; then adding 0.01-0.1g of phosphonitrilic chloride trimerl, 0.02-0.2g of 4,4'-phosphonitrilic chloride trimerl, 0.005-0.025g of magnetic particles and 1-10mL of triethylamine into the ethanol according to mass/volume ratio; after an ultrasonic reaction of 3-10 hours at the temperature of 20-60 DEG C, performing centrifugal separation, washing and drying to obtain a composite microsphere with polystyrene serving as a core and with polyphosphazenes serving as a casing, wherein the magnetic particles are embedded in the polyphosphazenes; and adding the obtained composite microspheres into tetrahydrofuran or carbon tetrachloride, evenly stirring the mixture, performing magnetic separation, drying a separated product for 12-24 hours, and obtaining the hollow polyphosphazenes microsphere with the magnetic particles embedded in the casing layer. The hollow polyphosphazenes microsphere has a unique structure that the magnetic particles are embedded inside the casing layer of the hollow microsphere, and the preparation method of the hollow polyphosphazenes microsphere withmagnetic particles embedded in the casing layer is simple in preparation process and simple and convenient to operate.

Description

technical field [0001] The invention belongs to the technical field of new materials and biological materials, and relates to a magnetic polymer microsphere, in particular to a hollow polyphosphazene microsphere with magnetic particles embedded in a shell and a preparation method thereof. Background technique [0002] Magnetic polymer microspheres are a new type of functional polymer material developed in the past two decades. It is a microsphere with certain magnetic properties and special structure formed by combining organic polymers and inorganic magnetic substances through appropriate methods. Due to its following characteristics: (1) small particle size effect; (2) good magnetic responsiveness and (3) easy modification of the surface of polymer microspheres, it has aroused widespread interest of researchers and has been initially applied to cell labeling and separation, immobilization of enzymes, targeted drug delivery, sustained drug release carriers, catalyst carrier...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L85/02C08K3/22B01J13/14C08G79/02A61K47/34B01J32/00B01J31/28B01J35/08C08G79/025
Inventor 付建伟许群王明环王旭哲张超
Owner ZHENGZHOU UNIV
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