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Medical new use of ursolic acid

A new use technology of ursolic acid, which is applied in the field of new medical uses of ursolic acid, can solve the problems of the use of analgesic drugs that have no public records in the literature, and achieve the effect of reducing side effects

Inactive Publication Date: 2012-08-15
WUHAN LIYUANHENG PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The existing medicinal use of ursolic acid is its use in suppressing tumors, and there is no document publicly documenting its use in analgesic drugs

Method used

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  • Medical new use of ursolic acid
  • Medical new use of ursolic acid
  • Medical new use of ursolic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Ursolic acid hot plate analgesic experiment

[0018] Materials and methods

[0019] Reagents: ursolic acid nano-liposome (90.6%, provided by Wuhan Lyric Pharmaceutical Technology Co., Ltd.), compound ammonium barbiturate injection (Tianjin Jinyao Amino Acid Co., Ltd., approved by the Chinese Medicine H12021217), 500mL physiological salt Aqueous solution (China Otsuka Pharmaceutical Co., Ltd., Zhunzi H1202006), picric acid, absolute ethanol (analytical grade, Tianjin Binhai Sidi Chemical Reagent Co., Ltd.). Take the ursolic acid nanoliposome freeze-dried powder injection, add an appropriate amount of water for injection into each bottle, until completely dissolved, and set aside.

[0020] Instruments: stopwatch, 501 super thermostat (Shanghai No. 2 Hardware Factory), hot plate apparatus, transparent glass cover, 1mL syringe (Shanghai Mishawa Medical Industry Co., Ltd.), 1μL syringe, LD electronic balance (Shenyang Longteng Electronics Co., Ltd.), quartz d...

Embodiment 2

[0033] Embodiment 2: ursolic acid analgesic acetic acid writhing experiment

[0034] Materials and methods

[0035] Reagents: ursolic acid nanoliposome (90.6%), compound ammonium barbiturate injection (Tianjin Jinyao Amino Acid Co., Ltd., approved by the Chinese Medicine H12021217), 1% glacial acetic acid (self-made, 99% glacial acetic acid added to distilled water Prepared), 500mL normal saline solution (China Otsuka Pharmaceutical Co., Ltd., Zhunzi H1202006), picric acid, triple distilled water (self-made), absolute ethanol (analytical grade, Tianjin Binhai Private Chemical Reagent Co., Ltd.). Take the ursolic acid nanoliposome freeze-dried powder injection, add an appropriate amount of water for injection into each bottle, until completely dissolved, and set aside.

[0036] Test drug method: preparation method: take ursolic acid (purity 99.7%, batch number 20090906, provided by Wuhan Lyric Robot Pharmaceutical Technology Co., Ltd.) and add Tween-80 in an appropriate amount...

Embodiment 3

[0048] Embodiment 3: ursolic acid formalin experiment

[0049] material method

[0050] Test drug method: preparation method: take ursolic acid (purity 99.7%, batch number 20090906, provided by Wuhan Lyric Robot Pharmaceutical Technology Co., Ltd.) and add Tween-80 in an appropriate amount, heat in a water bath at 80°C until completely dissolved, add water to dilute, Be made into the solution (UA crude drug) containing ursolic acid 3mg / ml for subsequent use.

[0051] Experimental reagents: ursolic acid nanoliposomes (90.6%), compound ammonium barbiturate injection (Tianjin Jinyao Amino Acid Co., Ltd., national drug approval H12021217), 1500mL physiological sodium chloride solution (China Otsuka Pharmaceutical Co., Ltd. , National Pharmaceutical Standard H1202006), picric acid, triple distilled water (self-made), absolute ethanol (analytical grade, Tianjin Binhai Private Chemical Reagent Co., Ltd.), formalin Animals and groups: 60 healthy adult female mice , weight 18-22g, go...

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Abstract

The invention discloses medical new use of ursolic acid, and the application of the ursolic acid in the preparation of analgesic drug. The structure of the ursolic acid is different from the structures of three major analgesic drugs such as the morphine alkaloid, the semi-synthesis biomedicine and the total-synthesis biomedicine, thereby being the novel compound with analgesic effect. Due to the analgesic effect of the ursolic acid in the process of tumor cure, the ursolic acid can be taken as an effective component to prepare the analgesic drugs. Due to the new use of the ursolic acid, the use level of the drug for treating cancer pain with large side effect can be properly reduced, so that the side effects of the other drugs can be reduced, and a new way can be provided for the cure of the cancer pain and the other diseases with pain symptom in the clinic application, therefore, the medical new use of the ursolic acid is important in medicine value, social benefit and economic benefit.

Description

technical field [0001] The present invention relates to a new application of ursolic acid, specifically a new medical application of ursolic acid. Background technique [0002] 1. Introduction to analgesics [0003] Pain is an unpleasant perception and emotion, a symptom of many diseases, it is associated with real and potential tissue damage, and has both physiological and psychological factors. There are two types of drugs commonly used for analgesia: one is antipyretic and analgesic drugs that inhibit prostaglandin biosynthesis, and is usually used for peripheral dull pain; the other is narcotic analgesics, which bind to opioid receptors It is usually used for severe pain, also referred to as analgesic. Analgesics can be divided into three categories according to structure and source: morphine alkaloids, semi-synthetic and fully synthetic biological drugs. Among them, synthetic analgesics are further divided into piperidines, aminoketones, benzomorphans, etc. according...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K9/127A61P29/00
Inventor 谢俊明白岩易以木
Owner WUHAN LIYUANHENG PHARMA TECH
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