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Antiphlogistic and analgesic traditional Chinese medicine extract and preparation method thereof

A technology of extract and traditional Chinese medicine, which is applied in the fields of analgesic Chinese medicine extract and its preparation, anti-inflammatory, Oleaceae Ash plant stem bark extract and its preparation, which can solve the problem of unstable quality, large toxic and side effects, and the use of Large dosage and other problems, to achieve the effect of low cost of raw materials, small toxic and side effects, and easy recycling

Active Publication Date: 2012-08-15
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Based on the above situation, aiming at the medicinal value and social effect of the extract of wax tree, the purpose of the invention is to develop and utilize the extract of wax tree with anti-inflammatory and analgesic effects and overcome the large toxic and side effects of western medicine and the large dosage and high purity of traditional Chinese medicine compound. However, due to the disadvantages of low quality and unstable quality, a single traditional Chinese medicine extract with small toxic and side effects, no dependence and addiction, small dosage, high purity, stable quality and significant curative effect is provided as an ideal treatment for anti-inflammatory and analgesic drug

Method used

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  • Antiphlogistic and analgesic traditional Chinese medicine extract and preparation method thereof
  • Antiphlogistic and analgesic traditional Chinese medicine extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The effect of embodiment 1 Chinese medicine extract on mouse ear swelling caused by xylene

[0018] 1 test material

[0019] 1.1 Experimental animals: Kunming mice, weighing 18-20 g, provided by Qinglongshan Animal Breeding Farm, Jiangning District, Nanjing.

[0020] 1.2 Positive control drug: aspirin, Jiangsu Pingguang Pharmaceutical Co., Ltd.

[0021] 1.3 Test reagents: methanol, ethanol, petroleum ether: Sinopharm Chemical Reagent Co., Ltd., analytically pure. Distilled water is provided by the laboratory of the school. Normal saline, configured in this laboratory.

[0022] 1.4 Preparation of traditional Chinese medicine extract 1

[0023] (1) Drying: the bark of the wax tree is dried in an oven at 80°C;

[0024] (2) pulverizing: the dry stem bark is pulverized, and crosses a 20-mesh sieve to obtain powder;

[0025] (3) Extraction: Take 2 kg of powder, add water 25 times the weight of the medicinal material powder for the first time, soak for 1 hour, decoct for...

Embodiment 2

[0059] The influence of embodiment 2 Chinese medicine extracts on mouse writhing reaction caused by acetic acid

[0060] 1 test material

[0061] 1.1 Experimental animals: Same as above.

[0062] 1.2 Positive control drugs: same as above.

[0063] 1.3 Test reagents: Same as above.

[0064] 2 Experimental methods

[0065] 50 mice, ♀ Half and half were randomly divided into 14 groups: negative control group (normal saline), positive control group (aspirin) and high, middle and low dose groups of Chinese herbal extracts 1, 2, 3 and 4. The mice in each group were intragastrically administered the corresponding drugs, once a day, for 7 consecutive days, 60 minutes after the last administration, 0.6% glacial acetic acid 10ml / kg body weight was injected into the abdominal cavity, and the number of writhing of the mice was observed within 15 minutes. The writhing is characterized by a concave abdomen, extended torso and hind legs, and raised arms. Calculation of inhibition rate...

Embodiment 3

[0073] The toxicity test of embodiment 3 Chinese medicine extract

[0074] 1 Experimental materials

[0075] 1.1 Animals: Same as above.

[0076] 1.2 Test reagents: Same as above.

[0077] 1.3 Preparation of traditional Chinese medicine extract 5

[0078] (1) Drying: the bark of the wax tree is dried in an oven at 40°C;

[0079] (2) pulverizing: the dry stem bark is pulverized, and crosses a 40-mesh sieve to obtain powder;

[0080] (3) Extraction: Take 2 kg of powder, add water 30 times the weight of the medicinal material powder for the first time, soak for 2 hours, decoct for 3 hours, filter; add water 8 times the weight of the medicinal material powder to the filter residue, and decoct for 1 hour , filter, and combine 2 filtrates;

[0081] (4) concentrating under reduced pressure: the filtrate is concentrated under reduced pressure into an extractum, so that the relative density of the extractum is 1.10g / ml;

[0082] (5) Purification: Add an equal volume of petroleum ...

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Abstract

The invention discloses an antiphlogistic and analgesic traditional Chinese medicine extract and a preparation method thereof, and particularly a fraxinus platypoda oliver bark extract and a preparation method thereof. The extract of the invention is obtained by extracting and purifying fraxinus platypoda oliver barks by water or alcohol with a mass percentage concentration of 20%-95%. The extract overcomes the disadvantages of great toxic and side effect for current western medicines and large dosage, low purity, and instable quality for traditional Chinese medicine compounds, has significant antiphlogistic and analgesic effects, and also has the characteristics of few administration amount, high purity, stable quality, less toxic and side effect, no dependency or addiction and the like. The extract is widely applicable to inflammatory diseases of various systems, organs and tissues of human body, and various pain caused by wound, surgery, fracture, and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to an anti-inflammatory and analgesic traditional Chinese medicine extract and a preparation method thereof, in particular to an extract of the stem bark of Oleaceae ash plant and a preparation method thereof. Background technique [0002] Anti-inflammatory and analgesic drugs are the most commonly used drugs in clinical practice. Mainly based on chemical synthesis at present, there are also a considerable number of traditional Chinese medicine compound preparations, but there are many shortcomings. [0003] Anti-inflammatory and analgesic chemical synthetic drugs mainly include steroids, such as dexamethasone and cortisone, which are powerful anti-inflammatory drugs, but there are serious side effects, such as long-term use can cause immunosuppression and osteoporosis; non-steroidal The main class is aspirin, which has good anti-inflammatory and analgesic effects, but can...

Claims

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Application Information

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IPC IPC(8): A61K36/63A61P29/00A61K135/00
Inventor 沈克姑江善祥
Owner NANJING AGRICULTURAL UNIVERSITY
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