Antibacterial nano silver modified polymeric micelle and preparation method thereof

A technology of polymer glue and nano-silver, which is applied in the direction of antibacterial drugs, medical preparations of non-active ingredients, pharmaceutical formulas, etc., can solve the problems of complicated preparation methods, inconvenient use, narrow use range, etc., and achieve simple preparation methods, Wide range of applications and the effect of avoiding the problem of solvent residue

Inactive Publication Date: 2012-09-19
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the nano-silver prepared above has certain antibacterial and antibacterial effects, its preparation method is relatively complicated, and the prepared nano-silver reagent and coating film components are complex, inconvenient to use, and the application area is also relatively narrow.
[0008] In

Method used

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  • Antibacterial nano silver modified polymeric micelle and preparation method thereof
  • Antibacterial nano silver modified polymeric micelle and preparation method thereof
  • Antibacterial nano silver modified polymeric micelle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0037] Example 1

[0038] (1) Macromolecular initiator PEO 43 -Br synthesis

[0039] Azeotropically distill 10g of flake PEO and 250mL of toluene to remove the excess water. The temperature of the system is lowered to room temperature and replaced with an ice-water bath. 2mL of triethylamine and 20mL of 2-bromoisobutyryl bromide in toluene can be added. , The reaction is carried out for 40h, filtration, extraction, collection of organic phase, drying, filtration, precipitation, suction filtration, and vacuum drying to obtain a white powdery macroinitiator PEO 43 -Br.

[0040] (2) ATRP synthetic polymer

[0041] 0.5g of macroinitiator PEO 43 -Br, 0.035g catalyst cuprous bromide (CuBr), 0.040g ligand PMDETA, 1.16g monomer dimethylaminoethyl methacrylate (DMA), 3.16g tert-butyl acrylate ( t BA) and 2mL methanol solvent were added to a 50mL round-bottomed flask, anhydrous and oxygen-free, under the protection of nitrogen or argon, atomic transfer radical polymerization (ATRP), temperature...

Example Embodiment

[0050] Example 2

[0051] (1) Macromolecular initiator PEO 43 -Br synthesis

[0052] Azeotropically distill 10g of flake PEO and 250mL of toluene to remove the excess water. The temperature of the system is reduced to room temperature, replaced with an ice water bath, and 2mL of triethylamine and 20mL of a toluene solution of 1.9mL of 2-bromoisobutyryl bromide can be added. The reaction is carried out for 40 hours, and the organic phase is collected by filtration, extraction, drying, filtration, precipitation, suction filtration, and vacuum drying to obtain a white powdery macroinitiator PEO 43 -Br.

[0053] (2) ATRP synthetic polymer

[0054] 0.5g of macroinitiator PEO 43 -Br, 0.035g catalyst cuprous bromide (CuBr), 0.040g ligand PMDETA, 1.16g monomer dimethylaminoethyl methacrylate (DMA), 2.06g tert-butyl acrylate ( t BA) and 2mL methanol solvent were added to a 50mL round-bottomed flask, anhydrous and oxygen-free, under the protection of nitrogen or argon, atomic transfer radical p...

Example Embodiment

[0059] Example 3

[0060] (1) Macromolecular initiator PEO 45 -Br synthesis

[0061] Azeotropically distill 10g of flake PEO and 250mL of toluene to remove the excess water. The temperature of the system is reduced to room temperature. Replace with an ice-water bath. Add 2mL of triethylamine and 20mL of a toluene solution of 1.0mL of 2-bromoisobutyryl bromide. The reaction is carried out for 40 hours, and the organic phase is collected by filtration, extraction, drying, filtration, precipitation, suction filtration, and vacuum drying to obtain a white powdery macroinitiator PEO 43 -Br.

[0062] (2) ATRP synthetic polymer

[0063] 0.5g of macroinitiator PEO 43 -Br, 0.035g catalyst cuprous bromide (CuBr), 0.040g ligand PMDETA, 0.86g monomer dimethylaminoethyl methacrylate (DMA), 3.56g tert-butyl acrylate ( t BA) and 2mL methanol solvent were added to a 50mL round-bottomed flask, anhydrous and oxygen-free, under the protection of nitrogen or argon, atomic transfer radical polymerization ...

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Abstract

The invention belongs to the high-molecular nano biomedical materials, and specifically relates to a polymeric micelle in which the antibacterial nano silver is deposited at the core, and a preparation method of the polymeric micelle. Amphiphilic block copolymers form the micelle in a self-assembly manner through a direct dissolution method, and then, nano silver is generated at the core of the micelle in situ. The micelle has biocompatibility and also has certain temperature and pH sensitivity, the core-shell structure of the micelle can package multiple drugs, and simultaneously, with the existence of nano silver, the micelle has the curative effects of sterilization and bacterial inhibition.

Description

technical field [0001] The invention belongs to the field of macromolecule nano biomedical materials, and in particular relates to an antibacterial nano-silver modified polymer micelle and a preparation method thereof. Background technique [0002] In recent years, the preparation of polymer micelles by self-assembly technology has attracted more and more attention from scientists from all over the world, because the polymer molecules that make up the micelles will change with the external pH, temperature, magnetic field, electric field, light and redox conditions. Corresponding changes in morphology, structure or composition endow polymer micelles with many excellent properties. Based on this, polymer micelles have broad application prospects in many fields, such as drug loading, gene carriers, Biomineralization templates, microreactors, bioscaffolds, etc. [0003] Amphiphilic block polymers can self-assemble in water to form micelles with a core-shell structure. Compared ...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K47/02A61K9/14A61K33/28A61P31/04C08L53/00C08K3/08C08F293/00C08F8/12C08J3/03
Inventor 杜建忠路航
Owner TONGJI UNIV
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