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Magnetic bone cement material and method for preparing magnetic bone cement

A bone cement and magnetic technology, applied in medical science, prosthesis and other directions, can solve the problems of short curing time of bone cement, poor clinical operation effect, unfavorable minimally invasive treatment, etc., and achieve extended curing time and good magnetic heat generation performance. , The effect of meeting the needs of clinical use

Inactive Publication Date: 2012-09-19
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bone cement made of pure brushite has a short curing time and poor injectability, which is not conducive to the realization of minimally invasive treatment.
At the same time, its degradation rate is too fast, and the clinical operation effect is poor

Method used

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  • Magnetic bone cement material and method for preparing magnetic bone cement
  • Magnetic bone cement material and method for preparing magnetic bone cement
  • Magnetic bone cement material and method for preparing magnetic bone cement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 (2#)

[0022] The magnetic bone cement material of this embodiment is composed of the following components by weight: 100 parts of a mixture of β-calcium phosphate and calcium dihydrogen phosphate monohydrate with a molar ratio of 1:1, and 5 parts of nanometer ferric oxide.

[0023] Wherein the β-calcium phosphate is prepared by the following method: take calcium carbonate powder and add water to reconcile into a slurry, and according to the Ca / P molar ratio of 1.49:1, add the slurry to a 1.42mol / L phosphoric acid solution under ultrasonic vibration and vigorous stirring , after adding, continue to ultrasonically fully react, filter the precipitate, wash and dry; calcinate the precipitate at 1100°C for 2 hours, the heating rate is 5°C / min, cool after calcining, and ball mill until it passes through a 200-mesh sieve.

[0024] Wherein nano ferric oxide is prepared by the following method: take FeSO 4 ·7H 2 O and FeCl 3 ·6H 2 O prepare ferrous salt and fer...

Embodiment 2

[0029] Embodiment 2 (3#)

[0030] The magnetic bone cement material and magnetic bone cement of the present embodiment are basically the same as those of Example 1, the difference being that the addition amount of nano-ferric oxide is 10 parts, and the specific embodiment content is: the magnetic bone cement material of the present embodiment, The composition is composed of the following components in parts by weight: 100 parts of a mixture of beta calcium phosphate and calcium dihydrogen phosphate monohydrate with a molar ratio of 1:1, and 10 parts of nano ferric oxide.

[0031] Wherein the β-calcium phosphate is prepared by the following method: take calcium carbonate powder and add water to reconcile into a slurry, according to the Ca / P molar ratio of 1.50:1, add the slurry to a 1.43mol / L phosphoric acid solution under ultrasonic vibration and vigorous stirring , after adding, continue to ultrasonically fully react, filter the precipitate, wash and dry; calcinate the precip...

Embodiment 3

[0037] Embodiment 3 (4#)

[0038] The magnetic bone cement material and the magnetic bone cement of this embodiment are basically the same as those of Example 1, the difference being that the addition amount of nano ferric oxide is 20 parts, and the specific embodiment content is as follows: the magnetic bone cement material of this embodiment, It is composed of the following components in parts by weight: 100 parts of a mixture of beta calcium phosphate and calcium dihydrogen phosphate monohydrate with a molar ratio of 1:1, and 20 parts of nano ferric oxide.

[0039] Wherein the β-calcium phosphate is prepared by the following method: take calcium carbonate powder and add water to reconcile into a slurry, and according to the Ca / P molar ratio of 1.52:1, add the slurry to a 1.45mol / L phosphoric acid solution under ultrasonic vibration and vigorous stirring , after adding, continue to ultrasonically fully react, filter the precipitate, wash and dry; calcinate the precipitate at 1...

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Abstract

The invention discloses a magnetic bone cement material and a method for preparing magnetic bone cement. The magnetic bone cement material consists of the following components in part by weight: 100 parts of mixture of beta calcium phosphate and monohydrate monocalcium phosphate in the molar ratio of 1:1, and 5 to 20 parts of nano ferroferric oxide. When the magnetic bone cement material is used, a solution of citric acid is used as solidifying liquid. Compared with pure brushite bone cement, the magnetic bone cement material has the advantages that the nano ferroferric oxide and the mixture of the calcium phosphate and the monohydrate monocalcium phosphate are used as a solid-phase matrix material of the magnetic bone cement, so that the solidifying time of the bone cement is prolonged, the syringeability of the bone cement is improved, and minimally invasive treatment can be realized easily; and the overquick degradation rate of the brushite is reduced, and the stability of the bone cement is improved. Meanwhile, the magnetic bone cement material is high in magnetic heating performance due to the adoption of the nano ferroferric oxide, and the performance of the bone cement material can be adjusted by adjusting the content of the nano ferroferric oxide. The magnetic bone cement material can meet the clinical using demand well and has promotional valve.

Description

technical field [0001] The invention relates to a magnetic bone cement and a preparation method of the magnetic bone cement, belonging to the technical field of biomedical inorganic materials. Background technique [0002] The postoperative recurrence of bone tumors is a major problem in the medical field. If there is a potentially malignant giant cell tumor of bone, the chance of recurrence is 10-50%. Even if extensive resection is used, reoperation or even amputation may be required for radical cure. Another example is that even with high-dose chemotherapy combined with surgery, primary osteosarcoma still has a recurrence rate of about 30%-40%. Relapse results in a 60%-70% 5-year survival down to 23%-29%. Bone tumor recurrence not only makes patients suffer more, but can even be life-threatening. Due to the recurrence of bone tumors, people put forward requirements for tumor treatment functions on bone repair materials that originally only had bone repair and reconstruc...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/12
Inventor 李光大冯书营薛云赵三团乔晓岚马建华谢蟪旭
Owner HENAN UNIV OF SCI & TECH
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