Preparation method of small-size abalone shell hydroxyapatite porous microspheres

A technology of shell hydroxyapatite and hydroxyapatite, which is applied in the field of preparation of small-sized abalone shell hydroxyapatite, can solve the problems of resource waste, environmental pollution, etc., achieve low cost, simple preparation method, and improve injectability sexual effect

Active Publication Date: 2019-09-17
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the waste of resources and environmental pollution caused by discarding the empty shells of shellfish aquatic products after proces

Method used

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  • Preparation method of small-size abalone shell hydroxyapatite porous microspheres
  • Preparation method of small-size abalone shell hydroxyapatite porous microspheres
  • Preparation method of small-size abalone shell hydroxyapatite porous microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1) Soak the abalone shell in acetic acid solution with a volume fraction of 30% for 6 hours, remove the surface material, rinse it with deionized water, and let it dry naturally;

[0039] 2) Crushing and grinding the air-dried abalone shell, and screening with a 200-mesh filter to obtain abalone shell powder;

[0040] 3) Take 0.5g of abalone shell powder, dissolve it in acetic acid solution with a volume fraction of 10%, and centrifuge to obtain the supernatant after stirring continuously until no bubbles are generated. The centrifugation speed is 9000rpm, the time is 5min, and the temperature is 4°C;

[0041] 4) Dilute the supernatant to 50ml, transfer it to a 100ml beaker, and add phosphoric acid solution (50ml, 0.06M) dropwise at a rate of 1ml / min (guarantee that the Ca / P molar ratio is n(Ca 2+ ):n(PO 4 3- )=1.67:1), the whole process continued to stir.

[0042] 5) After the phosphoric acid solution is added dropwise, add 0.2352g sodium citrate, 1.25g polyaspartic...

Embodiment 2

[0047] 1) Soak the abalone shell in acetic acid solution with a volume fraction of 20% for 6 hours, remove the surface layer, rinse with deionized water, and let it dry naturally;

[0048] 2) Crushing and grinding the air-dried abalone shell, and screening with a 200-mesh filter to obtain abalone shell powder;

[0049] 3) Take 0.5g of abalone shell powder, dissolve it in acetic acid solution with a volume fraction of 20%, and centrifuge to obtain the supernatant after stirring continuously until no bubbles are generated. The centrifugation speed is 9000rpm, the time is 5min, and the temperature is 4°C;

[0050] 4) Dilute the supernatant to 50ml, transfer it to a 100ml beaker, and add phosphoric acid solution (50ml, 0.06M) dropwise at a rate of 1ml / min (guarantee that the Ca / P molar ratio is n(Ca 2+ ):n(PO 4 3- )=1.67:1), the whole process continued to stir.

[0051] 5) After the phosphoric acid solution is added dropwise, add 2.3528g of sodium citrate, 6g of polyaspartic ac...

Embodiment 3

[0056] 1) Soak the abalone shell in acetic acid solution with a volume fraction of 10% for 6 hours, remove the surface material, rinse it with deionized water, and let it dry naturally;

[0057] 2) Crushing and grinding the air-dried abalone shell, and screening with a 200-mesh filter to obtain abalone shell powder;

[0058] 3) Take 0.5g of abalone shell powder, dissolve it in acetic acid solution with a volume fraction of 10%, and centrifuge to obtain the supernatant after stirring continuously until no bubbles are generated. The centrifugation speed is 9000rpm, the time is 5min, and the temperature is 4°C;

[0059] 4) Dilute the supernatant to 50ml, transfer it to a 100ml beaker, and add phosphoric acid solution (50ml, 0.06M) dropwise at a rate of 1ml / min (guarantee that the Ca / P molar ratio is n(Ca 2+ ):n(PO 4 3- )=1.67:1), the whole process continued to stir.

[0060] 5) After the phosphoric acid solution is added dropwise, add 0.2352g sodium citrate, 5g polyaspartic ac...

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Abstract

The invention discloses a preparation method of small-size abalone shell hydroxyapatite porous microspheres. The preparation method comprises the following steps: taking abalone shells as a main raw material, cleaning substances on the surface layers of the abalone shells, conducting naturally drying, crushing and sieving the substances by 200 meshes to obtain abalone shell powder, dissolving abalone shell powder, and then dripping a phosphoric acid solution at a constant speed according to the molar ratio of Ca to P of 1.67 to 1, then adding sodium citrate and a poly aspartic acid template agent, simultaneously adding urea to adjust the pH, and synthesizing uniformly stirred precursor reaction solution into the hydroxyapatite porous microspheres by a hydrothermal method. The preparation method is simple, wide in raw material source, low in cost and easy to popularize.

Description

technical field [0001] The invention belongs to the field of material preparation, and in particular relates to a method for preparing small-sized abalone shell hydroxyapatite. Background technique [0002] With the improvement of people's economic income and living standards and the gradual decline of abalone prices, people's demand for abalone is increasing, which greatly drives the development of abalone aquaculture. Since the 1990s, my country's abalone farming industry has developed rapidly. In 2010, the abalone farming volume in my country was 56,500 tons, which increased rapidly to 148,500 tons in 2017, accounting for 86% of the world's total abalone farming production. In the same year, my country's abalone export volume was about 30 times that of my country's abalone production 30 years ago. Fujian Province is a large aquatic province, rich in shellfish. Lianjiang County is located in the eastern coast of Fujian Province. It has a mid-subtropical climate. The clim...

Claims

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Application Information

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IPC IPC(8): C01B25/32A61K47/02A61K9/00A61P35/00
CPCC01B25/325A61K47/02A61K9/0019A61P35/00C01P2002/72C01P2004/03C01P2004/61C01P2006/16C01P2006/17C01P2004/32Y02A40/81
Inventor 陈景帝黄浩杜明足邢化冉
Owner SHANDONG UNIV
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