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Phosphorylcholine structure-modified graphene oxide and preparation method thereof

A phosphorylcholine and graphene technology is applied in the field of graphene oxide modified by phosphorylcholine structure and its preparation, which can solve problems such as application limitation and poor dispersibility, and achieve stable dispersibility, good dispersibility, and a preparation process. easy effect

Inactive Publication Date: 2012-09-19
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Graphene oxide (Graphene Oxide, GO) is a quasi-two-dimensional solid with a layered structure. Because it contains many polar groups such as -COOH, -OH, epoxy groups, etc., it can be obtained in pure water Good dispersion, but poor dispersion in salt solution and cell culture fluid, which limits its application in the biomedical field. In order to change this situation, graphite oxide needs to be further modified

Method used

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  • Phosphorylcholine structure-modified graphene oxide and preparation method thereof
  • Phosphorylcholine structure-modified graphene oxide and preparation method thereof
  • Phosphorylcholine structure-modified graphene oxide and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] (1) Activation pretreatment of graphene oxide: Take 2 g of graphene oxide and place it in a flask, add 100 mL of cerium ammonium nitrate (20 mmol / L) in nitric acid (0.14 mol / L) solution, and continuously Use an ultrasonic cleaner (power 50W) to perform ultrasonic treatment for 5 hours and then centrifuge, pour off the upper acid solution, add 250mL of distilled water, continue ultrasonic dispersion and centrifuge, pour off the supernatant, and repeat this process until the pH of the supernatant is neutral. After inactivation, the activated graphene oxide dispersion (GO) was obtained;

[0035] (2) Grafting of activated graphene oxide and phosphorylcholine structure: add an aqueous solution containing 1g of methacryloyloxyethyl phosphorylcholine to the obtained activated graphene oxide dispersion, and , stirred and reacted at 90°C for 5 hours, the reaction mixture was repeatedly washed with pure water and centrifuged to remove unreacted methacryloyloxyethylphosphorylcholi...

Embodiment 2

[0037] The other steps are the same as in Example 1, except that the centrifugal purification in step (1) is replaced by semipermeable membrane dialysis to obtain graphene oxide grafted with phosphorylcholine.

Embodiment 3

[0039] The other steps are the same as in Example 1, except that the nitric acid solution of ammonium cerium nitrate in step (1) is replaced with 300 mL of potassium permanganate (40 mmol / L) solution, and ultrasonically reacted at 80 ° C for 3 hours to obtain grafted phosphoryl Graphene oxide of choline.

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Abstract

The invention discloses phosphorylcholine structure-modified graphene oxide and a preparation method thereof. The phosphorylcholine structure-modified graphene oxide is formed by connecting at least one oligomer containing a phosphorylcholine structure to a graphene oxide slice by a chemical grafting mode. The phosphorylcholine structure-modified graphene oxide is chemically grafted with the hydrophilic phosphorylcholine structure, so that the phosphorylcholine structure-modified graphene oxide is high in dispersibility and stable in water, saline and cell culture fluid, and can be placed at room temperature for a long term and does not have precipitate. The phosphorylcholine structure is an inherent compound such as a part of phospholipid in an organism, so that the phosphorylcholine structure-modified graphene oxide possibly has biocompatibility and is possibly applied to the biomedical field. The preparation method for the phosphorylcholine structure modified graphene oxide is simple, convenient and reliable and is easy to implement.

Description

technical field [0001] The invention relates to a method of chemical grafting to modify the hydrophilic structure on graphene oxide to obtain graphene oxide with good dispersibility and a preparation method thereof, in particular to a graphene oxide modified by phosphorylcholine structure The preparation method thereof belongs to the field of nanotechnology. Background technique [0002] In 2004, British scientists discovered a new type of two-dimensional atomic crystal graphene (Graphene) composed of single atomic layers of carbon atoms connected by sp2 hybridization. Its basic structural unit is the most stable benzene six-membered ring in organic materials, and it is currently the most ideal two-dimensional nanomaterial. Perfect graphene has an ideal two-dimensional crystal structure, which is composed of hexagonal lattice. From the structural point of view, the carbon-based two-dimensional crystal of graphene is the basic unit for forming sp2 hybridized carbonaceous mat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B31/04C01B32/198
Inventor 张弢刘愚蒋正生
Owner NANJING UNIV
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