Method for synthesizing fluorine halogenated ether

Abstract

The invention discloses a method for synthesizing fluorine halogenated ether. The method comprises the following steps of: 1) adding ethylene glycol, solvent and catalyst into a reaction kettle, introducing tetrafluoroethylene with stirring and starting to react, wherein the mass ratio of tetrafluoroethylene to ethylene glycol is 1:(2-8), the mass ratio of the solvent to the ethylene glycol is (0.25-4.5):1, the mass ratio of the catalyst to the ethylene glycol is 1:(5-27), controlling reaction temperature to be 10 to 125 DEG C and reaction pressure to be 0.1 to 1.5MPa, stopping introducing tetrafluoroethylene, then cooling, discharging, and rectifying to obtain 2-(1,1,2,2-tetrafluoroethoxy) ethanol; and 2) reacting the 2-(1,1,2,2-tetrafluoroethoxy) ethanol which is obtained in the step 1) and a halogenating agent in a mass ratio of 1:(0.5-2) at the temperature of between 50 and 100 DEG C for 1 to 5 hours, cooling a reaction solution, washing, layering, and rectifying to obtain a product. The method is mild in reaction condition, low in cost, and in yield; and the product is high in quality.

Description

technical field [0001] The invention relates to a method for synthesizing fluorohalogenated ethers. Background technique [0002] Fluorohalogenated ethers, especially fluorohalogenated ethers whose end groups are substituted by halogen atoms, not only have the active groups of the end groups, but also have the advantages of low surface tension and high stability of fluorine-containing chemicals, and play an important role in organic synthesis. The important role is an important medicine, pesticide intermediate and substitute Freon compound. Because fluorohalogenated ethers whose end groups are substituted by halogen atoms are widely used in organic chemical and pharmaceutical synthesis, a lot of research has been done on their synthesis at home and abroad, but there are few literature reports. The synthesis method is as follows: [0003] For example, Chinese Patent Publication No. CN1660740A, date of publication August 31, 2005, title of invention: method for preparing fluo...

AI Technical Summary

Problems solved by technology

The disadvantage is that the reaction principle perfluoropolyether diacyl fluoride is difficult to obtain and expensive; the reaction needs to be carried out at a very low temperature, the reaction time is long, and the reaction conditions are harsh; the product selectivity is low

The disadvantage is that the reaction raw material sulfuryl fluoride (SO2F2) has a boiling point of -49.7°C, which is difficult to store and is not easy to obtain; the reaction is carried out at a low temperature of -78°C, and the reaction time is within 72 hours. The reaction conditions are harsh and the energy consumption is large; When the reaction temperature is above the boiling point of sulfuryl fluoride (SO2F2), it needs to be carried out in a pressure vessel

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