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Application of sugar-containing platinum complex in preparation of medicines for preventing and treating tumor

A platinum complex, tumor drug technology, applied in antitumor drugs, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of strong toxic and side effects, difficult renal elimination, long retention time

Inactive Publication Date: 2012-10-10
TIANJIN GUDUI BIOLOGICAL MEDICAL TECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, as mentioned above, platinum-based antitumor drugs developed so far, such as cisplatin, carboplatin, and oxaliplatin, all have the characteristics of extremely strong toxic and side effects and extremely low water solubility.
The long residence time of the low water solubility platinum drugs developed so far in the blood and the difficulty of being excreted by the kidneys are the main factors leading to the nephrotoxic side effects of these drugs

Method used

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  • Application of sugar-containing platinum complex in preparation of medicines for preventing and treating tumor
  • Application of sugar-containing platinum complex in preparation of medicines for preventing and treating tumor
  • Application of sugar-containing platinum complex in preparation of medicines for preventing and treating tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: Inhibitory effect of sugar-containing platinum complexes on cancer cell proliferation

[0076] The following experiments were conducted to verify the inhibitory effect of the sugar-containing platinum complex on the proliferation of different types of human tumor cells.

[0077] (1) Test method:

[0078] Cell Culture Medium:

[0079] A cell culture solution containing 10% fetal bovine serum, 1 mM sodium pyruvate, 2 mM-glutamine, 50 U / ml penicillin, and 50 μg / ml streptomycin was used.

[0080] Main experimental instruments: MCO-15A carbon dioxide incubator (SANYO, Japan), inverted phase contrast microscope (Olympus, Japan), automatic microplate reader (BioTEK ELX808, USA), low-temperature refrigerator (MDF-V5410, Japan), ultra-clean bench (Suzhou Medical Device Factory), micropipette (GILSON, France), automatic pure water distiller (Shanghai 1810B).

[0081] Experimental reagents:

[0082] MTS: CellTiter96 Aqueous MTS Reagent Powder, Promega

[0083] PMS:...

Embodiment 2

[0104] Example 2: Inhibitory effect on human cancer cell proliferation when the platinum complex containing sugar is combined with other chemotherapeutic drugs (active components)

[0105] The following experiment studies the enhanced or synergistic effect on the proliferation inhibition of different types of human tumor cells when the glycoplatinum complex is combined with other chemotherapeutic drugs (active components).

[0106] (1) Test method:

[0107] Cell Culture Medium:

[0108] A cell culture medium containing 10% fetal bovine serum, 1 mM sodium pyruvate, 2 mM L-glutamine, 50 U / ml penicillin, and 50 μg / ml streptomycin was used.

[0109] Main experimental instruments: MCO-15A carbon dioxide incubator (SANYO, Japan), inverted phase contrast microscope (Olympus, Japan), automatic microplate reader (BioTEK ELX808, USA), low-temperature refrigerator (MDF-V5410, Japan), ultra-clean bench (Suzhou Medical Device Factory), micropipette (GILSON, France), automatic pure water ...

experiment example 3

[0149] In the following experiments, 8-9-week-old female CDF1 mice were used, with an average weight of 20-25 grams. The experimental animals were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. With L1210 tumor cells (10 5 cells per mouse) were inoculated intraperitoneally. For the tumor animal model made, use platinum complexes containing sugar for treatment, and compare with platinum anti-tumor drugs used in clinical practice, verify the therapeutic effect of platinum complexes containing sugar on tumor animals and the effect of platinum complexes containing sugar on experimental animals. toxic side effects. For the sugar-containing platinum complex and carboplatin, a 5% mannitol aqueous solution was used, and for cisplatin, a 5% mannitol saline solution was used to prepare the corresponding injection. Drugs were injected intraperitoneally on the 1st and 4th days after tumor cell transplantation, and the number of experimental animals in each...

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Abstract

The invention discloses application of a sugar-containing platinum complex in the preparation of medicines for preventing and treating tumor. The sugar-containing platinum complex is shown as the formula (I). The test proves that the sugar-containing platinum complex shown as the formula (I) can prevent and treat cancer of mammals, such as lung cancer, colon cancer, head and neck cancer, prostatic cancer, breast cancer, ovarian cancer, cervical cancer, leukemia, lymphoma, skin cancer, pancreatic cancer, liver cancer, bladder cancer, esophageal cancer, stomach cancer, male genital organ cancer, bone cancer and the like of the mammals, in particular can prevent and treat lung cancer, colon cancer, head and neck cancer, prostatic cancer, breast cancer, ovarian cancer, cervical cancer, leukemia, lymphoma, skin cancer, pancreatic cancer, liver cancer, bladder cancer, esophageal cancer, stomach cancer, male genital organ cancer or bone cancer of human beings.

Description

technical field [0001] The invention relates to the use of a drug for preventing and treating tumors, in particular to the use of a sugar-containing platinum complex in the preparation of drugs for preventing and treating tumors. Background technique [0002] Cancer is a disease in which the DNA of cells mutates suddenly under certain conditions, resulting in uncontrolled cell division, resulting in continuous proliferation and metastasis, which eventually leads to the death of the host. Drugs for the treatment of cancer are mainly divided into cell DNA alkylating agents, cell metabolism antagonists, antitumor antibiotics, plant alkaloids, metal platinum complexes, asparaginase preparations and hormone therapy agents. Almost all antitumor drugs aim to effectively prevent rapid cell division in a short period of time, so it is often difficult to achieve the purpose of killing cancer cells with high selectivity in distinguishing normal cells from tumor cells. [0003] Platinu...

Claims

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Application Information

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IPC IPC(8): A61K31/7135A61P35/00A61P35/02
Inventor 王以强刘阳
Owner TIANJIN GUDUI BIOLOGICAL MEDICAL TECH INC
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