Lansoprazole enteric oral disintegrating tablet and preparation method thereof

A technology of lansoprazole enteric and lansoprazole, which is applied in the field of nanometerized enteric-coated orally disintegrating tablet preparations, can solve the problems of unfavorable patient pain, low bioavailability, and dysphagia, and achieve easy swallowing, reduced stimulation, Good for absorption

Inactive Publication Date: 2012-12-05
双鹤药业(海南)有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary enteric-coated tablets can prevent the degradation of the drug, but the disintegration is slow and the bioavailability is low, which is not conducive to timely relief of the pain of the patient; some patients have difficulty swallowing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Lansoprazole 20.0g

[0028] soybean oil 20g

[0029] Acrylic resin 30g

[0030] Poloxamer 10g

[0031] Cross-linked polyvinylpyrrolidone 40g

[0032] Magnesium Stearate 9g

[0033] Citric acid 1.2g

[0034] Made in 1000 pieces.

[0035] 30 g of acrylic resin and 270 g of ethanol are formulated into a capsule material solution, 20 g of soybean oil and 20 g of nano-sized lansoprazole are added, and stirred for 0.5 h. Slowly add the above solution to 5 times the volume (1500ml) of an aqueous solution containing 0.1% (1.5ml) poloxamer while stirring, stir for 1 hour, pass through a microporous membrane, stand and separate layers; the precipitate is dried to obtain blue Soprazole enteric-coated nanocapsules; mix the nanocapsules with the prescribed amount of PVPP, magnesium stearate, and citric acid, and press them into tablets, each weighing about 0.12g.

Embodiment 2

[0037] Lansoprazole 20.0g

[0038] Palm oil 25g

[0039] Acrylic resin 30g

[0040] Poloxamer 10g

[0041] Microcrystalline Cellulose 30g

[0042] Magnesium Stearate 9g

[0043] Aspartame 1.0g

[0044] Made in 1000 pieces.

[0045] Mix 30g of acrylic resin with 270g of ethanol to form a capsule material solution, add 35g of palm oil and 20g of nano-sized lansoprazole, and stir for 1 hour. Slowly add the above solution to 10 times the volume (3000ml) of an aqueous solution containing 0.5% (15ml) poloxamer while stirring, stir for 2 hours, pass through a microporous membrane, stand and separate layers; the precipitate is dried to obtain Lanso Prazole enteric-coated nanocapsules; the nanocapsules are mixed with the prescribed amount of microcrystalline cellulose, magnesium stearate and aspartame, and pressed into tablets, each weighing about 0.12g.

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Abstract

The invention relates to a nanometer lansoprazole enteric oral disintegrating tablet and a preparation method thereof. The lansoprazole enteric oral disintegrating tablet contains about 10-90 percent by weight of a nanocapsule. The lansoprazole enteric oral disintegrating tablet provided by the invention is not required to be taken with water, and can be used for quickly disintegrating an enteric nanocapsule in an oral cavity; the particle diameter of the nanocapsule is less than 1,000 nanometers, and does not cause sand feel in mouth; and compared with an ordinary enteric tablet or enteric capsule, the nanometer lansoprazole enteric oral disintegrating tablet has the characteristics of good treatment effect, high repeatability, high adaptability and the like, is suitable for patients suffering from mental diseases or dysphagia caused by peptic ulcer, and contributes to bringing greater flexibility to clinical administration.

Description

technical field [0001] The invention relates to an oral solid preparation for treating gastric ulcer, duodenal ulcer, reflux esophagitis, Zollinger-Ellison syndrome and anastomotic ulcer, in particular to a preparation with lansoprazole as an active ingredient Nanosized enteric-coated orally disintegrating tablet preparation. Background technique [0002] Peptic ulcer mainly refers to chronic ulcers that occur in the stomach and duodenum. It is a frequently-occurring disease and a common disease. There are various factors in the formation of ulcers, among which the digestion of mucous membrane by acidic gastric juice is the basic factor in the formation of ulcers. Any site in contact with acidic gastric juice, such as the lower esophagus, anastomosis after gastrointestinal anastomosis, jejunum, and Meckel's diverticulum with ectopic gastric mucosa. The vast majority of ulcers occur in the duodenum and stomach, so they are also called gastric and duodenal ulcers. [0003] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/51A61K31/4439A61P1/04
Inventor 魏雪纹李强
Owner 双鹤药业(海南)有限责任公司
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