Oil-in-water type sotalol and eucommia seed oil nanoemulsion antihypertensive drug
A technology of Eucommia ulmoides seed oil and anti-hypertension, applied in the field of medicine, can solve the problems such as the inability to fully utilize the efficacy of sotalol and eucommia seed oil, slow action of sotalol, slow drug dissolution rate, etc. Blood concentration and pharmacological effects, reducing first-pass effect and improving bioavailability
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Embodiment 1
[0055] Accurately weigh 8.2g of Eucommia ulmoides seed oil, 28g of EL40 and 4g of ethanol and stir evenly at room temperature (25°C), then slowly drop distilled water in which sotalol is dissolved. As the amount of distilled water increases, the viscosity of the system increases. When the amount of distilled water is added to make the system change from water-in-oil to oil-in-water nanoemulsion, the viscosity of the system becomes thinner from the most viscous state. What is colorless and transparent sotalol, eucommia seed oil nanoemulsion, the amount of adding water at this moment is 53.7g, and sotalol is 6.1g. This ratio is the optimal ratio of sotalol and eucommia seed oil antihypertensive nanoemulsion.
[0056] Following embodiment steps are with embodiment 1:
Embodiment 2
[0058] Eucommia ulmoides seed oil 7.5g, EL40 26g, 1,2-propanediol 12g, water 48.5g, sotalol 6g.
Embodiment 3
[0060] Eucommia ulmoides seed oil 9.5g, RH40 25g, glycerol 18g, water 44g, sotalol 3.5g.
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