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Hard template hydroxyapatite powder morphology hydrothermal controlling method

A technology of hydroxyapatite and hard template, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve problems such as environmental and human health hazards

Inactive Publication Date: 2012-12-19
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It can be seen that in these methods, a large amount of toxic templates, organic solvents, and surfactants are widely used, and these reagents are very harmful to the environment and human health.

Method used

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  • Hard template hydroxyapatite powder morphology hydrothermal controlling method
  • Hard template hydroxyapatite powder morphology hydrothermal controlling method
  • Hard template hydroxyapatite powder morphology hydrothermal controlling method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Prepare 0.25mol / L calcium chloride (CaCl 2 ) and sodium carbonate (Na 2 CO 3) aqueous solution. An equal volume of aqueous sodium carbonate was added dropwise to aqueous calcium chloride with vigorous stirring. After the dropwise addition was complete, stirring was continued for 2 hours. Afterwards, filter, wash and dry to obtain calcium carbonate powder. The X-ray diffraction pattern shows that the product is composed of calcite phase (calcite) and vaterite phase (vaterite) (such as figure 1 A), scanning electron microscopy results show that the morphology of the product is nanoparticle (such as image 3 A).

[0029] The calcium carbonate powder 1g that prepares is the Na that 85mL concentration is 0.2mol / L 3 PO 4 Mix the aqueous solution (the molar ratio of calcium to phosphorus is about 0.6), transfer to a 100mL reactor after mixing, and conduct hydrothermal treatment at 180°C for 72 hours. After the hydrothermal reaction, filter and wash to obtain the produ...

Embodiment 2

[0031] Prepare 0.5mol / L calcium nitrate (Ca(NO 3 ) 2 ) and sodium silicate (Na 2 SiO 3 ) aqueous solution. An equal volume of calcium nitrate aqueous solution was added dropwise to the sodium silicate aqueous solution with stirring. After the dropwise addition was completed, the reactant was put into the reaction kettle, and hydrothermally treated at 200° C. for 24 hours. After that, filter, wash and dry to obtain calcium silicate hydrate powder. The X-ray diffraction pattern shows that the product is a xonotlite phase (xonotlite) composition (such as figure 1 B), scanning electron microscopy results show that the morphology of the product is a well-dispersed nanowire with a diameter of about 20 nanometers and a length of up to 2 microns (such as image 3 C).

[0032] 1 gram of the prepared xonotlite powder was mixed with 85 mL of Na with a concentration of 0.2 mol / L 3 PO 4 Mix the aqueous solution (the molar ratio of calcium to phosphorus is about 0.5), transfer to a...

Embodiment 3

[0034] Under vigorous stirring, quickly mix the same volume of 0.2mol / L calcium chloride solution and 0.1mol / L sodium lauryl sulfate solution, continue vigorous stirring and add 0.2mol / L carbonic acid equal to the volume of the mixed solution sodium solution. Stirring was continued for 30 minutes after mixing. Afterwards, filter, wash and dry to obtain calcium carbonate hollow microspheres. X-ray diffraction patterns show that the product is composed of calcite (calcite) phase (such as figure 1 C), scanning electron microscopy results show that the morphology of the product is a monodisperse hollow microsphere, and the diameter of the ball is about 2-3 microns (such as image 3 E).

[0035] 1 gram of calcium carbonate hollow microspheres prepared with 85mL concentration is 0.2mol / L Na 3 PO 4 Mix the aqueous solution (the molar ratio of calcium to phosphorus is about 0.6), transfer to a 100mL reactor after mixing, and conduct hydrothermal treatment at 180°C for 72 hours. ...

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Abstract

The invention relates to a hard template hydroxyapatite powder morphology hydrothermal controlling method, and belongs to the field of biomedical materials. According to the invention, crystalline-state calcium carbonate with a specific morphology or crystalline-state calcium silicate hydrate (CSH) is adopted as a hard template raw material. The hard template raw material is mixed with a soluble phosphate aqueous solution with a concentration of 0.05-2.5mol / L according to a calcium-phosphorus molar ratio of 0.01-2.0, and the mixture is subjected to a hydrothermal reaction. After the reaction, the morphology of the adopted hard template raw material is maintained well, and the morphology of the obtained hydroxyapatite is consistent with that of the hard template raw material. The preparation method provided by the invention has the advantages of simple and feasible technologies, low cost, environment-friendly technology, easy popularization, and the like. Prepared hydroxyapatite powder with various morphologies can be applied in respects of hard tissue repairing materials, chromatographic separation reagents, drugs and catalytic carriers, polymer mechanical reinforcement materials, and the like.

Description

technical field [0001] The invention relates to a method for hydrothermally controlling the morphology of hydroxyapatite powder with a hard template, which belongs to the field of biomedical materials. Background technique [0002] Hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 , HAp] are widely used in biomedical materials, chemical engineering, gas sensors, catalysts, and environmental engineering and other fields. These application fields of HAp depend to a large extent on the morphology of the material. For example, HAp nanoparticles with good dispersion can be used for gene transfection (Biomaterials, 2007, 28, 1267.), rod-shaped or linear HAp has good mechanical properties, and can be used to enhance the mechanical reinforcement components of composite biomaterials (J .Am.Ceram.Soc.2007, 90, 3694.; Nature 2004, 431, 287.; Mater.Sci.Eng.C 2009, 29, 2133.), the hollow nanostructure HAp has good drug or protein adsorption and The controlled release performance can be used a...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y40/00
Inventor 常江林开利金晓刚
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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