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Paracetamol vitamin C effervescent tablet and preparation process thereof

A technology of paracetamol and preparation process, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems such as reducing the production efficiency of effervescent tablets, and achieve the Good, rapid disintegration, high production efficiency

Active Publication Date: 2012-12-26
SHENYANG ORIGINAL PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many factors that affect the disintegration of effervescent tablets, such as high viscosity, which is not conducive to the penetration of water into the tablet core, etc.
[0008]Poor solubility: The effervescent tablets on the market do not dissolve satisfactorily, the solution is not clear and transparent, and the taste is not good
[0009] Stickiness: The biggest problem in the production of effervescent tablets is stickiness, especially when preparing effervescent extract tablets, which seriously reduces the effervescence Chip production efficiency

Method used

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  • Paracetamol vitamin C effervescent tablet and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Crushing and sieving: use TF-260 turbo self-cooling pulverizer and XZS-400 vortex vibration sieving machine to take 9.5kg of mannitol, 2.375kg of glycine, and 42.75kg of citric acid under an 80-mesh sieve. Crush and sieve. Material balance: 99.95-100.00%.

[0032] (2) Mixing: Use GH-500 three-dimensional motion mixer to pre-mix 9.5kg of vitamin C, glycine, 15.675kg of acetaminophen, mannitol, citric acid, and 61.75kg of sodium bicarbonate at a speed of 900r / min , mixed for 30min. The mixed material is compressed into large pieces by a tablet press, and granulated by a YK-160A swinging granulator through a 16-mesh sieve. Finally, the dry granules and 2.375 kg of sodium lauryl sulfate were mixed in a three-dimensional motion mixer at a speed of 600 r / min, and mixed for 10 minutes. Yield: ≮99.00% Material balance: 99.80-100.00%.

[0033] (3) Tablet compression: pass the mixed material through a ZPY-27B rotary tablet press machine, and press it with a Φ23mm fl...

Embodiment 2

[0035] (1) Crushing and sieving: use TF-260 turbo self-cooling pulverizer and XZS-400 vortex vibration sieving machine, take 10kg of mannitol, 2.5kg of glycine, and 45kg of citric acid to pulverize under a 80-mesh sieve. sieve. Material balance: 99.95-100.00%.

[0036] (2) Mixing: Use GH-500 three-dimensional motion mixer to pre-mix 10kg of vitamin C, glycine, 16.5kg of acetaminophen, mannitol, citric acid, and 65kg of sodium bicarbonate at a speed of 900r / min for 30min. . The mixed material is compressed into large pieces by a tablet press, and granulated by a YK-160A swinging granulator through a 16-mesh sieve. Finally, the dry granules and 2.5 kg of sodium lauryl sulfate were mixed in a three-dimensional motion mixer at a speed of 600 r / min for 10 minutes. Yield: ≮99.00% Material balance: 99.80-100.00%.

[0037] (3) Tablet compression: pass the mixed material through a ZPY-27B rotary tablet press machine, and press it with a Φ23mm flat punch. The room temperature ...

Embodiment 3

[0039] (1) Crushing and sieving: use TF-260 turbo self-cooling pulverizer and XZS-400 vortex vibrating sieving machine to take 10.5kg of mannitol, 2.625kg of glycine, and 47.25kg of citric acid under a 80-mesh sieve. Crush and sieve. Material balance: 99.95-100.00%.

[0040] (2) Mixing: Use GH-500 three-dimensional motion mixer to pre-mix 10.5kg of vitamin C, glycine, 17.325kg of acetaminophen, mannitol, citric acid, and 68.25kg of sodium bicarbonate at a speed of 900r / min , mixed for 30min. The mixed material is compressed into large pieces by a tablet press, and granulated by a YK-160A swinging granulator through a 16-mesh sieve. Finally, the dry granules and 2.625 kg of sodium lauryl sulfate were mixed in a three-dimensional motion mixer at a speed of 600 r / min for 10 minutes. Yield: ≮99.00% Material balance: 99.80-100.00%.

[0041] (3) Tablet compression: pass the mixed material through a ZPY-27B rotary tablet press machine, and press it with a Φ23mm flat punch. ...

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Abstract

The invention provides a paracetamol vitamin C effervescent tablet and a preparation process thereof, belongs to the technical field of pharmaceutic preparations, and particularly relates to the paracetamol vitamin C effervescent tablet and the preparation process thereof. The invention provides the paracetamol vitamin C effervescent tablet which is rapidly disintegrated, can be effectively dissolved, is not sticky during the tabletting and has a good tablet shape, and the preparation process thereof. Tablet cores of 50, 000 paracetamol vitamin C effervescent tablets provided by the invention comprise following components by weight ratio: 15.675kg to 17.325kg of paracetamol, 9.5kg to 10.5kg of vitamin C, 2.375kg to 2.625kg of glycine, 9.5kg to 10.5kg of mannitol, 42.75kg to 47.25kg of citric acid, 61.75kg to 68.25kg of sodium bicarbonate and 2.375kg to 2.625kg of sodium dodecyl sulfate.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a paracetamol vitamin C effervescent tablet and a preparation process thereof. Background technique [0002] Acetaminophen, usually a white crystalline powder, is obtained by reducing sodium p-nitrophenolate to p-aminophenol and then acylation. It is the most commonly used non-steroidal anti-inflammatory antipyretic and analgesic drug. Its antipyretic effect is similar to that of aspirin. It is the best variety among acetanilide drugs, especially suitable for patients who cannot use carboxylic acid drugs. In addition, it is used for joint pain, neuralgia, migraine, cancer pain and pain relief after surgery. [0003] Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin. It plays an important regulatory role in redox metabolism, lack of it will cause scurvy; in addition, it can promote the synthesis of collagen, which is beneficial ...

Claims

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Application Information

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IPC IPC(8): A61K9/46A61K31/375A61K47/18A61P29/00A61K31/167
Inventor 魏国平韦松
Owner SHENYANG ORIGINAL PHARMACY
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