Method for in-situ detecting of drug molecules in animal tissues by dual-beam laser mass-spectrography
A technology for in-situ detection of drug molecules, applied in measuring devices, analyzing materials, and analyzing materials through electromagnetic means, can solve problems such as inability to detect, and achieve the effects of improved applicability, simple operation, and short pretreatment time
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Embodiment 1
[0035] Embodiment 1: A kind of dual-beam laser mass spectrometer
[0036]The double-beam laser mass spectrometer comprises a digital delay generator 7, a sampling system 1, solid-state lasers 2 and 9, a vacuum system, a gas cell 5, a plano-convex mirror, a data acquisition device 6 and a data processing device 12; the vacuum system includes Ionization chamber 10, flight tube 3 and microchannel plate 4, one end of flight tube 3 is connected with ionization chamber 10, and the other end is provided with microchannel plate 4; Described solid-state laser is two, is placed next to the vacuum system respectively, solid-state laser 2 A B prism 11 is set between the ionization chamber 10, a gas cell 5 is set between the solid-state laser 9 and the ionization chamber 10, an A prism 8 is set between the solid-state laser 9 and the gas cell 5, and the side of the gas cell 5 close to the ionization chamber 10 A plano-convex mirror is set; the data acquisition device 6 is an oscilloscope, ...
Embodiment 2
[0037] Example 2: Using the dual-beam laser mass spectrometer described in Example 1, the detection of the photodynamic therapy drug molecule methylene blue in cancer tissue by dual-beam laser mass spectrometry.
[0038] The steps of L2MS detection of methylene blue in cancer tissue are as follows ( figure 1 ):
[0039] (1) Use ethanol as a test molecule to detect the performance of the entire mass spectrometry system
[0040] As a conventional laboratory reagent, ethanol has a low saturated vapor pressure. It can be cooled by combining ultrasonic molecular beam with helium as the carrier gas. The helium pressure is 0.1Mpa, and the vacuum degree of the molecular beam is 5.0×10 -3 Pa, and then ionize it with a vacuum ultraviolet laser, that is, a 118nm ionization laser, and the vacuum degree of the ionization chamber is 1.0×10 -5 Pa, where the delay time between the molecular beam and the ionizing light is 80μs, a relatively standard spectrum can be obtained to test the stabi...
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