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Sodium chloride eye drops and preparation method thereof

An eye drop, sodium chloride technology, applied in the direction of alkaline/alkaline earth metal chloride active ingredients, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problem of short duration, increased permeability, and corneal permeability. Increase in sex and other issues, to achieve the effect of stable quality and replenishment of water

Active Publication Date: 2014-09-10
KANGYA OF NINGXIA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of most artificial tears on the treatment of dry eye is unstable, and the duration is short, and domestically contains more antibacterial agents and other auxiliary materials, which have a certain toxic effect on the ocular surface epithelium
At present, most of the antibacterial agents for commercially available eye drops are benzalkonium chloride, which can destroy the tight junction zone between corneal epithelial cells, increase the permeability of the cornea, and can also combine with the lipid membrane of the corneal epithelial cell membrane to make the cell membrane Increased permeability to water and various ions reduces the efficacy of artificial tears
[0005] In recent years, although there are eye drops that can increase the moisturizing effect on the market, such as sodium hyaluronate eye drops or eye drops containing sodium hyaluronate, sodium hyaluronate is unstable under light and heat and is easy to degrade. It is not suitable for long-term storage at room temperature. At the same time, sodium hyaluronate is a kind of biological macromolecule mucopolysaccharide, which is easy to be polluted and grow bacteria

Method used

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  • Sodium chloride eye drops and preparation method thereof
  • Sodium chloride eye drops and preparation method thereof
  • Sodium chloride eye drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Based on 100ml, the prepared eye drops contain:

[0030] Sodium chloride 0.55g, hypromellose 0.03g, boric acid 0.53g, borax 0.05g, ethylparaben 0.03g, water for injection.

[0031] The preparation method comprises the following steps:

[0032] (1) Take 0.05g hypromellose in advance and add it to an appropriate amount of water for injection, dissolve it for later use.

[0033] (2) Take by weighing 0.55g of sodium chloride, 0.03g of ethylparaben, 0.53g of boric acid and 0.05g of borax respectively, add appropriate amount of water for injection respectively, stir and put into a triangular beaker after mixing evenly and put it into an autoclave (121 ℃, 30 minutes) for sterilization.

[0034] (3) Heat and dissolve the sterilized ethylparaben with an appropriate amount of water for injection.

[0035] (4) Add the above-mentioned sterilized sodium chloride, boric acid, and borax into the ethylparaben solution placed at room temperature in the above-mentioned (3), stir to di...

Embodiment 2

[0039] Based on 100ml, the prepared eye drops contain:

[0040] Sodium chloride 0.55g, hypromellose 0.05g, boric acid 0.53g, borax 0.05g, ethylparaben 0.03g, water for injection.

[0041] Its preparation method is with above-mentioned embodiment 1.

Embodiment 3

[0043] Based on 100ml, the prepared eye drops contain:

[0044] Sodium chloride 0.55g, hypromellose 0.06g, boric acid 0.53g, borax 0.05g, ethylparaben 0.03g, water for injection.

[0045] Its preparation method is with above-mentioned embodiment 1.

[0046] The moisture retention rate test was carried out with each embodiment sample and the blank control without adding hypromellose and the eye drops with sodium hyaluronate. The test results are as follows:

[0047] Changes of moisture retention rate of different humectants with storage time

[0048]

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Abstract

The invention provides sodium chloride eye drops containing hydroxypropyl methylcellulose and a preparation method of the sodium chloride eye drops. The eye drops comprise sodium chloride, hydroxypropyl methylcellulose and water for injection, and a bacteriostatic agent and an acid-base regulator can be added. The eye drops have the following prescription and amount based on 100ml: 0.45-0.75g of sodium chloride, 0.03-0.06g of hydroxypropyl methylcellulose, a pH buffer system and the water for injection. The eye drops are long-lasting in function, obvious in effect of treating xerophthalmia, safe and small in side effect.

Description

technical field [0001] The invention relates to a sodium chloride eye drop and a preparation method thereof, in particular to a sodium chloride eye drop containing hypromellose, and belongs to the field of pharmaceutical preparations. Background technique [0002] Dry eye is a common ophthalmic disease, also known as keratoconjunctival sicca, which refers to abnormal tear quality or quantity or abnormal dynamics caused by any reason, resulting in decreased tear film stability, accompanied by eye discomfort and (or ) is a general term for various diseases characterized by ocular surface tissue lesions. In recent years, as TV dramas and computers are widely used in human daily life, the aging population is gradually increasing, and the incidence of dry eye disease is increasing year by year, which seriously affects the normal development of vision of young people and the eye health of middle-aged and elderly people. [0003] The main treatment for dry eye disease is tear supp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K47/38A61K33/14A61P27/04
Inventor 杨亚军徐亮
Owner KANGYA OF NINGXIA PHARMA
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