Medical composition containing fish serine protease and antibacterial compound, and uses thereof

Abstract

The present invention discloses main components, formulations, statuses and clinical uses of a medical composition containing fish serine protease and an antibacterial active compound. The medical composition comprises fish serine protease, an antimicrobial active compound, a medically-acceptable excipient and water for injection, can be prepared into an emulsion, a spraying agent, a liniment, a drop and a gargarisma, has statuses such as a liquid, an emulsion, a paste, a gel, liposome particles, a nanometer gel and microcapsules, and can be used for burning and other skin trauma repairs, bacteriostasis and bacterial killing, eczema, dermatitis, psoriasis vulgaris and other skin infections, bone joint inflammations, and systemic disease prevention and treatments in clinic. According to the present invention, the fish serine protease and the antibacterial compound are combined, wherein the composition retains the fish serine protease activity and contains the bacterial killing bacteriostasis compound, such that the composition has a strong bacterial killing effect, and provides good prevention and treatment effects for a plurality of diseases.

Description

technical field [0001] The present invention relates to applications such as prevention, treatment and nursing of diseases, in particular to the medical composition of fish serine protease and antibacterial compound and its application in the fields of biology, medical treatment, health care, disinfection and the like. Background technique [0002] US Patents 4,801,451 and 4,963,491 disclose a mixture of exogenous and endogenous endopeptidases isolated from Antarctic krill (Euphasia superba) and the use of the mixture as a cleaning solution. US Patent 4,801,451 discloses the use of this enzyme to remove foreign bodies and dead tissue from wounds. EP-A1-0170115 discloses the use of krill enzymes to dissolve blood clots. International patent application WO96 / 24371 discloses the use of a multifunctional proteolytic enzyme extracted from krill, and a family of proteolytic enzymes extracted from fish and crustaceans, and the use of multifunctional enzymes extracted from Antarcti...

AI Technical Summary

Problems solved by technology

However, the above-mentioned cod trypsin and chymotrypsin antibacterial properties have the following defects: 1) when the temperature reaches more than 30 ° C, its activity is quickly lost; 2) its partial efficacy mainly comes from its inhibitory effect on bacteria and viruses, but cannot Kill the bacterium itself; 3) Its antibacterial effect is only obvious at a higher concentration, such as 100 enzyme units

However, we found that many ingredients that can kill bacteria can also easily inactivate cod trypsin and chymotrypsin, such as ethanol, triclosin, etc.

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