Biodegradable medical adhesive, and preparation method and purpose thereof

An adhesive, cyanoacrylic acid technology, applied in nitrile copolymer adhesives, ester copolymer adhesives, non-polymer organic compound adhesives, etc., can solve problems such as difficult degradation and absorption
CN103083718AActive Publication Date: 2013-05-08INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
Publication Date
2013-05-08

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Abstract

The invention relates to a novel medical adhesive which can be subjected to crosslinking copolymerization and which has good biodegradability. A polymer substrate of the adhesive comprises both single alpha-cyanoacrylate and double alpha-diol cyanoacrylate monomer molecules. Olefinic bonds in single alpha-cyanoacrylate structure can be subjected to polymerization under a trace-amount anionic condition. The double alpha-diol cyanoacrylate in the polymer substrate can serve as a crosslinking agent, such that crosslinking copolymerization of the system can be carried out. Chain growth occurs with a three-dimensional multi-point polymerization manner. A gelling speed is fast, and linear polymerization degree of double-bond polymerization is low. A meshed main chain of the solid 3D-body high polymer obtained by polymerization has degradation sites. Degradation product path is clear, and the degradation product can be absorbed. The medical adhesive can be used in wound bonding, bleeding stopping at massive trauma, visceral and soft tissue wound closure, and the like. In addition, the medical adhesive has a potential purpose to be developed into a tissue engineering material.
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Description

technical field

[0001] The invention relates to a medical adhesive, in particular to a biodegradable medical adhesive. The medical adhesive is biodegradable, the degradation product is non-toxic and absorbable, and can be used for skin wound adhesion, tissue adhesion, wound hemostasis, and the like. Background technique

[0002] The emergence of medical adhesives (medical glue) has changed the concept of traditional medicine only relying on needles and threads to suture wounds. By means of bonding, needles and threads can be replaced or assisted. It has the advantages of simple operation and no secondary damage to the wound. It also has the advantage that it can be applied or assisted in the soft tissues, internal organs, bones and other parts that are difficult to be sutured by surgical needles and threads such as the liver and pancreas. In addition, for large-scale superficial bleeding, abrasions, burns, battlefield injuries, field injuries, intestinal leakage, etc., this...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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