Preparation and applications of novel alkyl cage silsesquioxane nanometer hybrid

A technology of silsesquioxane and nano-hybrid, which is applied in the directions of organic silicon compounds, medical preparations with inactive ingredients, and pharmaceutical formulations, etc. The problem of unsatisfactory drug dosage, etc., achieves the effect of favorable loading rate, easy product preparation, and simple reaction process

Inactive Publication Date: 2013-05-08
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Alginic acid is a hydrophilic polysaccharide compound extracted from brown algae. Sodium alginate is easily soluble in water. It is a polyelectrolyte with high charge density and has good biodegradability and compatibility. Seaweed Divalent salts such as calcium acid will gradually undergo ion exchange in different pH environments in the human body to become alginic acid (acidic) or monovalent salt (neutral or alkaline). The monovalent salt formed in the slightly alkaline environment of the small intestine It can dissolve slowly, and th

Method used

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  • Preparation and applications of novel alkyl cage silsesquioxane nanometer hybrid
  • Preparation and applications of novel alkyl cage silsesquioxane nanometer hybrid
  • Preparation and applications of novel alkyl cage silsesquioxane nanometer hybrid

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Embodiment 1 has cage type polysilsesquioxane (POSS-NH 2 ) preparation:

[0018] Put the monomer γ-aminopropyltriethoxysilane, tetraethoxyammonium hydroxide (20%), water, and n-propanol into a 500ml round-bottomed flask in a certain proportion, and magnetically stir the reaction at 50°C After 24 hours, a viscous liquid was obtained. The reaction product was distilled under reduced pressure to remove impurities such as n-propanol and water as much as possible, and extracted with ethanol to remove unreacted monomers, then the product was added to THF, and THF was used as a precipitant to further treat the product , and finally the product was further purified by vacuum drying. The product see diagram 2-1 .

Embodiment 2

[0019] The preparation of embodiment 2 nano-hybrids:

[0020] The POSS-NH obtained above 2 , octyl glycidyl ether, add a certain amount of ethanol, and react at 50°C for 24h. After the reaction, a layered product is obtained, and the lower oily viscous liquid is separated, washed with deionized water and a small amount of ethanol, and dried in vacuum for 24h. A pale yellow transparent viscous liquid was obtained.

Embodiment 3

[0021] Example 3 Hybrid hydrogel xerogel sample preparation:

[0022] Prepare six parts with a mass fraction of 1% sodium alginate solution and a mass fraction of 3% calcium chloride solution, and take the mass ratio of the hybrid to sodium alginate as 0:1, 0.2:1, 0.4:1, 0.6:1, The 0.8:1, 1:1 hybrids were dissolved in a small amount of ethanol, and the sodium alginate solution and the hybrid ethanol solution were fully blended under the condition of high-speed mechanical stirring. Then, each group of sodium alginate solutions was dropped into the magnetic In the stirring calcium chloride solution, the gel particles were obtained, aged for 3 hours, filtered, washed and dried.

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Abstract

The invention relates to a novel alkylation cage silsesquioxane nanometer hybrid prepared in an alkaline solution, wherein a diameter of hybrid molecules is 1-2 nm, a center of the molecule has a cubic cage type structure, eight vertexes are connected with a product prepared through carrying out ring opening addition on propylamino and 2-ethylhexyl glycidyl ether, and the hybrid has strong hydrophobicity. According to the present invention, the hybrid is dispersed in a 1.5 w% sodium alginate aqueous solution through an emulsification and high speed stirring method, and the obtained solution is added to a 3% calcium chloride aqueous solution in a dropwise manner to prepare a nanometer hybrid modified sodium alginate hydrogel, wherein the obtained modified hydrogel has characteristics of enhanced mechanical strength and enhanced stability compared to the pure sodium alginate hydrogel, and hydrophobic drug embedding rate is increased and drug release rate is slowed when the obtained modified hydrogel is used as a drug carrier.

Description

technical field [0001] This research involves the preparation of organic / inorganic hybrid gels, which belongs to the field of functional polymer materials. Background technique [0002] Alginic acid is a hydrophilic polysaccharide compound extracted from brown algae. Sodium alginate is easily soluble in water. It is a polyelectrolyte with high charge density and has good biodegradability and compatibility. Seaweed Divalent salts such as calcium acid will gradually undergo ion exchange in different pH environments in the human body to become alginic acid (acidic) or monovalent salt (neutral or alkaline). The monovalent salt formed in the slightly alkaline environment of the small intestine It can dissolve slowly, and the drug can obtain a much higher release rate than that in the stomach. With the rapid development of pharmaceutical preparations, drug carrier materials with non-toxic, biodegradable, good biocompatibility, slow release and controlled release have become increa...

Claims

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Application Information

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IPC IPC(8): C07F7/21C08J7/00C08J5/18C08L5/04C08K5/549A61K47/36A61K47/24
Inventor 倪才华丁一王诗卉张秀丽秦学飞许升李世尧
Owner JIANGNAN UNIV
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