Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Oral pH responsive intestinal targeting vector as well as preparation method and applications thereof

A responsive, carrier-based technology that can be used in applications, food preparation, and pharmaceutical formulations. It can solve the problems of material consumption, inability to protect acid-sensitive nutrients, and small drug loading, and achieve fast dissolution and good pH response. The effect of sexual intelligence protection function

Active Publication Date: 2015-02-18
SICHUAN UNIV
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current research on intestinal-targeting drug carriers is mostly concentrated at the micron or nanometer level, which has the disadvantages of small drug loading and large amount of materials.
Nutrients currently available on the market are mostly tablets or capsules, and the excipients or carriers used cannot protect acid-sensitive nutrients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oral pH responsive intestinal targeting vector as well as preparation method and applications thereof
  • Oral pH responsive intestinal targeting vector as well as preparation method and applications thereof
  • Oral pH responsive intestinal targeting vector as well as preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] figure 1 It is a schematic diagram of the preparation method of the oral pH-responsive intestinal targeting carrier, and the preparation method of the carrier is as follows:

[0051] (1) Prepare external phase fluid, internal phase fluid, calcium nitrate solution and protamine sulfate solution

[0052] Preparation of the external phase fluid: Add sodium alginate to the sterile water under stirring at normal pressure and room temperature and continue stirring. When the sodium alginate is completely dissolved, an external phase fluid with a concentration of sodium alginate of 20 g / L is formed;

[0053] Preparation of internal phase fluid: the internal phase fluid is the same as the external phase fluid;

[0054] Preparation of calcium nitrate solution: add calcium nitrate to sterile water at normal pressure and room temperature and stir, when the calcium nitrate is completely dissolved, a calcium nitrate solution with a concentration of 100 g / L is formed;

[0055] Prepa...

Embodiment 2

[0063] figure 1 It is a schematic diagram of the preparation method of the oral pH-responsive intestinal targeting carrier, and the preparation method of the carrier is as follows:

[0064] (1) Prepare external phase fluid, internal phase fluid, calcium nitrate solution and protamine sulfate solution

[0065] Prepare an external phase fluid with a sodium alginate concentration of 30 g / L, an internal phase fluid with a sodium alginate concentration of 10 g / L, a calcium nitrate solution with a concentration of 150 g / L, and a fish sulfate solution with a concentration of 1 g / L. Protamine solution, preparation method is with embodiment 1;

[0066] (2) Preparation of calcium alginate gel inner core

[0067] The preparation of monodisperse water-in-water sodium alginate droplets uses the same co-extrusion device as in Example 1, and the external phase fluid and internal phase fluid prepared in step (1) are respectively injected into the external phase fluid and internal phase flui...

Embodiment 3

[0072] figure 1 It is a schematic diagram of the preparation method of the oral pH-responsive intestinal targeting carrier, and the preparation method of the carrier is as follows:

[0073] (1) Prepare external phase fluid, internal phase fluid, calcium nitrate solution and protamine sulfate solution

[0074] Prepare the external phase fluid with a concentration of 10 g / L of sodium alginate, the external phase fluid with a concentration of 30 g / L of sodium alginate, the calcium nitrate solution with a concentration of 50 g / L, and the protamine sulfate with a concentration of 5 g / L Protein solution, preparation method is the same as embodiment 1;

[0075] (2) Preparation of calcium alginate gel inner core

[0076]The preparation of monodisperse water-in-water sodium alginate droplets uses the same co-extrusion device as in Example 1, and the external phase fluid and internal phase fluid prepared in step (1) are respectively injected into the external phase fluid and internal ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
concentrationaaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the field of pH responsive targeting vectors, and provides an oral pH responsive intestinal targeting vector, wherein the vector consists of calcium alginate gel kernels and protamine sulfate layers wrapped by calcium alginate gel kernels, is spherical, and has the particle diameter of 4.1mm-4.6mm. The method for preparing the vector comprises the following steps of: (1) preparing an external phase fluid, an internal phase fluid, a calcium nitrate solution and a protamine sulfate solution; (2) preparing calcium alginate gel kernels; and (3) adsorbing protamine sulfate so as to form the protamine sulfate layers. The invention also provides applications of the oral pH responsive intestinal targeted vector in embedding probiotics, nutrients or medicaments.

Description

technical field [0001] The invention belongs to the field of pH-responsive targeting carrier, and in particular relates to a pH-responsive intestinal-targeting carrier and a preparation method thereof, as well as the application of the carrier in embedding probiotics, nutrients or medicines. Background technique [0002] After probiotics are ingested in sufficient quantities into the host's intestines, they can produce the following health functions for the host: 1) Regulate the intestines, maintain the balance of intestinal flora, and prevent and treat diarrhea; 2) Relieve lactose intolerance and promote the body's nutrient absorption; 3) Enhance immunity; 4) Reduce high blood pressure; 5) Lower cholesterol; 6) Prevent cancer, inhibit tumor growth, etc. Therefore, probiotic products have been widely used in fields such as health care and medicine. However, due to the poor tolerance of probiotics, it is difficult for live bacteria preparations to withstand the effects of lo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/42A61K47/36A61K35/741A61K9/16A61P1/00A61P1/12A61P3/02A61P37/04A61P9/12A61P3/06A61P35/00A23L1/29A23L33/00
Inventor 梅丽褚良银何帆谢锐巨晓洁汪伟
Owner SICHUAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com