Method for preparing drug for treating pediatric esophageal achalasia

Abstract

The invention discloses a method for preparing a drug for treating pediatric esophageal achalasia. The drug is applied to the treatment of pediatric esophageal achalasia. The drug is characterized by being prepared from the following raw pharmaceutical materials in proportioning ratio by weight: fingerleaf rodgersflower rhizome, bombax malabaricum peel, paris polyphylla Sm., luffa cylindrica (L.) Roem., murraya jasminorage, poriacocos (Schw.) Wolf, citrus reticulata Blanco, rtemisia japonica Thunb., trachelospermum jasminoides (Lindl.) Lem., radix puerariae, hordeum vulgare L. and setaria italica Beauv.. The method comprises the following steps of: (1) extracting volatile oil from coarse powder of radix puerariae, bombax malabaricum peel and rtemisia japonica Thunb. for later use; (2) crushing setaria italica (L.) Beauv. into fine powder for later use; (3) carrying out water extraction and alcohol precipitation on fingerleaf rodgersflower rhizome, poriacocos (Schw.) Wolf, citrus reticulata Blanco, trachelospermum jasminoides (Lindl.) Lem., luffa cylindrica (L.) Roem., paris polyphylla Sm., murraya jasminorage and hordeum vulgare L., and drying so as to obtain a preliminary material; and (4) spraying the volatile oil into the preliminary material, adding the fine powder of setaria italica (L.) Beauv., uniformly mixing, sieving by using a 60-mesh sieve, and encapsulating. Proved by clinical trials, the drug prepared by the method has the characteristics of good treatment effect and high safety in the treatment of pediatric esophageal achalasia, so that the method is worthy of clinical application and popularization.

Description

Technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a preparation method of a medicine for treating infantile achalasia. Background technique [0002] Esophageal achalasia (esophageal achalasia) is a disease of esophageal motility disorder, which refers to a disease in which there is no peristalsis in the esophageal body after swallowing, and achalasia of the cardiac sphincter is not good. It is characterized by relaxation disorder of the lower esophageal sphincter (LES) when swallowing, and lack of peristaltic contraction of the smooth muscle segment of the esophagus, which leads to functional obstruction of the esophagus. The cause of this disease is unclear. It may be related to toxins, nutritional deficiencies, genes and local inflammation. Clinical studies have found that mental concerns can aggravate the symptoms of children, consider whether the cortical nerve dysfunction caused by mental stimulation, leading to cen...

AI Technical Summary

Problems solved by technology

However, the above-mentioned drugs are not suitable for use in pediatrics, so now more endoscopic balloon dilation is used, but dilation often requires multiple times to achieve relief, and the recurrence rate is high, and children with severe pain have poor compliance

Therefore, there is currently a lack of medical treatment drugs for children with achalasia.