Copolymer containing lysine residue on side chain and preparation method thereof as well as fibrinolytic functional material

A technology of lysine residue and fibrinolysis function, which is applied in the directions of single-component synthetic polymer rayon, transportation and packaging, rayon manufacturing, etc. The effect of control, simple operation and simple process

Active Publication Date: 2013-07-10
JIANGSU BIOSURF BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods for surface modification of materials often involve mul...

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  • Copolymer containing lysine residue on side chain and preparation method thereof as well as fibrinolytic functional material

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preparation example Construction

[0033] 2. Preparation of copolymers containing lysine residues in their side chains

[0034] The lysine functional monomer is placed in a solution containing an initiator and a vinyl monomer to react, the reaction temperature is 60-80°C, and the reaction time is 2-6 hours; the initiator and the lysine functional monomer and vinyl The molar ratio of the base monomer is 1:100~1:400.

[0035] On the basis of the above, the preparation of fibrinolytic functional materials is carried out:

[0036] The copolymer containing lysine residues in the side chain and the commercially available medical polymer raw materials are physically blended according to a certain mass ratio and subjected to corresponding molding processing to obtain a material with a fibrinolytic function.

[0037] The ε-amino and carboxyl protected lysine described in this technical scheme is ε-amino and carboxyl protected lysine; the described lysine solution is ε-amino and carboxyl protected The dichloromethane o...

Embodiment 1

[0039] Example 1: Preparation of Fibrinolytic Active Polylactic Acid Membrane

[0040] (1) Preparation of lysine functional monomer

[0041]Put 1.36g of lysine hydrochloride whose ε-amino and carboxyl groups are protected by tert-butoxycarbonyl, 0.82g of triethylamine, and 40mL of dry dichloromethane in a 100mL reaction flask, and stir to dissolve. Slowly drop 0.42 mL of methacryloyl chloride into the reaction flask, stir the reaction at room temperature for 6 hours, remove the precipitate by filtration, and remove the solvent by rotary evaporation of the filtrate in vacuo to obtain an intermediate. The intermediate was placed in 20 mL of 28% 1,4-dioxane solution, stirred and reacted at room temperature for 8 hours, and the solvent was removed by vacuum rotary evaporation to obtain lysine functional monomer.

[0042] (2) Preparation of polymethacrylate-(2-hydroxy)ethyl ester copolymer

[0043] Put 0.3g of lysine functional monomer, 3.0g of (2-hydroxy)ethyl methacrylate, 0.02...

Embodiment 2

[0046] Embodiment 2: Preparation of fibrinolytically active polylactic acid nanofibers

[0047] (1) Preparation of lysine functional monomer

[0048] Put 1.36g of lysine hydrochloride whose ε-amino and carboxyl groups are protected by tert-butoxycarbonyl, 0.82g of triethylamine, and 40mL of dry dichloromethane in a 100mL reaction flask, and stir to dissolve. Slowly drop 0.42 mL of methacryloyl chloride into the reaction flask, stir the reaction at room temperature for 6 hours, remove the precipitate by filtration, and remove the solvent by rotary evaporation of the filtrate in vacuo to obtain an intermediate. The intermediate was placed in 20 mL of 28% 1,4-dioxane solution, stirred and reacted at room temperature for 8 hours, and the solvent was removed by vacuum rotary evaporation to obtain lysine functional monomer.

[0049] (2) Preparation of polymethacrylate-(2-hydroxy)ethyl ester copolymer

[0050] Put 0.3g of lysine functional monomer, 3.0g of (2-hydroxy)ethyl methacry...

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Abstract

The invention relates to a copolymer containing a lysine residue on a side chain, a preparation method of the copolymer, and a fibrinolytic functional material prepared on the basis of the copolymer. The preparation method comprises the following steps of: synthesizing a lysine functional monomer; on the presence of an initiator, preparing the copolymer containing the lysine residue at the side chain by carrying out free radical polymerization on the functional monomer and a vinyl monomer; and blending the prepared copolymer with other commercially available medical polymer materials, and processing and molding to prepare a biological medical functional polymer material of which the surface has a fibrinolytic function. When the obtained material contacts with blood, the fibrinolytic system of a human body can be simulated and nascent thrombus on the surface of a material can be dissolved. The copolymer can be adjusted and controlled directly by changing the charging ratio of the lysine functional monomer to a comonomer, so that the process is simple; the copolymer containing the lysine residue on the side chain can be conveniently blended with various commercially available medical polymer materials, and can be subjected to various processing for molding, so that the construction of a fibrinolytic system on the surface of a material is realized while a biological material in a certain shape is prepared, and the universality is strong.

Description

technical field [0001] The invention belongs to the technical field of medical functional polymer materials, and relates to a medical polymer copolymer and its preparation method and application, in particular to a side chain containing lysine residue copolymer and its preparation method and based on the copolymer The prepared fibrinolytic functional material. Background technique [0002] Biomedical materials are widely used in the medical field, but when they are implanted into the body as a heterogeneous body, their blood compatibility is not ideal enough, and blood coagulation and thrombus may still occur. Therefore, the functional modification of biomedical materials to obtain the surface of anticoagulant materials and improve their blood compatibility has become an important measure to promote the application and development of medical materials and devices. [0003] Most modification strategies start from the perspective of inhibiting thrombus formation, or inhibit p...

Claims

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Application Information

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IPC IPC(8): C08F220/28C08F220/58C08F220/18C08L67/04C08L33/14C08L75/04D01F6/92D01F1/10D01F6/94A61L33/06
Inventor 陈红唐增超武照强李丹郑青
Owner JIANGSU BIOSURF BIOTECH CO LTD
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