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Biodegradable barrier-type medicinal packaging bottle and preparation method thereof

A biodegradable packaging bottle technology, applied in the field of pharmaceutical packaging, can solve the problems of poor barrier performance and difficult biodegradation of pharmaceutical packaging bottles, and achieve the effects of good barrier effect, simple and feasible preparation method, and improved barrier property

Active Publication Date: 2013-07-24
山东金阳光医药包装有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to solve the defects of difficult biodegradation and poor barrier properties of the prior art pharmaceutical packaging bottles, and provide a biodegradable barrier pharmaceutical packaging bottle and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A biodegradable barrier pharmaceutical packaging bottle, which is prepared from the following raw materials in parts by weight: poly-β-hydroxybutyrate 150, barium stearate 30, talc powder 10, zeolite powder 10, corn starch 15. Methylcellulose 20, polylactic acid 30, glycerin 20, ethylene glycol 10, Gly-Thr-Gly-Gly short peptide 8 and polyglycolic acid 6.

[0026] The preparation method of above-mentioned packing bottle, comprises the steps:

[0027] First put the raw materials into the reaction tank in turn, and stir while adding the raw materials. After stirring evenly, enter the twin-screw extruder with a length-to-diameter ratio of 40:1 to extrude into a molten state. The temperature is controlled at 200 degrees Celsius, and then the injection machine is used to inject The molten body is quickly injected into the mold, and the mold is closed and cooled to shape; after the mold is opened, the finished product enters the auxiliary mold, and the side is cut and edged by...

Embodiment 2

[0030] A biodegradable barrier pharmaceutical packaging bottle, which is prepared from the following raw materials in parts by weight: poly-β-hydroxybutyrate 150, barium stearate 40, talc powder 20, zeolite powder 20, corn starch 20. Methyl cellulose 30, polylactic acid 36, glycerin 25, ethylene glycol 20, Gly-Thr-Gly-Gly short peptide 10 and polyglycolic acid 8.

[0031] The preparation method of above-mentioned packing bottle, comprises the steps:

[0032] First put the raw materials into the reaction tank in turn, and stir while adding the raw materials. After stirring evenly, enter the twin-screw extruder with a length-to-diameter ratio of 40:1 to extrude into a molten state. The temperature is controlled at 200 degrees Celsius, and then the injection machine is used to inject The molten body is quickly injected into the mold, and the mold is closed and cooled to shape; after the mold is opened, the finished product enters the auxiliary mold, and the side is cut and edged ...

Embodiment 3

[0035] The performance test parameters of the packaging bottle prepared by the present invention are shown in the following table 1, with the 20um thickness prepared in Example 1, the bottom diameter is an example of the packaging bottle of 8cm:

[0036] Table 1

[0037] performance parameters value Exterior Uniform color, no impurities Tensile strength (Mpa) greater than 100 Oxygen throughput (cm3 / m2.24h.0.1Mpa) less than 0.01 Compressive strength (kg / cm2) more than 1kg Intradermal irritation test none Water vapor transmission rate (g / m2.24h) less than 0.01 Biodegradation rate (the amount of carbon dioxide released after composting for 90 days, ISO14885 standard) 98% Hemolysis test Hemolysis rate is less than 1% Allergic reaction Less than I degree

[0038] Conclusion: Through the performance test, it can be found that the degradable performance of the packaging bottle prepare...

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Abstract

The invention belongs to the field of medicinal packaging and discloses a biodegradable barrier-type medicinal packaging bottle. The biodegradable barrier-type medicinal packaging bottle is prepared from poly-beta-hydroxyl butyrate, barium stearate, talcum powder, zeolite powder, corn starch, methyl cellulose, polylactic acid, glycerine, ethylene glycol, oligopeptide and polyglycolic acid. The packaging bottle disclosed by the invention is good in degradability and good in barrier effect and is environment-friendly and pollution-free, and the degradation ratio can reach 98%.

Description

[0001] technical field [0002] The invention belongs to the field of medical packaging, and in particular relates to a biodegradable barrier medicinal packaging bottle and a preparation method thereof. [0003] Background technique: [0004] Pharmaceutical packaging materials refer to the materials used in the manufacture of packaging containers, packaging decoration, packaging printing, packaging and transportation to meet product packaging requirements, including metal, plastic, glass, ceramics, paper, bamboo, wild mushrooms, natural fibers , chemical fibers, composite materials and other main packaging materials, including coatings, adhesives, strapping, decoration, printing materials and other auxiliary materials. [0005] At present, most medicines are packaged in polyethylene plastic bottles and polyester bottles. These packaging bottles have different gas permeability barrier properties and humidity barrier properties. With the development of the pharmaceutical in...

Claims

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Application Information

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IPC IPC(8): C08L67/04C08L3/02C08L1/28C08K5/098C08K3/34C08K5/053C08K5/17A61J1/00
Inventor 朱林徐向阳张继生张雷王广忠
Owner 山东金阳光医药包装有限公司
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