Nanostructured lipid carrier for composite skin lightener and preparation method of composite skin lightener

A technology of nanostructured lipids and complex lipids, which can be used in food preparation, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of easy degradation and discoloration, poor water solubility, rough skin feeling, etc., so as to solubilize drugs and reduce viscosity. , The effect of improving light stability

Active Publication Date: 2014-04-09
SHANGHAI ZHONGYI DAILY CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical purpose of the present invention is to provide a composite whitening agent nanostructured lipid carrier with high loading capacity, good water solubility, good stability and excellent compatibility and its preparation method, which solves the problem of poor water solubility of the composite whitening agent in the prior art , easily degraded and discolored under light, and rough skin feeling

Method used

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  • Nanostructured lipid carrier for composite skin lightener and preparation method of composite skin lightener
  • Nanostructured lipid carrier for composite skin lightener and preparation method of composite skin lightener
  • Nanostructured lipid carrier for composite skin lightener and preparation method of composite skin lightener

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Preparation of Example 1 Composite Whitening Agent Nanostructured Lipid Carrier

[0041] Composition formula

[0042]

[0043] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0044] 1. Weigh 8g of glyceryl monostearate, 4g of vitamin E acetate, and 4g of ruba gum oil, weigh them, put them into a 150mL beaker, put them in a water bath at 65°C and stir at 340r / min until they melt, and use them as the oil phase; At the same time, turn on the high-pressure homogenizer and preheat it with 65°C deionized water;

[0045] 2. Weigh 4072g of poloxamer, 8g of hexaglyceryl monostearate, and 66g of deionized water, put them into a 100mL conical flask with a stopper, and place them in a water bath at 65°C as the water phase;

[0046] 3. Weigh 8g of compound whitening agent and add it to the melted oil phase, stir at 340r / min until completely melted;

[0047] 4. Pour the water phase into the oil phase at one time, and stir at 600r / min until co...

Embodiment 2

[0050] Preparation of Example 2 Composite Whitening Agent Nanostructured Lipid Carrier

[0051] Composition formula

[0052]

[0053] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0054] 1. Weigh 4g of glyceryl monostearate, 8g of acetylated monoglyceride, 12g of diethyl sebacate, and 6g of hexaglyceryl monostearate, weigh them and put them in a 150mL beaker at 70°C Stir in a water bath at 350r / min until it melts, and use it as the oil phase; at the same time, turn on the high-pressure homogenizer and preheat it with 70°C deionized water;

[0055] 2. Weigh 12g of polyoxyethylene-21-stearate and 50g of deionized water, put it into a 100mL conical flask with a stopper, and place it in a 70°C water bath as the water phase;

[0056] 3. Weigh 8g of compound whitening agent and add it to the melted oil phase, stir at 350r / min until completely melted;

[0057] 4. Pour the water phase into the oil phase at one time, and stir at 600r / min unti...

Embodiment 3

[0060] Example 3 Preparation of Composite Whitening Agent Nanostructured Lipid Carrier

[0061] Composition formula

[0062]

[0063] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0064] 1. Weigh 4.67g of caprylic acid glyceride, 1.33g of vitamin E acetate, and 2g of luba gum oil, weigh them, put them into a 150mL beaker, put them in a water bath at 55°C and stir at 300r / min until they melt, and use them as the oil phase ; Simultaneously turn on the high-pressure homogenizer and preheat it with 55°C deionized water;

[0065] 2. Weigh 3g of O-1000, 2g of polyoxyethylene-700 stearate compound, and 83g of deionized water. After weighing, put it into a 100mL conical flask with a stopper, and place it in a water bath at 55°C as the water phase;

[0066] 3. Weigh 4g of compound whitening agent and add it to the melted oil phase, stir at 340r / min until completely melted.

[0067] 4. Pour the water phase into the oil phase at one time, and s...

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Abstract

The invention relates to a nanostructured lipid carrier (NLC) for a composite skin lightener. The composite skin lightener is loaded on the carrier and comprises the following three active ingredients in percentage by weight: 1-50% of phenylethyl resorcinol, 40-89% of turmeric extract, and 1-10% of pepper seed extract; the carrier further comprises an NLC composite lipid material and an emulsifying agent; and the content of the composite skin lightener in percentage by weight is 1-15%. The composite skin lightener is enveloped by using the NLC; and the enveloping process is simple, controllable, and good in repeatability, and overcomes the application bottlenecks that the active substances are not soluble in water, and easily degrades on meeting light to cause color change, and rapid content decease.

Description

technical field [0001] The invention relates to the fields of cosmetics and food, in particular to a nano-scale carrier and a preparation method thereof, in particular to a nano-structured lipid carrier with a composite whitening agent as an active ingredient and a preparation method thereof. Background technique [0002] Whitening is the eternal pursuit of oriental women. The color of human skin mainly depends on the content and distribution of melanin, and the structure, function and quantity of melanocytes directly affect the content of melanin in the skin and are the decisive factors for the production of melanin. The synthesis of melanin must have three basic substances: ①Tyrosine is the main raw material for the manufacture of melanin; ②Tyrosinase is the main rate-limiting enzyme for the conversion of tyrosine into melanin, which is a composition of copper and protein; ③ Tyrosine produces melanin under the action of tyrosinase, which is an oxidation process that must b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/97A61K8/34A61K8/14A61Q19/02A23L1/29A23L33/00
Inventor 赵仕芝董义伟
Owner SHANGHAI ZHONGYI DAILY CHEM CO LTD
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