A sugar-based/sulfonated modified affinity polymer hollow fiber separation membrane, its preparation method and application

Abstract

The invention discloses a glycosyl / sulfonated modified affiliative polymer hollow fiber separating membrane and a preparation method thereof. The membrane is composed of polymer resin, sulfonated polymer resin and saccharide polymer, has a good specificity adsorption effect on LDL (low-density lipoprotein) under optimized raw materials and proportion, is good in stability and biocompatibility, reusable and low in cost, and can be put into large-scale clinical application. The preparation method comprises the following processes of: dissolving the polymer resin, sulfonated polymer resin, saccharide polymer and a pore-foaming agent for the membrane in a dissolvent according to a certain proportion to prepare a uniform spinning membrane-preparing solution, filtering the spinning membrane-preparing solution, defoaming the filtered spinning membrane-preparing solution in vacuum, spinning through a immersion-precipitation phase transformation method to prepare the hollow fiber membrane, and then sufficiently rinsing the prepared hollow fiber membrane in deionized water and ultrapure water in order. The blending dissolving preparation method adopted by the invention has the advantages that the operation is simple and safe and the raw materials are cheap and easily available.

Description

technical field

[0001] The invention belongs to the field of biological separation engineering, and in particular relates to a glycosyl / sulfonated modified affinity polymer hollow fiber separation membrane, its preparation method and application. Background technique

[0002] Cardiovascular disease is the primary disease ("the first killer") that threatens human health. According to the assessment report of the World Health Organization in 2008, the number of people who died of cardiovascular disease accounted for 29% of the total number of deaths in the world. Epidemiological studies and clinical practice have shown that there is a close relationship between cardiovascular disease and the excessive concentration of LDL in the blood, which causes LDL to enter the blood vessel wall and be oxidized into oxidized low-density lipoprotein (ox~LDL).

[0003] Low density lipoprotein (LDL) is the main form of endogenous cholesterol synthesized by the liver and cholesteryl ester tran...

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