A sugar-based/sulfonated modified affinity polymer hollow fiber separation membrane, its preparation method and application

A technology for separation of sulfonated polymers and fibers, applied in chemical instruments and methods, alkali metal compounds, alkali metal oxides/hydroxides, etc. Complicated material preparation process and other issues, to achieve good biocompatibility and excellent stability, reduce medical costs, high selectivity and adsorption rate

Active Publication Date: 2015-10-21
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN200610200095.7 discloses a kind of adsorption material with two kinds of adsorption functional groups of taurine and indole acetic acid. Through the joint action of functional groups, it has a higher adsorption capacity for LDL, and at the same time, it has a relatively high non-specific adsorption for HDL. Small
However, the raw materials of the above-mentioned adsorption materials are expensive and difficult to obtain, and the preparation process of the adsorption materials is relatively complicated, which cannot meet the needs of large-scale clinical use.

Method used

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  • A sugar-based/sulfonated modified affinity polymer hollow fiber separation membrane, its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] According to the ratio (mass ratio) of 25:15:60, dry polysulfone (number average molecular weight = 90000), sulfonated polysulfone (number average molecular weight = 95000, sulfonation degree = 50%), and NMP were slowly Slowly add it into a three-necked flask, stir and dissolve at 90°C, and filter and remove the residue after the solute is completely dissolved to obtain a mixed solution of polysulfone and sulfonated polysulfone; Sulfone and dextran (number average molecular weight = 100,000) were slowly added into a three-necked flask, stirred and dissolved at 90°C, and after the solute was completely dissolved, the slag was removed by filtration to obtain a sugar solution with a concentration of 10%. According to the ratio (mass ratio) of 70:20:10, add the mixed solution of polysulfone and sulfonated polysulfone, sugar solution and porogen PEG400 into the three-necked flask in turn, stir and mix at 90°C for 12h, and then use nitrogen to defoam After 12 hours, the film-...

Embodiment 2

[0034] According to the ratio (mass ratio) of 25:15:60, dry polysulfone (number average molecular weight = 40000), sulfonated polysulfone (number average molecular weight = 60000, sulfonation degree = 5%), and NMP were slowly Slowly add it into a three-necked flask, stir and dissolve at 10°C, and filter and remove the residue after the solute is completely dissolved to obtain a mixed solution of polysulfone and sulfonated polysulfone; Sulfone and dextran (number average molecular weight = 100,000) were slowly added into a three-necked flask, stirred and dissolved at 80°C, and after the solute was completely dissolved, the slag was removed by filtration to obtain a sugar solution with a concentration of 10%. According to the ratio (mass ratio) of 70:20:10, add the mixed solution of polysulfone and sulfonated polysulfone, sugar solution and porogen PEG400 into the three-necked flask in turn, stir and mix at 10°C for 48h, and then use nitrogen to defoam After 48h, the film-making...

Embodiment 3

[0036] According to the ratio (mass ratio) of 20:10:70, dry polysulfone (number average molecular weight = 120000), sulfonated polysulfone (number average molecular weight = 80000, sulfonation degree = 80%), and NMP were slowly Slowly add it into the three-necked flask, stir and dissolve at 50°C, and filter and remove the residue after the solute is completely dissolved to obtain a mixed solution of polysulfone and sulfonated polysulfone; Slowly add the mixture of sulfone, peptidoglycan (number average molecular weight = 100000) and dextran (number average molecular weight = 100000) into the three-necked flask, stir and dissolve at 50 ° C, and filter to remove the residue after the solute is completely dissolved. A sugar solution with a concentration of 15% was obtained. According to the ratio (mass ratio) of 70:20:10, add the mixed solution of polysulfone and sulfonated polysulfone, sugar solution and porogen PEG600 into the three-necked flask in sequence, stir and mix at 50°...

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Abstract

The invention discloses a glycosyl / sulfonated modified affiliative polymer hollow fiber separating membrane and a preparation method thereof. The membrane is composed of polymer resin, sulfonated polymer resin and saccharide polymer, has a good specificity adsorption effect on LDL (low-density lipoprotein) under optimized raw materials and proportion, is good in stability and biocompatibility, reusable and low in cost, and can be put into large-scale clinical application. The preparation method comprises the following processes of: dissolving the polymer resin, sulfonated polymer resin, saccharide polymer and a pore-foaming agent for the membrane in a dissolvent according to a certain proportion to prepare a uniform spinning membrane-preparing solution, filtering the spinning membrane-preparing solution, defoaming the filtered spinning membrane-preparing solution in vacuum, spinning through a immersion-precipitation phase transformation method to prepare the hollow fiber membrane, and then sufficiently rinsing the prepared hollow fiber membrane in deionized water and ultrapure water in order. The blending dissolving preparation method adopted by the invention has the advantages that the operation is simple and safe and the raw materials are cheap and easily available.

Description

technical field [0001] The invention belongs to the field of biological separation engineering, and in particular relates to a glycosyl / sulfonated modified affinity polymer hollow fiber separation membrane, its preparation method and application. Background technique [0002] Cardiovascular disease is the primary disease ("the first killer") that threatens human health. According to the assessment report of the World Health Organization in 2008, the number of people who died of cardiovascular disease accounted for 29% of the total number of deaths in the world. Epidemiological studies and clinical practice have shown that there is a close relationship between cardiovascular disease and the excessive concentration of LDL in the blood, which causes LDL to enter the blood vessel wall and be oxidized into oxidized low-density lipoprotein (ox~LDL). [0003] Low density lipoprotein (LDL) is the main form of endogenous cholesterol synthesized by the liver and cholesteryl ester tran...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D71/68B01D71/08B01D69/08B01J20/26B01J20/28B01J20/30B01D15/08
Inventor 黄小军刘霜徐志康李晶刘洋沈立强叶建荣
Owner ZHEJIANG UNIV
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