Colistin sulfate production method

A technology of colistin sulfate and production method, applied in the field of production of colistin sulfate, can solve the problems of low overall yield, high concentration cost, low purity and the like, achieve system simplification, low valve switching frequency and good operability Effect

Active Publication Date: 2013-08-28
XIAMEN STARMEM TECH
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Problems solved by technology

Although this method does not use solvents in the whole process, which reduces environmental pollution, t

Method used

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  • Colistin sulfate production method
  • Colistin sulfate production method
  • Colistin sulfate production method

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[0040] Example: The raw material liquid is a colistin fermentation liquid pretreated with a ceramic membrane and subjected to a decalcification process. The material liquid is dark brown, the colistin titer is between 350,000 and 400,000 u / ml, and the Ca2+ content is less than or equal to 200ppm. The amount of resin filled in each separation unit is 450mL, and the equipment rotation period is 2100s, which is 35min. The resin flow rate=450 / 35=12.8mL / min, and the fermentation broth feed rate is about 138mL. The amount of resin can be characterized by the ratio of resin volume to feed volume, that is, 12.8:138=1:10.8. In the case of 2100S / revolution, the amount of material liquid that can be processed per unit resin is: 10.8ml material liquid / ml resin; The results of the method for colistin sulfate production are shown in the following table.

[0041]

[0042] As can be seen from the above table, after the raw material is processed by the continuous ion exchange system, the product...

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Abstract

The invention discloses a colistin sulfate production method, which sequentially comprises the following steps: filtering, calcium and magnesium removing-absorption desorption, concentration, desalting, neutralization and spray drying, and is characterized in that the filtering adopts ceramic membrane ultra-filtration filtering, the absorption desorption adopts a continuous ion exchange system filled with a methacrylic acid type carboxylic acid base resin or an acrylic acid carboxylic acid base resin to carry out absorption desorption, and the concentration adopts nano-filtration concentration. The production method has the following advantages that: colistin sulfate is an intracellular product, and cells can be broken when filtration is performed by using a ceramic membrane, such that the colistin sulfate in the colistin sulfate cells can be collected; the equipment is compact, the system is simplified, the pipeline is reduced, and the occupation area is small; the resin consumption is reduced; and the adopted nano-filtration has advantages of high concentration ratio, low energy consumption and the like, and the whole method has advantages of high yield, good purification effect, low production cost and the like.

Description

technical field [0001] The invention relates to the field of colistin sulfate production, in particular to a production method of colistin sulfate. Background technique [0002] Colistin is a polypeptide antibiotic with specific resistance to multidrug-resistant Granz-negative pathogens (such as Pseudomonas aeruginosa). Myxobacterium contains diaminobutyric acid and free amino groups , so it is alkaline, and it is often used as a salt in clinical practice. Currently, it is commercialized in two forms, and colistin sulfate (colistin sulphate, CS) is one of the forms. Colistin sulfate can be used in animals such as pigs, poultry, cattle, and sheep. Because of its strong antibacterial effect, low residue, and low resistance, it is approved as a feed additive or veterinary drug by many countries such as China, the United States, the European Union, and Japan. It can treat animal feeding diseases caused by a variety of germs, and can promote animal biology and improve feed utili...

Claims

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Application Information

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IPC IPC(8): C07K7/62C07K1/36C07K1/34C07K1/18
Inventor 彭广生卢伯福陈洪景虞美辉李振峰雷细良
Owner XIAMEN STARMEM TECH
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