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Novel method for preparing porous crosslinked chitosan microsphere

A technology for cross-linking chitosan and chitosan microspheres, applied in coating and other directions, can solve the problems of high energy consumption, consumption of amino groups, affecting the functional properties of products, etc., and achieves safe preparation process, mild reaction conditions, and preparation steps. simple effect

Active Publication Date: 2013-08-28
上海傲太电子科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its main disadvantages are: the two reactions need to be carried out at high temperature, and the energy consumption is high; the prepared chitosan microspheres still consume part of the amino group, which affects the functional properties of the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. The molecular weight is 120,000 Da, and 5 g of chitosan powders with a deacetylation degree of 95% are dissolved in 1000 mL of hydrochloric acid with a volume concentration of 3%, and fully stirred and dissolved at room temperature to obtain chitosan with a mass fraction of 0.5%. Sol;

[0024] 2. in the chitosan sol solution that step 1 makes, adding particle diameter is the solid chlorinated paraffin powder of 60 microns, pumps in the spray centrifuge after stirring, and the control centrifuge rotating speed is that 8000r / min carry out spray dispersion, spray The chitosan microsphere liquid that goes out is received with the sodium carbonate aqueous solution of pH10. The ratio of the solid chlorinated paraffin powder mass (g) with a particle size of 60 microns to the volume (mL) of the sol with a chitosan mass fraction of 0.5% is 1:5. After the spraying is completed, stir slowly with an electric mixer for 30 minutes, then filter, collect the filter residue and the ...

Embodiment 2

[0029] 1. The molecular weight is 80,000 Da, the 5g chitosan powder that the deacetylation degree is 90% is dissolved in the 250mL hydrochloric acid that the mass fraction is fully stirred and dissolved at room temperature, and the chitosan sol that the mass fraction is 2% is obtained ;

[0030] 2. in the chitosan sol solution that step 1 makes, adding particle diameter is the solid chlorinated paraffin powder of 40 microns, pumps in the spray centrifuge after stirring, and the control centrifuge rotating speed is that 6000r / min carries out spray dispersion, sprays The chitosan microsphere liquid that goes out receives with the sodium carbonate aqueous solution of pH9. The ratio of the solid chlorinated paraffin powder mass (g) with a particle diameter of 40 microns to the sol volume (mL) with a chitosan mass fraction of 2% is 1:3. After the spraying is completed, stir slowly with an electric mixer for 20 minutes, then filter, collect the filter residue and the filtrate, the ...

Embodiment 3

[0035] 1. The molecular weight is 40,000 Da, 5g chitosan powder that the deacetylation degree is 85% is dissolved in the 100mL hydrochloric acid that volume concentration is 1%, fully stirs and dissolves at room temperature, obtains the chitosan that mass fraction is 5% Sol;

[0036] 2. in the chitosan sol solution that step 1 makes, adding particle diameter is the solid chlorinated paraffin powder of 20 microns, is pumped in the spray centrifuge after stirring, and the control centrifuge rotating speed is that 4000r / min carries out spray dispersion, sprays The chitosan microsphere liquid that goes out is received with the sodium carbonate aqueous solution of pH8. The ratio of the solid chlorinated paraffin powder mass (g) with a particle size of 20 microns to the volume (mL) of the sol with a chitosan mass fraction of 5% is 1:2. After the spraying is completed, stir slowly with an electric mixer for 10 minutes, then filter, collect the filter residue and the filtrate, the co...

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Abstract

The invention relates to a novel method for preparing a porous crosslinked chitosan microsphere, and in particular relates to a method for preparing a crosslinked chitosan microsphere by using 1,2-cyclohexanediol diglycidyl ether as a crosslinking agent. According to the novel method, commercially available chitosan, 1,2-cyclohexanediol diglycidyl ether and chlorinated paraffin are used as raw materials, and the porous crosslinked chitosan microsphere is prepared by dissolution, dispersion into spheres, hole preparation, crosslinking and drying. The method has the characteristics of mild reaction conditions, simple preparation steps, high comprehensive resource utilization rate, no harmful substances and the like. The crosslinked chitosan microsphere prepared by using the method has the characteristics of capability of biodegradation, good acid-alkali resistance, good adsorption effect on acid ions and proteins, strong load capacity on heavy metal ions and the like, and can be applied to the field of food, medicine, chemical industry and the like.

Description

1. Technical field [0001] The invention belongs to the technical field of preparing chitosan microspheres from biomedicine and waste water treatment, and in particular relates to a method for preparing crosslinked chitosan microspheres by using 1,2-cyclohexanediol diglycidyl ether as a crosslinking agent. 2. Background technology [0002] Chitosan is the product of deacetylation of chitin. It is the only alkaline polysaccharide that exists in nature. It is insoluble in water and alkaline solution, but soluble in most dilute acids such as hydrochloric acid, acetic acid, naphthenic acid and benzoic acid. It is widely used In the fields of food, medicine, chemical industry and environment. Natural chitosan is a powder. Due to the formation of a large number of hydrogen bonds between molecules, the main active functional group amino group of the polymer is blocked, making it difficult to exchange, adsorb, chelate, and chemically react, which also leads to high mass transfer resi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/36C08J9/26C08J3/24C08J3/12C08L5/08C08K5/1515
Inventor 王丹周茂祥李茹蔡锦华颜李秀周小华
Owner 上海傲太电子科技有限公司
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