Water soluble nutritional compositions comprising cereal beta-glucan and resistant starch

A nutritional composition, a technology of resistant starch, applied in the field of improving the cold water solubility, wettability and dispersibility/miscibility of powder nutritional compositions, can solve the problem of poor dispersibility and miscibility, poor solubility, poor too applicable, etc.

Inactive Publication Date: 2013-10-16
ABBOTT LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although a nutritional composition comprising a combination of cereal β-glucan and Salacia extract has been shown to reduce postprandial glucose levels, it has further been found that the cereal β-glucan component of the composition may have Poor solubility and exhibits poor dispersibility and miscibility, making the composition less suitable for use in ready-to-drink powder form

Method used

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  • Water soluble nutritional compositions comprising cereal beta-glucan and resistant starch
  • Water soluble nutritional compositions comprising cereal beta-glucan and resistant starch
  • Water soluble nutritional compositions comprising cereal beta-glucan and resistant starch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] In this example, various water-soluble dietary fibers (Sunfibre®, Nutriose®, WPG® yeast β-glucan, and Barliv®) alone or in combination with Salacinol (Salacia oblonga extract D) were analyzed Effects on 30-minute postprandial glucose levels. Evaluation of prediabetic (obese rats) and diabetic animal models.

[0088] Postprandial blood glucose levels were assessed in prediabetic (obese) and diabetic Zucker male rats and in diabetic male mice approximately 6-8 weeks of age. Initially, animal body weights were recorded and basal blood glucose measurements were taken prior to fasting. Animals were fasted overnight and then randomized based on their basal glucose levels and assigned into different experimental groups (n=5 to 7 per group).

[0089] Various sample compositions of water soluble fiber and / or belaciferin were prepared. To formulate the sample compositions, a cornstarch suspension was first prepared by mixing 1 gram of cornstarch and 10 ml of 0.5% Tween-80 in d...

Embodiment 2

[0097] In this example, the blood glucose lowering effects of barley-derived β-glucan (Barliv™) and yeast-derived β-glucan (WGP™) were compared in prediabetic (obese) and diabetic animal models. The effects were assessed at time points of 30 minutes, 60 minutes, 90 minutes and 120 minutes postprandial.

[0098] The effect on postprandial blood glucose levels was assessed in obese and diabetic Zucker male rats and in diabetic male mice approximately 6-8 weeks of age. Initially, animal body weights were recorded before fasting and before basal glucose measurements. Animals were fasted overnight and then randomized based on their basal glucose levels and assigned into 3 different experimental groups (n=9 / group).

[0099] Prepare a cornstarch suspension by mixing 1 g of cornstarch and 10 ml of 0.5% Tween-80 in distilled water. The cornstarch suspension was administered to the control group. A second suspension was prepared using the cornstarch suspension prepared in the control...

Embodiment 3

[0105] In this example, the dispersibility and miscibility of barley-derived β-glucan (Barliv®) in water was analyzed. Specifically, the effect of various treatments on the ability of nutritional compositions comprising Barliv® to disperse in water was analyzed. The mixing protocol used simulated the end user and the test samples were introduced into 8 oz of water at room temperature and stirred 10 times clockwise and 10 times counterclockwise using a standard spoon in a 12 oz glass. The final product was visually inspected for the presence of clots, settling and / or delamination.

[0106] Various nutritional compositions including Barliv® are described in the table below. Compositions were subjected to one of the following treatments as further indicated in the table and described below:

[0107] Dry Blending: Barliv® particles are isolated using filler substances with better wettability.

[0108] Coalescing: Barliv® granules are instantiated with a wetting agent such as le...

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Abstract

Disclosed are nutritional compositions comprising agglomerated and / or co-dried particles comprising a cereal beta-glucan and a resistant starch. The agglomerated and / or co-dried particles improve the cold water solubility of the nutritional compositions. The nutritional compositions may be dryblended powdered nutritional compositions including the agglomerated and / or co-dried particles and optionally a Salacia extract.

Description

technical field [0001] The present disclosure relates to water soluble nutritional compositions comprising agglomerated and / or co-dried granules comprising cereal beta-glucan and resistant starch and improving cold water solubility, wettability and dispersibility / miscibility of powdered nutritional compositions sexual method. Background of the invention [0002] Diabetes mellitus is a disorder of carbohydrate metabolism resulting from insufficient insulin production or decreased sensitivity to insulin. In people with diabetes, the body's normal ability to use glucose is impaired, increasing blood sugar levels. Excess levels of glucose are excreted in the urine as more glucose accumulates in the blood. Symptoms associated with diabetes include increased urine volume and frequency, thirst, hunger, weight loss, and weakness. [0003] Diabetes is usually characterized as type 1 or type 2. The earliest manifestations of type 2 diabetes include hyperglycemia following a meal d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/00A23L1/09A23L1/10A23L1/29A23L1/30A23L1/308A61K31/716C08B37/00A23L7/10A23L33/00
CPCA23L1/0522A23V2002/00A23L1/308C08L5/00A23L1/0041C08L3/04A23L1/1643A23L1/0017A23L1/1016A23L1/187A23L1/3002A23P10/20A23P10/47A23L29/212A23L7/115A23L7/198A23L7/126A23L9/10A23L33/00A23L33/105A23L33/21A61P3/02A61P43/00A61P3/10A23V2200/328A23V2250/5034A23V2250/5118
Inventor R.索马瓦特G.C.帕特尔
Owner ABBOTT LAB INC
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