Preparation method of all-trans tretinoin solid lipid nanoparticles
A technology of solid lipid nano and all-trans retinoic acid, which is applied in the direction of microcapsules, nanocapsules, metabolic diseases, etc., can solve problems such as the difficulty of finding organic solvents and the inability to use lipid nanoparticles, so as to reduce energy consumption, The effect of enhanced optical stability and simplified production process
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Embodiment 1
[0024] Embodiment 1: The preparation method of all-trans retinoic acid solid lipid nanoparticles described in this embodiment comprises the following steps:
[0025] Step 1: Preparation of the oil phase
[0026] 25 mg of all-trans retinoic acid and 500 mg of glyceryl behenate were added to 50 mL of absolute ethanol solution to obtain a lipid concentration of 10 mg / mL and a drug concentration of 0.5 mg / mL. The solution is yellow and turbid at room temperature. The obtained solution was heated in a water bath at 75° C. for 30 s to obtain a clear and transparent oil phase solution.
[0027] Step 2: Preparation of the aqueous phase
[0028] Add 10 g of Poloxamer 188 to 500 mL of distilled water to prepare an aqueous solution of Poloxamer 188 with a concentration of 20 mg / mL, cool it down to 5 °C in an ice-water bath, and store it in a refrigerator at 4 °C for preparation of solid lipid nanoparticles .
[0029] Step 3: Continuous production of solid lipid nanoparticles in a sta...
Embodiment 2
[0036] Embodiment 2: The preparation method of all-trans retinoic acid-loaded solid lipid nanoparticles described in this embodiment comprises the following steps:
[0037] Step 1: Preparation of the oil phase
[0038] Add 25mg of all-trans retinoic acid and 500mg of glyceryl behenate into 50mL of absolute ethanol solution, and the solution is yellow and turbid at room temperature. The resulting lipid concentration was 10 mg / mL and the drug concentration was 0.5 mg / mL. The obtained solution was heated in a water bath at 75° C. for 30 s to obtain a clear and transparent yellow oil phase solution.
[0039] Step 2: Preparation of the aqueous phase
[0040] Add 10 g of Tween-80 to 500 mL of distilled water to prepare a Tween-80 aqueous solution with a concentration of 20 mg / mL, cool to 5°C in an ice-water bath, and store in a refrigerator at 4°C for preparation of solid lipid nanoparticles.
[0041] Step 3: Continuous production of solid lipid nanoparticles in a static mixer
...
Embodiment 3
[0048] Embodiment 3: The preparation method of all-trans retinoic acid-loaded solid lipid nanoparticles described in this embodiment comprises the following steps:
[0049] Step 1: Preparation of the oil phase
[0050] Add 50 mg of all-trans retinoic acid and 500 mg of glyceryl behenate into 50 mL of absolute ethanol solution, and the solution is yellow and turbid at room temperature. The resulting lipid concentration was 10 mg / mL, and the drug concentration was 1 mg / mL. The obtained solution was heated in a water bath at 75° C. for 30 s to obtain a clear and transparent yellow oil phase solution.
[0051] Step 2: Preparation of the aqueous phase
[0052] Add 10 g of Tween-80 to 500 mL of distilled water to prepare a Tween-80 aqueous solution with a concentration of 20 mg / mL, cool to 5°C in an ice-water bath, and store in a refrigerator at 4°C for preparation of solid lipid nanoparticles.
[0053] Step 3: Continuous production of solid lipid nanoparticles in a static mixer ...
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