High-specificity sulfanilamide imprinting quantum dot fluorescent sensor and preparation method thereof

A fluorescence sensor, high-specificity technology, applied in chemical instruments and methods, fluorescence/phosphorescence, instruments, etc., to achieve the effect of small steric hindrance, simple preparation method, and reduction of non-specific adsorption

Inactive Publication Date: 2017-11-07
CHANGAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These three articles all construct molecularly imprinted quantum dot fluorescent sensor systems through the interaction of template molecules-functional monomers, but the construction system of molecularly imprinted quantum dot fluorescent sensor tailored only for template molecular weight has not been reported yet.

Method used

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  • High-specificity sulfanilamide imprinting quantum dot fluorescent sensor and preparation method thereof
  • High-specificity sulfanilamide imprinting quantum dot fluorescent sensor and preparation method thereof
  • High-specificity sulfanilamide imprinting quantum dot fluorescent sensor and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] In this example, the highly specific sulfonamide-imprinted quantum dot fluorescent sensor uses amino- and vinyl-modified silica microspheres as the carrier, and octadecyl-p-vinylbenzyl-dimethylammonium chloride-modified cadmium telluride quantum dots It is a fluorescent material, sulfonamide is used as a template molecule, acrylamide is used as a functional monomer, ethylene glycol dimethacrylate is used as a crosslinking agent, and 2,2-azobisisobutyronitrile is used as an initiator, and it is prepared by precipitation polymerization made. Its preparation method specifically comprises the following steps:

[0052] Step 1, the preparation of amino- and vinyl-modified silica microspheres:

[0053] Step 101, adding 100 mL of ethanol and 15 mL of ammonia water to 40 mL of deionized water and stirring evenly to form a mixed solution, then adding 10 mL of tetraethyl orthosilicate to the mixed solution, and continuing to stir for 2 hours to obtain silica microspheres;

[005...

Embodiment 2

[0063] In this example, the highly specific sulfonamide-imprinted quantum dot fluorescent sensor uses amino- and vinyl-modified silica microspheres as the carrier, and octadecyl-p-vinylbenzyl-dimethylammonium chloride-modified cadmium telluride quantum dots It is a fluorescent material, sulfonamide is used as a template molecule, acrylamide is used as a functional monomer, ethylene glycol dimethacrylate is used as a crosslinking agent, and 2,2-azobisisobutyronitrile is used as an initiator, and it is prepared by precipitation polymerization made. Its preparation method specifically comprises the following steps:

[0064] Step 1, the preparation of amino- and vinyl-modified silica microspheres:

[0065] Step 101, adding 120 mL of ethanol and 25 mL of ammonia water to 60 mL of deionized water and stirring evenly to form a mixed solution, then adding 10 mL of tetraethyl orthosilicate to the mixed solution, and continuing to stir for 2 hours to obtain silica microspheres;

[006...

Embodiment 3

[0075] In this example, the highly specific sulfonamide-imprinted quantum dot fluorescent sensor uses amino- and vinyl-modified silica microspheres as the carrier, and octadecyl-p-vinylbenzyl-dimethylammonium chloride-modified cadmium telluride quantum dots It is a fluorescent material, sulfonamide is used as a template molecule, acrylamide is used as a functional monomer, ethylene glycol dimethacrylate is used as a crosslinking agent, and 2,2-azobisisobutyronitrile is used as an initiator, and it is prepared by precipitation polymerization made. Its preparation method specifically comprises the following steps:

[0076] Step 1, the preparation of amino- and vinyl-modified silica microspheres:

[0077] Step 101, adding 110 mL of ethanol and 20 mL of ammonia water to 50 mL of deionized water and stirring evenly to form a mixed solution, then adding 10 mL of tetraethyl orthosilicate to the mixed solution, and continuing to stir for 2 hours to obtain silica microspheres;

[007...

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Abstract

The invention discloses a high-specificity sulfanilamide imprinting quantum dot fluorescent sensor. The high-specificity sulfanilamide imprinting quantum dot fluorescent sensor is prepared by taking an amino and vinyl modified silicon dioxide microsphere as a carrier, an octadecyl-p-vinylbenzyl-dimethyl ammonium chloride modified cadmium telluride quantum dot as a fluorescent material, sulfanilamide as a template molecule, acrylamide as a functional monomer, ethylene glycol dimethacrylate as a cross-linking agent and 2,2-azobisisobutyronitrile as an initiator through a precipitation polymerization method. Furthermore, the invention further discloses a preparation method of the high-specificity sulfanilamide imprinting quantum dot fluorescent sensor. The high-specificity sulfanilamide imprinting quantum dot fluorescent sensor disclosed by the invention has good optical stability and high specificity and high sensitivity on the sulfanilamide, and can be used for rapidly identifying and detecting sulfonamide antibiotics on the scene; meanwhile, the preparation method is simple and convenient, low in equipment requirement and easy to realize.

Description

technical field [0001] The invention belongs to the technical field of preparation of environmental functional materials, and in particular relates to a highly specific sulfonamide imprinted quantum dot fluorescence sensor and a preparation method thereof. Background technique [0002] Sulfonamide antibiotics are a class of synthetic antibiotics with para-aminobenzenesulfonamide as the basic structure. Because of their broad antibacterial spectrum and stable properties, they are widely used in the prevention and treatment of animal diseases. They are usually used as feed additives to sub-treat Dose added to animal feed. Sulfonamide antibiotics will not be completely absorbed by passive objects. About 50% to 90% of sulfonamide antibiotics will be excreted into soil, water and plants in the form of drug prototypes or metabolites, and then transferred to the human body through bioaccumulation. hazard to human health. At present, sulfonamide antibiotic residues in the environm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F292/00C08F220/56C08F222/14G01N21/64C09K11/02C09K11/88
CPCC08F292/00C09K11/025C09K11/88G01N21/6428G01N21/643G01N2021/6432C08F222/102
Inventor 卫潇秦昉巩兴晖李辰王震洪
Owner CHANGAN UNIV
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