Allopurinol sustained-release pellet and preparation method and preparation thereof

A technology of sustained-release pellets and sustained-release preparations, applied in the field of medicine, can solve the problems of increasing the difficulty of preparation, complicated preparation process, and reducing the relative content of allopurinol, so as to achieve the effects of reducing types and dosage and simplifying formula

Inactive Publication Date: 2013-12-04
HYBIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the addition of these auxiliary materials can ensure the sustained-release performance of allopurinol sustained-release preparations, it also increases the difficulty of preparation and makes the preparation process complicated. Coating can prepare allopurinol sustained-release preparations
It can be seen that the addition of excipients not only reduces the relative content of allopurinol in allopurinol sustained-release preparations, but also forces patients to take in excipients during the course of taking them, and the preparation process is complicated and the cost is high

Method used

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  • Allopurinol sustained-release pellet and preparation method and preparation thereof
  • Allopurinol sustained-release pellet and preparation method and preparation thereof
  • Allopurinol sustained-release pellet and preparation method and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] The preparation of embodiment 1 allopurinol sustained-release pellets

[0060] Weigh each component:

[0061]

[0062] Pass allopurinol through a 80-mesh sieve, mix evenly with microcrystalline cellulose, and put it into the hopper of a centrifugal granulator. Put the microcrystalline cellulose ball core into the centrifugal granulator, turn on the fan, turn on the main engine at a speed of 200rpm, put the silicone tube of the peristaltic pump into the Eudragit L30D55 ​​water dispersion, the peristaltic pump speed at 15rpm, and the feeding speed at 5rpm, Dosing by powder layering. While spraying the water dispersion while feeding, adjust the feeding speed and the speed of the peristaltic pump so that the water dispersion is just used up when the mixed material is used up. After feeding, the main machine continued to run for 5 minutes and then stopped to prepare allopurinol sustained-release pellets, which were dried in an oven at 40°C for 2 hours to obtain the prod...

Embodiment 2

[0063] The preparation of embodiment 2 allopurinol sustained-release pellets

[0064] Weigh each component:

[0065]

[0066] Pass allopurinol through an 80-mesh sieve, mix with starch evenly, and set aside. Sodium alginate is dissolved in purified water to form a gel-like solution, which is used as a binder to make a soft material for the mixture. Put the soft material into the feed hopper of the extrusion-spheronizer, the screen aperture is 1mm, the extrusion frequency is 20Hz, and the spheronization frequency is 30Hz, and the prepared allopurinol sustained-release pellets are dried in an oven at 40°C for 2 hours to obtain .

Embodiment 3

[0067] The preparation of embodiment 3 allopurinol sustained-release pellets

[0068] Weigh each component:

[0069] Allopurinol 250g

[0070] Eudragit S100 20g

[0071] Ethanol 200g

[0072] Pass allopurinol through an 80-mesh sieve and set aside. Dissolve Eudragit S100 in ethanol to form a solution with high viscosity, which is used as an adhesive for soft materials made of allopurinol. Put the soft material into the feed hopper of the extrusion-spheronizer, the screen aperture is 1mm, the extrusion frequency is 20Hz, and the spheronization frequency is 30Hz, and the prepared allopurinol sustained-release pellets are dried in an oven at 40°C for 2 hours to obtain .

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Abstract

The invention relates to the technical field of medicine, in particular to an allopurinol sustained-release pellet, and a preparation method and a preparation thereof. The allopurinol sustained-release pellet comprises the following components in parts by weight: 30-95 parts of allopurinol and 1-20 parts of anionic polymer, and further comprises a diluent or a pellet core. According to the allopurinol sustained-release pellet, the anionic polymer serves as both an adhesive and a sustained release material, and no additional adhesive is needed, so that the types and consumption of auxiliary materials are reduced, and the relative content of allopurinol in the pellet is improved. In addition, as the anionic polymer is applied in the pellet skeleton, the step of coating the sustained-release material is omitted, and accordingly, the preparation steps are reduced. Therefore, the allopurinol sustained-release pellet simplified not only the formula but also the preparation technology.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an allopurinol sustained-release pellet and a preparation method and preparation thereof. Background technique [0002] Allopurinol, also known as allopurinol, is an isomer of hypoxanthine. It is a white or off-white crystalline powder, almost odorless, and has a melting point above 350°C. Allopurinol is easily soluble in alkaline solution, slightly soluble in water or ethanol, and insoluble in chloroform. [0003] Allopurinol reduces the synthesis of uric acid by competitively inhibiting the activity of xanthine oxidase to treat gout. Allopurinol is mainly used in the inter-attack and chronic phase of gout, and it is suitable for primary and secondary gout with excessive uric acid production, allergy or ineffectiveness to uricosuric drugs, and inappropriate use of uric acid drugs (such as renal insufficiency). Gout patients to control hyperuricemia. Allopurinol can also be u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/52A61K9/00A61K31/519A61K47/38A61K47/36A61K47/32A61P19/06
Inventor 左灵静陶安进马亚平袁建成
Owner HYBIO PHARMA
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