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A kind of cefaclor capsule and preparation method thereof

A technology of Keluo capsule and cefaclor, which is applied in the field of medicine, can solve the problems of poor quality stability of cefaclor preparations, stratification phenomenon, difficulty in ensuring dosage and efficacy, etc.

Active Publication Date: 2016-05-18
回音必集团浙江齐齐制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The quality of cefaclor raw materials is unstable and easy to degrade under humid and hot conditions. Therefore, the quality stability of cefaclor preparations currently on the market is generally poor, and the preparations need to be kept away from light and sealed.
In addition, because cefaclor is slightly soluble in water, the capsules usually have the problem of poor suspending effect. After adding a certain amount of water to dissolve, the solution suspending effect is poor and stratification occurs. It is difficult to ensure the dosage when taking. affect the efficacy of the drug

Method used

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  • A kind of cefaclor capsule and preparation method thereof
  • A kind of cefaclor capsule and preparation method thereof
  • A kind of cefaclor capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018]

[0019]

[0020] Preparation Process:

[0021] Cefaclor passed through a 100-mesh sieve, KollicoatIR (3:1) was dissolved in absolute ethanol, cefaclor was added, stirred evenly and dried under reduced pressure to remove ethanol, the dried granules were mixed evenly with sucrose passed through a 100-mesh sieve, Packed in capsules.

Embodiment 2

[0023]

[0024] Preparation Process:

[0025] Cefaclor passed through a 100-mesh sieve, KollicoatIR (3:1) was dissolved in absolute ethanol, added cefaclor, stirred evenly and dried under reduced pressure to remove ethanol, the dried granules were mixed with mannitol and lactose passed through a 100-mesh sieve Mix evenly, fill capsules and pack.

Embodiment 3

[0027]

[0028] Preparation Process:

[0029] Pass cefaclor through a 100-mesh sieve, dissolve KollicoatIR (3:1) in absolute ethanol, add cefaclor, stir evenly and dry under reduced pressure to remove ethanol, mix the dried granules with mannitol and sucrose evenly, and fill capsules Package. Comparative Example 1

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PUM

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Abstract

The invention discloses a cefaclor capsule and a preparation method thereof. The preparation is obtained by mixing a cefaclor inclusion complex and pharmaceutically acceptable auxiliary materials. The preparation method of the cefaclor inclusion complex comprises the following steps: dissolving polyvinyl alcohol-polyethylene glycol grafted copolymer (Kollicoat IR) in ethyl alcohol, adding cefaclor, carrying out reduced-pressure drying for removing ethyl alcohol while stirring, and filing into capsules, thus obtaining the cefaclor capsules. The cefaclor capsule is good in stability, high in dissolve-out speed, simple in production technique, and suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a cefaclor capsule and a preparation method thereof. Background technique [0002] Cephalosporins play a bactericidal effect by inhibiting bacterial cell wall synthesis and are stable to most β-lactamases. Many strains producing penicillinase and cephalosporinase are still sensitive to cephalosporins. Cephalosporins in vitro and in vivo against Gram-positive cocci such as pneumococcus, Streptococcus pyogenes, Gram-negative bacilli such as influenza bacilli (including enzyme-producing strains), Moraxella catarrhalis (including enzyme-producing strains) , Escherichia coli, Proteus mirabilis, and Neisseria gonorrhoeae (including enzyme-producing strains) all have good antibacterial effects. Effects of cephalosporins on Streptococcus pneumoniae, Bacillus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Pasteurella multocida, Providencia sp., Salmonella sp., Shig...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K31/545A61K47/48A61P31/04
Inventor 王大冲王建黄凤君
Owner 回音必集团浙江齐齐制药有限公司
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