Medical degradable bioglass/phytic acid composite coating on surface of magnesium alloy and preparation method thereof

A technology of biological glass and composite coating, applied in the direction of coating, etc., can solve the problems of poor bonding with magnesium alloy matrix, poor degradability, loose outer layer, etc., and achieve good cell adhesion and growth, good biological activity, The effect of uniform structure

Inactive Publication Date: 2013-12-18
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reaction between phytic acid and magnesium alloy can form a multi-layer chemical conversion film on the surface of magnesium alloy. However, the outer layer of this conversion film is loose and not dense, and it is easy to crack and fall off in simulated body fluids. A single phytic acid conversion film Protects magnesium alloys only for a very short period of time
In summary, although a single bioglass-coated medical magnesium alloy can improve the biological activity of the material, it has poor bonding with the magnesium alloy matrix.
The hybrid coating composed of bioactive glass and polymer is slightly less degradable in SBF solution
The degradation products of certain polymers will have certain side effects on the human body, which will hinder the repair process of damaged parts in the body.

Method used

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  • Medical degradable bioglass/phytic acid composite coating on surface of magnesium alloy and preparation method thereof
  • Medical degradable bioglass/phytic acid composite coating on surface of magnesium alloy and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] The bioglass 45S5 system is selected, in which SiO 2 -CaO-Na 2 O-P 2 o 5 The mass fraction ratio is: 45:24.5:24.5:6, and the selected mesoporous templating agent is F127.

[0035] Step 1: Preparation of mesoporous bioglass coating

[0036] First, dissolve 0.87g of F127 in 72ml of absolute ethanol, stir to clarify, and use it as a template agent. Dissolve 1.38g of sodium nitrate and 2.12g of calcium nitrate in 40ml of deionized water to prepare an inorganic salt solution for use. Choose tetraethyl orthosilicate, 0.1M dilute nitric acid, and triethyl phosphate as raw materials, mix according to the volume ratio of 30:20:3, stir for 30 minutes, add template agent and inorganic salt solution in turn, and then hydrolyze for 2 hours to end. The prepared sol can be used after standing for 18 hours. The magnesium alloy matrix is ​​processed into a block of 10mm×10mm×2mm, using 800 # ~2000 # Polished with SiC sandpaper, and then cleaned with deionized water. The polished...

Embodiment 2

[0041] The bioglass 45S5 system is still used, and the mesoporous template agent used is F127.

[0042] Step 1: Preparation of mesoporous bioglass coating

[0043] First, dissolve 0.87g of F127 in 72ml of absolute ethanol, stir to clarify, and use it as a template agent. Dissolve 1.38g of sodium nitrate and 2.12g of calcium nitrate in 40ml of deionized water to prepare an inorganic salt solution for use. Choose ethyl orthosilicate, 0.1M dilute nitric acid, and triethyl phosphate as raw materials, mix according to the volume ratio of 30:20:3, stir for 45 minutes, add template agent and inorganic salt solution in sequence, and then hydrolyze for 1 hour to end. The prepared sol can be used after standing for 24 hours. The magnesium alloy matrix is ​​processed into a block of 10mm×10mm×2mm, using 800 # ~2000 # Polished with SiC sandpaper, and then cleaned with deionized water. The polished sample was ultrasonically cleaned with ethanol for about 2 to 5 minutes, and repeated 2 ...

Embodiment 3

[0048] The bioglass 45S5 system is still used, and the mesoporous template agent used is F127.

[0049] Step 1: Preparation of mesoporous bioglass coating

[0050] First, dissolve 0.87g of F127 in 72ml of absolute ethanol, stir to clarify, and use it as a template agent. Dissolve 1.38g of sodium nitrate and 2.12g of calcium nitrate in 40ml of deionized water to prepare an inorganic salt solution for use. Choose tetraethyl orthosilicate, 0.1M dilute nitric acid, and triethyl phosphate as raw materials, mix according to the volume ratio of 30:20:3, stir for 1 hour, add template agent and inorganic salt solution in turn, and then hydrolyze for 1 hour to end. The prepared sol can be used after standing for 36 hours. The magnesium alloy matrix is ​​processed into a block of 10mm×10mm×2mm, using 800 # ~2000 # Polished with SiC sandpaper, and then cleaned with deionized water. The polished sample was ultrasonically cleaned with ethanol for about 2 to 5 minutes, and repeated 2 to ...

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Abstract

The invention relates to a medical degradable bioglass / phytic acid composite coating on the surface of magnesium alloy and a preparation method thereof. The medical degradable bioglass / phytic acid composite coating is characterized in that an inner layer of the composite coating is a bioglass 45S5 coating with the mesoporous diameter in the range from 2 to 5nm, and an outer layer of the composite coating is a phytic acid coating with uniform and compact structure. The thickness of the composite coating is in the range from 0.6 to 1.2 micrometers, the composite coating has very good combination property with a magnesium alloy matrix, and the combination strength reaches 6-15MPa. The average degradation rate of the sample soaked in SBF (Simulated Body Fluid) is 6.76*10<-7>g / (mm<2>h) within 240h. The phytic acid coating is prepared outside the mesoporous bioglass, so that phytic acid magnesium is generated through the reaction between phytic acid and the magnesium alloy so as to block the pores of the mesoporous glass, thus the degradation period of the magnesium alloy is effectively adjusted and controlled, the biocompatibility of the material can be improved, and the generation of apatite is accelerated and induced.

Description

technical field [0001] The invention relates to a preparation method of a bioglass / phytic acid composite coating on the surface of a medical magnesium alloy, and belongs to the technical field of preparation of biomedical materials. Background technique [0002] Traditional medical alloys such as titanium alloys, stainless steel and other materials, due to their non-degradability, are likely to cause thrombus, physical stimulation, local inflammation, and vascular restenosis at the implanted site in the human body. Second operations are often required to avoid these problems, thereby Bring physical and economical burden to patients. Humans have an urgent need for new medical alloy materials. The biggest requirement for a new generation of medical alloys is to expect the alloy to be degradable and biocompatible in the human body, so as to effectively solve the problems that have always existed in the clinical application of traditional medical alloys. question. Magnesium al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/28
Inventor 蔡舒李妍黄凯张睿悦叶新羽
Owner TIANJIN UNIV
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