A kind of artificial cell membrane material applicable to light-induced grafting and its synthesis method

Abstract

The invention discloses artificial cell membrane materials applied to photoinduction stem grafting and a synthesis method of the artificial cell membrane materials. The synthesis method of the artificial cell membrane materials comprises the following steps that 2-(dodecyl trithiocarbonate)-2- methyl propionic acid, dicyclohexyl carbodiimide, 4- dimethylamino pyridine and dichloromethane are added into a flask, all the components are stirred and dissolved under the protection of nitrogen, azide ethanol is dropwise added and stirred, washing is carried out through diluted hydrochloric acid and distilled water, solvents are removed through a reduced pressure distillation method, and a yellow oily liquid a is obtained; MPC, a midbody a, azo different nitrile and absolute ethyl alcohol are added into a boiling tube and are evenly dissolved, then after the nitrogen is removed through three times of 'vacuumizing-induction of highly pure nitorgen' operations on the boiling tube, and reaction away from light is carried out on the boiling tube in a sealed mode under the protection of highly pure nitrogen; the reaction liquid is precipitated through trichloromethane / diethyl ether mixed solvents, and solid products are collected. By means of the technical scheme, the artificial cell membrane materials have good biocompatibility, achieve the various effects of restraining of protein adsorption, anticoagulation, surface lubrication and the like, and have good medical prospects.

Description

technical field [0001] The invention relates to an artificial cell material and a synthesis method thereof, in particular to an artificial cell membrane material applicable to light-induced grafting and a synthesis method thereof. Background technique [0002] 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymer is a new biomimetic medical material, because it can form a thin film with a cell membrane structure on the surface of the material, it is also called an artificial cell membrane. This material can exert good water affinity, inhibit protein adsorption and cell adhesion, surface lubrication and other effects, and has good biocompatibility. These characteristics make it widely used in biomedical fields such as artificial hearts, artificial blood vessels and stent , biochips and other aspects have a good application potential. [0003] At present, there are three main methods for preparing artificial cell membrane coatings on the surface of medical materials: one is ...

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Problems solved by technology

[0003] At present, there are three main methods for preparing artificial cell membrane coatings on the surface of medical materials: one is to directly coat the MPC polymer on the surface of the material, and rely on physical adsorption to form an artificial cell membrane layer. The disadvantage of this method is the combination of the coating Low strength, not conducive to long-term use

The second is to introduce reactive chemical groups, such as carboxyl groups, into the MPC polymer, and form a relatively stable artificial cell membrane layer through chemical bonding on the surface of the material. The disadvantage of this method is that it has poor universality and can only be used for specific active chemicals. group material

The third is to grow MPC polymer chains on the surface of the material through Atom Transfer Radical Polymerization (ATRP) to form an artificial cell membrane layer. The disadvantage of this method is that the metal complex used in the reaction process is easy to cause the surface of the material to pollution, complex treatment process

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