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Drug for treating blood diseases, preparation method, and applications thereof

A blood disease and drug technology, applied in the direction of blood disease, drug combination, medical formula, etc., can solve the aggravation of the disease, side effects and other problems, and achieve the effect of improving bone marrow hematopoiesis, improving immunity, and recovering blood indicators

Active Publication Date: 2015-05-20
杜丽娟 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinical treatment is mainly oral western medicine cyclosporin A. According to the condition, it is combined with Anxiong or Stanozolol, as well as prednisone, methylprednisolone and other drugs. After long-term use, the side effects caused by western medicine will often appear gradually, and even often appear. The condition worsened after being forced to stop western medicine due to obvious side effects

Method used

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  • Drug for treating blood diseases, preparation method, and applications thereof
  • Drug for treating blood diseases, preparation method, and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the preparation of medicinal powder of the present invention

[0029] Take by weighing each raw material medicine according to following proportioning by weight: Codonopsis 43 parts, Radix Astragali 43 parts, Rehmannia glutinosa 43 parts, Rehmannia glutinosa 43 parts, Antler gum 43 parts, Donkey-hide gelatin 43 parts, Chinese yam 43 parts, Atractylodes macrocephala 36 parts, Poria cocos 43 parts, 24 parts of psoralen, 36 parts of Yizhi kernel, 36 parts of dodder seed, 36 parts of privet fruit, 29 parts of medlar, 29 parts of white peony root, 36 parts of Polygonum multiflorum, 29 parts of malt, 29 parts of angelica, 36 parts of salvia miltiorrhiza, 29 parts of peach kernel 29 parts, 29 parts of Radix Paeoniae Rubra, 43 parts of Agrimony, 36 parts of Oujie, 29 parts of Fructus Amomum, 29 parts of fried jujube kernels, 29 parts of Eclipta, 36 parts of Forsythia, 36 parts of paeonol. The above-mentioned preparation process of the present invention is The abov...

Embodiment 4

[0032] Embodiment 4: the effect of powder of the present invention on aplastic anemia mouse model

[0033] 1 material

[0034] 1.1 Animals 120 Kunming mice, male, 18-22g, grade 2, provided by the Experimental Animal Center of Academy of Military Medical Sciences, license number: SCXK-(Army) 2002-001.

[0035] 1.2 Drugs

[0036] 1.2.1 The present invention: prepared by our laboratory, batch number 20121012

[0037] 1.2.2 Compound Soapan Pills: Shaanxi Haoqijun Pharmaceutical Co., Ltd. Batch No. 20050412

[0038] 1.2.3 Cyclophosphamide: 0.2 / bottle, Jiangsu Hengrui Medicine Co., Ltd. Batch No. 05022221

[0039] 1.2.4 Toluene: analytically pure, produced by Beijing Chemical Plant

[0040] 1.3 Experimental equipment

[0041] 1.3.1 Toluene inhalation device: volume 0.8×0.55×0.45, add toluene 5.94g.

[0042] 1.3.2 Animal Laboratory: Animal Experiment Center of the 302nd Hospital of the People's Liberation Army, Level 2 Animal Laboratory

[0043] 1.3.3 Complete blood cell analyze...

Embodiment 5

[0063] Embodiment 5: The therapeutic effect of powder of the present invention on clinical aplastic anemia patients

[0064] Diagnosis of aplastic anemia: pancytopenia, reticulocyte <0.01, increased percentage of lymphocytes. The blood picture meets at least two of the following items:

[0065] (1)①Hemoglobin9 / L③Neutrophils9 / L. (2) Generally without hepatosplenomegaly. (3) Reduced (<50% of normal) or severely reduced (<25% of normal) bone marrow hyperplasia, decreased hematopoietic cells, increased proportion of non-hematopoietic cells, empty bone marrow granules, and bone marrow biopsy showed decreased hematopoietic tissue. (4) Excluding other diseases that cause pancytopenia, such as acute hematopoietic arrest, myelodysplastic syndrome, Fanconi anemia, PNH, Evans syndrome, immune-related pancytopenia, myelofibrosis, hairy cell leukemia, Hypoproliferative leukemia, degenerative T-cell lymphoma, etc.

[0066] Aplastic anemia is divided into chronic aplastic anemia and se...

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Abstract

The invention discloses a traditional Chinese medicine compound for treating blood diseases such as aplastic anemia, myelodysplastic syndrome, thrombocytopenic purpura, leukemia, and the like. The compound comprises the following raw materials: radix codonopsis, radix astragali, dried radix rehmanniae, radix rehmanniae preparata, deerhorn glue, donkey-hide gelatin, Chinese yam, bighead atractylodes rhizome, poria cocos, psoralea corylifolia, sharpleaf galangal fruit, semen cuscutae, ligustrum lucidum, wolfberry, white peony root, fleece-flower root, malt, Chinese angelica, red sage root, peach seed, red peony root, hairyvein agrimony, lotus rhizome node, villous amomum fruit, fried semen ziziphi jujubae, esliptae herba, fructus forsythiae, and cortex moutan. The compound is prepared by following steps: mixing the raw materials mentioned above according to a certain weight ratio, grinding the raw materials, then sieving with a 100-mesh sieve, packaging the powder, and making into powder preparation. The medicine compatibility of the compound is reasonable, the preparation is simple, it has been testified through experiments and clinical tests that the compound has a prominent curative effect and no toxic or side effect, and is an ideal drug for improving the immunity and marrow hematopoietic function.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a compound recipe and a preparation method for treating aplastic anemia, myelodysplastic syndrome, thrombocytopenic purpura, leukemia and other blood diseases made from traditional Chinese medicine and its application. Background technique [0002] Aplastic anemia is a group of syndromes caused by bone marrow hematopoietic failure, mainly manifested as pancytopenia, and clinically seen three syndromes of anemia, bleeding and infection. The "asthenia" and "blood syndrome" described in traditional Chinese medicine are very similar to this disease. Its pathogenesis is complicated, the condition is critical, the course of the disease is lingering and difficult to heal, and the treatment is difficult and difficult to heal. The incidence of this disease has been increasing year by year due to the influence of factors such as the living environment of the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9064A61P7/06A61P7/04A61P7/00A61P35/02A61K35/32A61K35/36
Inventor 杜丽娟杜秉乾
Owner 杜丽娟