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Flexible nano liposome as well as preparation method and application of flexible nano liposome

A nano-liposome and liposome technology, applied in the application of flexible nano-liposome in cosmetics, refers to the field of asiaticoside flexible nano-liposome and its preparation, which can solve the problem of short contact time between asiaticoside and skin , Can not give full play to the effect of asiaticoside and the effect of time, to achieve the effect of good skin absorption, high encapsulation efficiency and drug loading, and good stability

Inactive Publication Date: 2014-01-22
TIANBO MEDICAL TECH SUZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main form of asiaticoside used in cosmetics is the cream formulation. Due to the long repair cycle of the skin, the habit of using the cream formulation will inevitably determine that the contact time of asiaticoside with the skin is short, and the effect of asiaticoside cannot be fully exerted. Action effect and action time

Method used

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  • Flexible nano liposome as well as preparation method and application of flexible nano liposome
  • Flexible nano liposome as well as preparation method and application of flexible nano liposome
  • Flexible nano liposome as well as preparation method and application of flexible nano liposome

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Dissolve 10mg of dipalmitoyl neutral phosphatidylcholine and 1mg of cholesterol in chloroform, dissolve 0.25mg of vitamin E and BHA mixed antioxidants in a small amount of ethanol, and then mix with chloroform solution; dissolve 3mg of asiaticoside, 2mg of cholic acid Sodium, 1.5 mg hyaluronic acid, 40 mg lactose were dissolved in phosphate buffer solution with pH 7.0; the aforementioned phosphate buffer solution was added to chloroform solution, ultrasonically formed homogeneous emulsion, after standing for 30 minutes, the emulsion was placed on a rotary evaporator The organic solvent was removed by rotary evaporation to obtain asiaticoside liposome suspension; the liposome suspension was sonicated for 90 cycles with a probe-type ultrasonic cell disruptor (5 seconds per cycle, 5 seconds in between, ice bath) Finally, use the AVESTIN high-pressure homogenizer to homogenize 3 times, and then pass the 100nm microporous membrane 10 times through the AVESTIN extruder; the li...

Embodiment 2

[0038] Dissolve 100mg of soybean egg neutral phospholipids and 50mg of cholesterol in chloroform by ultrasonication in a water bath, dissolve 0.26mg of vitamin E and BHA mixed antioxidants in a small amount of ethanol, and then mix with chloroform; 35mg of asiaticoside, 15mg of sodium cholate, 1.5 mg of hyaluronic acid and 400 mg of mannitol were dissolved in phosphate buffer at pH 7.0; the aforementioned phosphate buffer and chloroform solution were sonicated in a water bath to form a uniform emulsion, and after standing for 30 minutes, rotary evaporation obtained lipid Body suspension; the liposome suspension was sonicated for 60 cycles with a probe-type ultrasonic cell disruptor (5 seconds per cycle, 5 seconds at rest, ice bath), and then homogenized 3 times with an AVESTIN high-pressure homogenizer , and then pass through a 100nm microporous filter membrane 10 times through the AVESTIN extrusion instrument, and put the extruded liposome suspension into a dialysis bag (molec...

Embodiment 3

[0041] Dissolve 1000mg of soybean egg neutral phospholipids and 50mg of cholesterol in chloroform by ultrasonication in a water bath, dissolve 2.5mg of vitamin E and BHA mixed antioxidants in a small amount of ethanol, and mix with chloroform; 350mg of asiaticoside, 150mg of sodium cholate, 15mg of hyaluronic acid and 4000mg of mannitol were dissolved in phosphate buffer solution of pH 7.0; the aforementioned phosphate buffer solution and chloroform solution were ultrasonically formed into a uniform emulsion in a water bath, and after standing for 30 minutes, rotary evaporation obtained liposomes Suspension; the liposome suspension was sonicated for 90 cycles with a probe-type ultrasonic cell disruptor (5 seconds for each cycle, 5 seconds for an interval, ice bath), and then homogenized 3 times with an AVESTIN high-pressure homogenizer. Then pass through the 100nm microporous filter membrane 10 times through the AVESTIN extruder, and put the extruded liposome suspension into th...

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Abstract

The invention relates to flexible nano liposome as well as a preparation method and application of the flexible nano liposome. The flexible nano liposome consists of the following components in parts by weight: 1-1000 parts of neutral phospholipid, 1-1000 parts of cholesterol, 0.5-500 parts of a surfactant, 0.1-2 parts of hyaluronic acid and 0.5-500 parts of asiaticoside. The asiaticoside flexible nano liposome can obviously promote transdermal absorption and enhance action efficiency of the asiaticoside, and can improve retention and action duration of the asiaticoside on skin surface and deep skin; the asiaticoside flexible nano liposome under a freeze-dried powder state is additionally favorable for use, transportation and storage; and the preparation method of the flexible nano liposome can adopt a mechanical method, and is good in product process and quality stability and is high in repeatability.

Description

technical field [0001] The invention relates to a flexible nano-liposome and a preparation method thereof, in particular to an asiaticoside flexible nano-liposome and a preparation method thereof, and the application of the flexible nano-liposome in cosmetics. Background technique [0002] Asiaticoside is the extract of dried whole grass or rooted whole grass of Umbelliferae Centella asiatica (L.) Urban, which can tighten the connection between the epidermis and the dermis, soften the skin, and help to resolve The phenomenon of skin relaxation makes the skin smooth and elastic; helps to promote the formation of collagen in the dermis, regenerates fibrin, and reconnects, fundamentally eliminates mother's lines, and makes the skin firm and smooth. It also helps damaged tissue heal and firm the skin. As a traditional medicine, it has been used for a long time in Asia, Africa and other places, mainly for the treatment of diseases of the skin and mucous membranes. Due to its go...

Claims

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Application Information

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IPC IPC(8): A61K8/14A61K8/73A61K8/60A61Q19/00
Inventor 江妍
Owner TIANBO MEDICAL TECH SUZHOU
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