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A method for synergistically extracting total flavonoids from Scutellaria baicalensis with graphene oxide and ethanol

A technology of total flavonoids and graphene of Scutellaria baicalensis, applied in chemical instruments and methods, inorganic chemistry, organic chemistry and other directions, can solve the problems of complex production process, high extraction temperature, low extraction rate and the like, achieve less dosage and improve yield , the effect of accelerating the leaching rate

Active Publication Date: 2015-08-19
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The present invention aims at providing a graphene oxide-ethanol synergistic method for extracting total flavonoids of Scutellaria baicalensis in view of the shortcomings of existing extraction methods such as high extraction temperature, low extraction rate and complicated production process for total flavonoids of Scutellaria baicalensis and baicalein. The total flavonoids and baicalein are efficient and simple, and the total flavonoids and baicalein of Scutellaria baicalensis have a high yield

Method used

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  • A method for synergistically extracting total flavonoids from Scutellaria baicalensis with graphene oxide and ethanol
  • A method for synergistically extracting total flavonoids from Scutellaria baicalensis with graphene oxide and ethanol
  • A method for synergistically extracting total flavonoids from Scutellaria baicalensis with graphene oxide and ethanol

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Experimental program
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Effect test

Embodiment 1

[0025] Wash 10g of Scutellaria baicalensis to remove impurities, dry and pulverize it and pass through a 10-20 mesh sieve to obtain scutellaria baicalensis powder; add the scutellaria baicalensis powder and 0.003g of graphene oxide into an aqueous ethanol solution with a volume concentration of 50% for reflux extraction, and the extraction temperature The temperature is 50°C, the extraction time is 6 hours, the mass volume ratio of the scutellaria baicalensis powder and the ethanol aqueous solution is 1g:15mL; after the extraction is completed, it is cooled to room temperature, the filtrate is concentrated under reduced pressure after filtration, and the solvent is recovered to obtain the total baicalensis baicalensis. Flavonoids extract: dry the obtained Scutellaria baicalensis total flavones extract and carry out various analysis tests, and carry out single ethanol solution reflux extraction under the same conditions at the same time as a comparison, the HPLC diagram is as fol...

Embodiment 2

[0028] Wash 10g of Scutellaria baicalensis medicinal material to remove impurities, dry and pulverize it and pass through a 10-20 mesh sieve to obtain scutellaria baicalensis powder; add the scutellaria baicalensis powder and 0.011g of graphene oxide into an aqueous ethanol solution with a volume concentration of 60% for reflux extraction, and the extraction temperature The temperature is 70°C, the extraction time is 6 hours, the mass volume ratio of the scutellaria baicalensis powder and the ethanol aqueous solution is 1g:15mL; after the extraction is completed, it is cooled to room temperature, the filtrate is concentrated under reduced pressure after filtration, and the solvent is recovered to obtain the total baicalensis baicalensis. Flavonoids extract: After drying the total flavonoids extract of Scutellaria baicalensis, various analysis tests were carried out. At the same time, a single ethanol solution reflux extraction under the same conditions was carried out as a comp...

Embodiment 3

[0033] Wash 10g of Scutellaria baicalensis to remove impurities, dry and pulverize it and pass through a 10-20 mesh sieve to obtain scutellaria baicalensis powder; add the scutellaria baicalensis powder and 0.02g of graphene oxide into an aqueous ethanol solution with a volume concentration of 70% for reflux extraction, and the extraction temperature The temperature is 60°C, the extraction time is 6 hours, the mass volume ratio of the scutellaria baicalensis powder and the ethanol aqueous solution is 1g:20mL; after the extraction is completed, it is cooled to room temperature, the filtrate is concentrated under reduced pressure after filtration, and the solvent is recovered to obtain total baicalensis baicalensis. Flavonoids extract: After drying the total flavonoids extract of Scutellaria baicalensis, various analysis tests were carried out. At the same time, a single ethanol solution reflux extraction under the same conditions was carried out as a comparison.

[0034] Accord...

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Abstract

The invention discloses a method for extracting scutellaria baiculensis total flavonoid by graphene oxide-ethanol synergy, which is a method for extracting total flavonoid from scutellaria baiculensis drugs by using grapheme oxide serving as a catalyst and synergized with ethanol water solution. When scutellaria baiculensis total flavonoid is extracted by adopting the method, the yield of scutellaria baiculensis total flavonoid in the product is 20-25 percent, the content is 40-70 percent, wherein the yield of baicalein is 7-14 percent, and the content is 10-20 percent, so that the content of baicalein in the product is greatly increased while the yield of total flavonoid and content are increased. According to the method, the extraction rate of the total flavonoid can be 96 percent in primary extraction by the method, the drug is not needed to be extracted for multiple times, and the process is simple. Furthermore, the graphene oxide is adopted as a catalyst, the extraction process is green and environment-friendly, other separations are not needed after extraction, and the problems of high extraction temperature, low extraction rate, equipment corrosion, wastewater pollution and high production cost in the catalytic extraction process by using inorganic acid can be solved.

Description

1. Technical field [0001] The invention relates to a method for extracting active ingredients in medicinal plants, in particular to a method for synergistically extracting total flavonoids from Scutellaria baicalensis with graphene oxide and ethanol. 2. Background technology [0002] Scutellaria baicalensis is a commonly used Chinese herbal medicine. It is a medicinal material recorded in the Pharmacopoeia of the People's Republic of China. The main medicinal components of Scutellaria baicalensis are flavonoids such as baicalin, wogonin, baicalein and wogonin. Among them, baicalin, wogonin and other baicalin compounds have antibacterial, anti-inflammatory, antipyretic and analgesic properties. The biological activity is much stronger than that of baicalin compounds, and in the human body, baicalin must be hydrolyzed into baicalin compounds to be absorbed by the human body. Therefore, baicalein is the most clinically used baicalin flavonoid compound. However, the content of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/30C01B31/00A61K36/539C01B32/198
Inventor 魏凤玉王欣
Owner HEFEI UNIV OF TECH
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