The invention relates to novel rhizoma polygonati wine and a production process thereof. The production process comprises the following steps: performing enzymolysis on traditional Chinese medicinal materials, performing diastatic fermentation, performing base liquor fermentation, adding edible alcohol for soaking, filtering, separating and the like. The wine provided by the invention takes the pure traditional Chinese medicinal materials with homology of medicine and food as raw materials and is safe and harmless to the human body; the wine meets the compatibility of the traditional Chinese medicinal materials, and has the effects of strengthening the spleen and stomach, reinforcing liver and kidney, nourishing yin and blood, regulating deficiency, calming the heart and tranquilizing themind and the like; by virtue of steps of filtration, beta-cyclodextrin debitterization and the like, bitterness is removed, and the taste is optimized. The innovation point is that by utilizing a manner of directly fermenting after performing enzymolysis on the traditional Chinese medicinal materials, the active ingredients in the medicinal materials are efficiently and fully released. Compared with the traditional health medicinal liquor, the novel rhizoma polygonati wine disclosed by the invention has the advantages that the production cycle is greatly shortened, the ingredients of the traditional Chinese medicinal materials are fully utilized, and the losses of nutritional ingredients are greatly reduced.