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Preparation method of panax notoginseng total saponin and hydroxylapatite bionic compound

A technology of total saponins hydroxyapatite and Panax notoginseng total saponins, applied in the field of medical devices, can solve the problems of unsatisfactory results, poor load-bearing capacity, slow biodegradation, etc., and achieves remarkable osteogenic effect, good osteogenic effect, Good osteoinductive effect

Inactive Publication Date: 2014-01-29
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although autologous bone grafting is the gold standard for repairing bone defects, donor site complications are its fatal flaws that are difficult to overcome
Most of the osteogenic materials used clinically today come from foreign countries, which are costly and have unsatisfactory results. They have poor mechanical strength, slow biodegradation, and poor load-bearing capacity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: The preparation steps of this embodiment are as follows:

[0020] a. Take a certain amount of calcium nitrate crystal Ca (NO 3 ) 2 4H 2 O and diamine hydrogen phosphate (NH4) 2 HPO 4 , Dissolve in a certain amount of deionized water according to the molar ratio of calcium to phosphorus of 1.5:1, and then add ammonia water while maintaining stirring (stirring speed 100r / min), adjust the pH of the system, and keep the pH value of the solution at 6.8. The temperature of the system rises rapidly to 60°C;

[0021] b. Take a certain amount of Chinese medicine extract Panax notoginseng saponins, dissolve it in a certain amount of deionized water, stir under vacuum conditions, and keep the temperature at 60 ° C; the sum of the calcium nitrate crystals and diamine hydrogen phosphate The mass ratio of seven total saponins is 0.5:1;

[0022] c. Mix the solution obtained in step a and the solution obtained in step b under vacuum conditions. The magnetic stirrer...

Embodiment 2

[0024] Embodiment 2: The preparation steps of this embodiment are as follows:

[0025] a. Take a certain amount of calcium nitrate crystal Ca (NO 3 ) 2 4H 2 O and diamine hydrogen phosphate (NH4) 2 HPO 4 Dissolve in a certain amount of deionized water according to the calcium-phosphorus molar ratio of 2:1, and then add ammonia water while maintaining stirring (stirring speed 280r / min), adjust the pH of the system, and keep the pH value of the solution at 7.2. The temperature of the system rose rapidly to 75°C;

[0026] b. Take a certain amount of Chinese medicine extract Panax notoginseng saponins, dissolve it in a certain amount of deionized water, stir under vacuum conditions, and keep the temperature at 75°C; the sum of the calcium nitrate crystals and diamine hydrogen phosphate The mass ratio of seven total saponins is 1.5:1;

[0027] c. Mix the solution obtained in step a and the solution obtained in step b under vacuum conditions. The magnetic stirrer maintains a s...

Embodiment 3

[0029] Embodiment 3: The preparation steps of this embodiment are as follows:

[0030] a. Take a certain amount of calcium nitrate crystal Ca (NO 3 ) 2 4H 2 O and diamine hydrogen phosphate (NH4) 2 HPO 4 , dissolve in a certain amount of deionized water according to the calcium-phosphorus molar ratio of 5:3, and then add ammonia water while maintaining stirring (stirring speed 200r / min) to adjust the pH of the system and keep the pH value of the solution at 7.0. The temperature of the system rose rapidly to 65°C;

[0031] b. Take a certain amount of Chinese medicine extract Panax notoginseng saponins, dissolve it in a certain amount of deionized water, stir under vacuum conditions, and keep the temperature at 65°C; the sum of the mass of the calcium nitrate crystals and diamine hydrogen phosphate The mass ratio of seven total saponins is 1:1;

[0032] c. Mix the solution obtained in step a and the solution obtained in step b under vacuum conditions, maintain a stirring s...

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Abstract

The invention relates to a preparation method of a panax notoginseng total saponin and hydroxylapatite bionic compound and aims to provide the preparation method of the panax notoginseng total saponin and hydroxylapatite bionic compound. The technical scheme is as follows: the preparation method comprises the steps: a, dissolving a calcium nitrate crystal and diammonium hydrogen phosphate into a certain quantity of deionized water according to the calcium-to-phosphorus mole ratio of (1.5-2):1, stirring, regulating the pH value to 6.8-7.2, and heating to 60-75 DEG C; b, dissolving panax notoginseng total saponins into a certain quantity of deionized water, stirring under a vacuum condition, and keeping the temperature at 60-75 DEG C; c, mixing the solutions obtained in the steps a and b under a vacuum condition, stirring, maintaining the system temperature at 60-75 DEG C to react, carrying out ultrasonic dispersion for 30-50min, introducing nitrogen to remove oxygen, and cooling after the stirring and reaction are ended; d, carrying out vacuum suction on the mixed solution obtained in the step c, and then, drying to obtain the panax notoginseng total saponin and hydroxylapatite bionic compound.

Description

technical field [0001] The invention relates to a preparation method of a Panax notoginseng saponin hydroxyapatite biomimetic compound, which can be made into a hydroxyapatite biomimetic material widely used in plastic surgery, trauma orthopedics and oral implant restoration and reconstruction surgery. It belongs to the technical field of medical equipment. Background technique [0002] Bone nonunion and delayed union caused by bone defect are difficult problems in clinical treatment. Although autologous bone grafting is the gold standard for repairing bone defects, donor site complications are fatal defects that are difficult to overcome. Most of the osteogenic materials currently used clinically come from abroad, which are costly and have unsatisfactory results. They have poor mechanical strength, slow biodegradation, and poor load-bearing capacity. The ideal tissue engineered bone should have: (1) good biocompatibility and biodegradable absorbability; (2) suitable three...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/56A61L27/12
Inventor 陈建治柳毅林振吕惠卿张乐其
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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