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Milk oligosaccharide-galactooligosaccharide composition for infant formula containing the soluble oligosaccharide fraction present in milk, and having a low level of monosaccharides, and a process to produce the composition

A galactooligosaccharide, soluble technology, applied in the field of infant formula products, producing the oligosaccharide mixture, to achieve good physical stability

Inactive Publication Date: 2014-01-29
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, such mixtures only provide an approximation of the oligosaccharide mixture present in human milk

Method used

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  • Milk oligosaccharide-galactooligosaccharide composition for infant formula containing the soluble oligosaccharide fraction present in milk, and having a low level of monosaccharides, and a process to produce the composition
  • Milk oligosaccharide-galactooligosaccharide composition for infant formula containing the soluble oligosaccharide fraction present in milk, and having a low level of monosaccharides, and a process to produce the composition
  • Milk oligosaccharide-galactooligosaccharide composition for infant formula containing the soluble oligosaccharide fraction present in milk, and having a low level of monosaccharides, and a process to produce the composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0150] The method for preparing the CMOS-GOS mixture of the present invention:

[0151] 207,000 kg whey ultrafiltration permeate was pre-concentrated to 29% (w / w) total solids (TS), pasteurized at about 75°C for about 30 seconds, then concentrated by evaporation at 60°C to reach 58% (w / w) ) of TS. The liquid was divided into 3 crystallizers and each crystallizer was cooled at a rate of 2°C / hour for 24 hours to crystallize the lactose. The crystallized lactose is washed and then removed using a water squeezer. The remaining liquid was clarified with a decanter.

[0152] 114,000 kg of 23% TS material obtained from the clarifier was desalted in a manner known per se through a combination of a weak cation column and a mixed bed column to obtain 109,000 kg of 90% desalted liquid of 14.4% TS.

[0153]5,400 kg of the desalted oligosaccharide mixture was concentrated to 52% TS by evaporation. It was then heated to 60°C in a standard tank at a pH of 5.5 to 6.5. Determine the conce...

Embodiment 2

[0160] This example shows the evaluation of total solids oligosaccharides, monosaccharides, ash, lactic acid and citric acid during the process of Example 1 of the invention. CMOS corresponds to the mixture before hydrolysis step d), CMOS-GOS corresponds to the mixture after hydrolysis step d), Nano CMOS-GOS corresponds to the mixture after nanofiltration step f). These samples are also used to generate figure 1 HPLC profiles (1), (2) and (3) in and data in Table 1.

[0161]

Embodiment 3

[0163] Decreased Maillard Reactivity After Nanofiltration:

[0164] The infant formulas in Table 2 below were formulated and tested for Maillard activity. In the table, MSW means modified sweet whey, which is a sweet whey from which casein glycomacropeptide (CGMP) has been removed. Infant formulas comprising the CMOS-GOS mixture of the invention, added in the form of a liquid concentrate or as a dry powder, were compared to those comprising non-nanofiltered CMOS and commercially available GOS ( GOS) infant formula was tested against. Standard reaction conditions were used to test Maillard reactivity. The result is as image 3 shown. The oligosaccharide mixtures of the present invention, whether added to infant formula in liquid or powder form, lead to a significant reduction in Maillard reactivity in the final spray-dried product.

[0165] Table 2

[0166]

[0167] 1 long chain polyunsaturated fatty acids

[0168] 2 Example 1

[0169] GOS by FrieslandCampina (N...

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Abstract

The invention discloses an oligosaccharide mixture derived from cow's milk that can be easily spray dried comprising (a) a soluble oligosaccharide population which is the same as that of soluble oligosaccharides found in cow's milk and (b) ²-galactooligosaccharides formed by the action of ²-galacotsidase on lactose and the milk oligosaccharides. The mixture having a total monosaccharide content of less than 5% w / v and a lactose:oligosaccharide ratio of less than 20. A process for obtaining such a mixture, which includes a nanofiltration step, is disclosed. Nutritional compositions, especially infant formula, comprising said oligosaccharide mixture are also disclosed.

Description

field of invention [0001] The present invention relates to oligosaccharide mixtures obtained from bovine milk and food products, in particular infant formulas, comprising said oligosaccharide (OS) mixtures, and to methods for producing said oligosaccharide mixtures. Background of the invention [0002] The human colon is populated by a variety of bacteria that have both positive and negative effects on gut physiology, as well as other systemic effects. Predominant groups of bacteria found in the colon include Bacteroides species, especially Bifidobacteria, Eubacteria, Clostridia and Lactobacilli. These bacteria have variable activity in response to substrate availability, redox potential, pH, O2 tension and their distribution in the colon. In general, bacteria in the gut can be classified into species that exert potentially harmful or beneficial effects on their hosts. Pathogenic effects (which may be caused by, for example, Clostridium or Bacteroides) include diarrhea, in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A23L1/308A61K31/702A23L33/00
CPCA23V2002/00A23L1/308A23L1/296A23C2210/206C12Y302/01032C12Y302/01023A23L33/21A23L33/40A23V2200/32A23V2200/304A23V2200/3202A23L33/135A23L33/00C12P19/04C12P19/14
Inventor R·贝罗卡尔M·布劳恩A·塞瓦略斯V·玛丽G·里卡德
Owner NESTEC SA
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