The invention discloses a nano CMOS (Complementary Metal-Oxide-Semiconductor) integrated device with a strain Si vertical clip-shaped channel and a preparation method of the device. The preparation method comprises the steps of firstly, preparing an active region on a substrate for isolation at 600 DEG C-800 DEG C, respectively and continuously growing a Si buffer layer, a gradual-change SiGe layer, a fixed component SiGe layer, a strain Si layer, a Si buffer layer, a gradual change SiGe layer, strain Si, fixed component SiGe layer, a light-doped source drain layer, a strain Si layer, a light-doped source drain (LDD) layer and a fixed component SiGe layer on an NMOS (N-channel Metal Oxide Semiconductor) active region and a PMOS (P-channel Metal Oxide Semiconductor) active region; respectively conducting dry etching on a drain channel and a grate channel on the PMOS active region, preparing drain regions and grate electrodes in the channels to form an NMOS device; and conducting photoetching on a lead wire to form a drain metal lead wire, a source metal lead wire and a grate metal lead wire so as to manufacture the CMOS integrated device and a circuit. According to the nano CMOS integrated device and the preparation method, the characteristic of anisotropism of the mobility rate of tensile strain Si material is utilized, the CMOS integrated device with the strain Si clip-shaped vertical channel and a circuit are manufactured under low temperature by the technology of the combination of a vertical structure and a horizontal structure, wherein the performance of the CMOS integrated device with the strain Si clip-shaped vertical channel is enhanced.