Liquorice particles and preparation method thereof

A technology of licorice and granules, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as high sugar content, long production cycle, and lack of effective ingredients, and achieve The content of active ingredients is high, it is not easy to absorb moisture and get wet, and the effect of long storage time

Active Publication Date: 2014-02-12
LUOYANG HUIZHONG ANIMAL MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, using this method to prepare licorice granules has low extraction efficiency, insufficient extraction of active ingredients, long production cycle, high sugar content, easy moisture absorption and caking, and high requirements for packaging materials and storage conditions.
The patent of CN 102319283A discloses a method of heating reflux to prepare licorice granules for veterinary use, but its active ingredients do not meet the standards disclosed in the Veterinary Pharmacopoeia of the People's Republic of China (2010 Edition Part II), and are not suitable for practical application

Method used

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  • Liquorice particles and preparation method thereof
  • Liquorice particles and preparation method thereof
  • Liquorice particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1, Preparation Example 1 of Licorice Granules

[0025] Add 10 kg of licorice into the hot reflux low-temperature extraction pot, add 55% ethanol solution 12 times, soak for 30 minutes to make the medicinal materials soak. Pass in hot steam, control the pressure in the tank to 40-50Kpa, and perform low-temperature extraction at a temperature of 65°C. Extract 8 times, 20min each time, and concentrate while extracting until the extract is basically colorless and the extraction is complete. Pump out all the extracts to a concentration tank, and control the temperature at 60°C to concentrate to a clear cream with a specific gravity of 1.10. Add 0.5% (v / v) chitosan clarifier to the concentrated solution, stir well, stand for 12h, filter, and take the supernatant. The supernatant was concentrated under reduced pressure to a thick paste with a relative density of 1.25, 500 g of polyvinylpyrrolidone, 500 g of hydroxypropyl cellulose, and 1000 g of maltodextrin were added a...

Embodiment 2

[0026] Example 2: Preparation Example 2 of Licorice Granules

[0027] Add 10 kg of licorice to the hot reflux low temperature extraction pot, add 50% ethanol solution 15 times, soak for 30 minutes to make the medicinal materials soak. Pass in hot steam, control the pressure in the tank to 40-50Kpa, and perform low-temperature extraction at a temperature of 70°C. Extract 6 times, 30 minutes each time, and concentrate while extracting until the extract is basically colorless and the extraction is complete. Pump out all the extracts to a concentration tank, and control the temperature at 65°C to concentrate to a clear cream with a specific gravity of 1.10. Add 1% (v / v) chitosan clarifier to the concentrated solution, stir evenly, stand for 12h, filter, and take the supernatant. The supernatant was concentrated under reduced pressure to a thick paste with a density of 1.25, and 600 g of polyvinylpyrrolidone, 600 g of hydroxypropyl cellulose, and 1200 g of maltodextrin were added and...

Embodiment 3

[0028] Example 3 Preparation Example 3 of Licorice Granules

[0029] Add 10 kg of licorice to the hot reflux low-temperature extraction pot, add a 60% ethanol solution 14 times, soak for 30 minutes to make the medicinal materials soak. Pass in hot steam, control the pressure in the tank to 40-50Kpa, and perform low-temperature extraction at a temperature of 60°C. Extract 6 times, 30 minutes each time, and concentrate while extracting until the extract is basically colorless and the extraction is complete. Pump out all the extracts to a concentration tank, and control the temperature at 70°C to concentrate to a clear cream with a specific gravity of 1.10. Add 1% chitosan clarifier to the concentrated solution, stir evenly, let stand for 12h, filter, and take the supernatant. The supernatant was concentrated under reduced pressure to a thick paste with a density of 1.3, and 600 g of polyvinylpyrrolidone, 650 g of hydroxypropyl cellulose, and 1500 g of maltodextrin were added, and ...

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Abstract

The invention discloses veterinary liquorice particles, which are more convenient to store and transport. The veterinary liquorice particles are prepared from the following components in parts by weight: 170-200 parts of liquorice extractum (containing 1000 parts of crude drugs), 50-80 parts of polyvinylpyrrolidone, 50-80 parts of hydroxy propyl cellulose and 100-150 parts of maltodextrin. Cane sugar is added to the components to reach 1000 parts. The preparation method of the liquorice particles comprises the following steps: carrying out low-temperature reflux extraction on the liquorice crude drugs, and adding the polyvinylpyrrolidone, the hydroxy propyl cellulose, the cane sugar and the like; and pelletizing and drying, so as to obtain the liquorice particles, which are high in effective ingredients, stable in ingredients, not easy to absorb moisture, good in stability and long in storage time.

Description

Technical field [0001] The invention relates to licorice granules and a preparation method thereof, and belongs to the field of traditional Chinese medicine. Background technique [0002] Licorice preparation refers to a traditional Chinese medicine preparation prepared by extracting active ingredients from the roots and rhizomes of legume perennial herb licorice plus medicinal auxiliary materials. Licorice preparations have antiviral, anti-inflammatory, detoxifying, and immune enhancement effects, and have a wide range of effects in the treatment of respiratory and gastrointestinal diseases. In veterinary clinics, licorice preparations are mainly used for asthma and coughing, sore throat, etc. caused by various causes. [0003] The chemical composition of licorice is extremely complex, containing a variety of chemical components, the main components are glycyrrhizic acid, glycyrrhizin and so on. The compounds isolated from licorice so far are glycyrrhizin, glycyrrhetinic acid, g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61K9/16A61K47/38A61P1/00A61P11/00A61P11/04A61P29/00A61P31/12A61P37/04
Inventor 张许科刘兴金张晓会
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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