Artemisinin and preparation method thereof

A technology of artemisinin and Artemisia annua, applied in the direction of organic chemistry, can solve the problems of not meeting the requirements of artemisinin production, difficult release of artemisinin solution, low yield of silica gel column chromatography, etc., and achieve market application The effect of broad prospects, improved extraction rate, and shortened extraction time

Inactive Publication Date: 2014-03-26
JISHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Artemisinin is a colorless needle-like crystal with a bitter taste, and is easily soluble in acetone, ethyl acetate, chloroform, benzene, petroleum ether and other weakly polar organic solvents, so artemisinin is generally extracted from Artemisia annua. These organic solvents are used as extractants, but the main components of Artemisia annua are highly polar and hydrophilic substances such as cellulose and pectin, and these solvents have poor penetration to strong polar and hydrophilic substances. Artemisinin is wrapped by plant cell tissue with cellulose and pectin as the main components, so these solvents have great mass transfer resistance during the extraction process, and it is di

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0015] Example 1:

[0016] (1) Processing of raw materials: Dry and crush the raw materials of Artemisia annua to 25 mesh.

[0017] (2) The extraction of artemisinin: the material was refluxed and extracted twice with ethyl acetate as the solvent. The volume-to-mass ratio of the solvent to the material was 3:1, and the extraction time was 4.5 hours. The two extracts were combined and concentrated. For standby, the unit of volume in the volume-to-mass ratio is milliliter and the unit of mass is gram. During the extraction process, the extraction tank is intermittently evacuated and broken, and the vacuum pulse is used to enhance the mass transfer.

[0018] (3) Purification of artemisinin: The concentrated artemisinin extract is adsorbed with medium-polarity macroporous adsorption resin, and then 91% ethanol is used for elution. The eluate is concentrated, crystallized and 60% ethanol After recrystallization and drying, the artemisinin product is obtained, and the mass fraction of art...

Example Embodiment

[0020] Example 2:

[0021] (1) Treatment of raw materials: Dry and crush the raw materials of Artemisia annua to 40 mesh.

[0022] (2) Extraction of artemisinin: reflux the material twice with ethyl acetate as the solvent. The volume-to-mass ratio of solvent to material during extraction is 6:1, and the extraction time is 3 hours. The two extracts are combined and concentrated. For standby, the unit of volume in the volume-to-mass ratio is milliliter and the unit of mass is gram. During the extraction process, the extraction tank is intermittently evacuated and broken, and the vacuum pulse is used to enhance the mass transfer.

[0023] (3) Purification of artemisinin: The concentrated artemisinin extract is adsorbed with a medium-polarity macroporous adsorption resin, and then 95% ethanol is used for elution. The eluate is concentrated, crystallized and 75% ethanol After recrystallization and drying, the artemisinin product is obtained, and the mass fraction of artemisinin in the pr...

Example Embodiment

[0025] Example 3:

[0026] (1) Treatment of raw materials: Dry and crush the raw materials of Artemisia annua to 70 mesh.

[0027] (2) Artemisinin extraction: reflux the material twice with ethyl acetate as the solvent. The volume-to-mass ratio of the solvent to the material during extraction is 10:1, and the extraction time is 1.5 hours. The two extracts are combined and concentrated. For standby, the unit of volume in the volume-to-mass ratio is milliliter and the unit of mass is gram. During the extraction process, the extraction tank is intermittently evacuated and broken, and the vacuum pulse is used to enhance the mass transfer.

[0028] (3) Purification of artemisinin: the concentrated artemisinin extract is adsorbed with medium-polarity macroporous adsorption resin, and then eluted with 99% ethanol, and the eluate is concentrated, crystallized and 88% ethanol After recrystallization and drying, the artemisinin product is obtained, and the mass fraction of artemisinin in the ...

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Abstract

The invention discloses a preparation method for artemisinin. The method comprises the following steps: (1) drying and smashing artemisia apiacea as a medical raw material into powder of 20-80 meshes; (2) performing reflux extraction twice on the material, combing extracting solutions generated from the two reflux extractions and concentrating for standby, wherein ethyl acetate is used as a solvent, and intermittent vacuumizing and vacuum breaking are performed on an extracting tank during extracting process; (3) adsorbing a concentrated artemisinin extracting solution by using macroporous resin with moderate polarity, eluting the concentrated artemisinin extracting solution by using 90-99.7% of alcohol, concentrating and crystallizing an eluate, recrystallizing with 50-90% of alcohol, and drying to obtain an artemisinin product. According to the invention, through the combination between pulsating vacuum extraction and adsorption of macroporous resin, the production with low cost and high efficiency for preparing the artemisinin from the artemisia apiacea is realized and the market application prospect is wide.

Description

technical field [0001] The invention relates to a preparation method of artemisinin, in particular to a method for extracting and purifying artemisinin from Chinese medicinal material Artemisia annua. Background technique [0002] Artemisinin is a new sesquiterpene lactone antimalarial drug with peroxy groups extracted from the traditional Chinese medicine Artemisia annua, on the basis of which a variety of derivatives have been synthesized, such as dihydroartemisinin, artemether, artemisia annua Artemisinin drugs have very important medicinal value due to their low toxicity and strong anti-masochistic properties. [0003] Artemisinin is a colorless needle-like crystal with a bitter taste, and is easily soluble in acetone, ethyl acetate, chloroform, benzene, petroleum ether and other weakly polar organic solvents, so artemisinin is generally extracted from Artemisia annua. These organic solvents are used as extractants, but the main components of Artemisia annua are highly ...

Claims

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Application Information

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IPC IPC(8): C07D493/20
CPCC07D493/20
Inventor 田宏现
Owner JISHOU UNIVERSITY
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